171 related articles for article (PubMed ID: 19394219)
21. Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.
Lachance N; Guiral S; Huang Z; Leclerc JP; Li CS; Oballa RM; Ramtohul YK; Wang H; Wu J; Zhang L
Bioorg Med Chem Lett; 2012 Jan; 22(1):623-7. PubMed ID: 22101133
[TBL] [Abstract][Full Text] [Related]
22. Effect of troglitazone on the desaturases in a rat model of insulin-resistance induced by a sucrose-rich diet.
Montanaro MA; Lombardo YB; González MS; Bernasconi AM; Chicco A; Rimoldi OJ; Basabe JC; Brenner RR
Prostaglandins Leukot Essent Fatty Acids; 2005 Apr; 72(4):241-50. PubMed ID: 15763435
[TBL] [Abstract][Full Text] [Related]
23. Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Uto Y; Ueno Y; Kiyotsuka Y; Miyazawa Y; Kurata H; Ogata T; Yamada M; Deguchi T; Konishi M; Takagi T; Wakimoto S; Ohsumi J
Eur J Med Chem; 2010 Nov; 45(11):4788-96. PubMed ID: 20801551
[TBL] [Abstract][Full Text] [Related]
24. Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.
Zhao H; Serby MD; Smith HT; Cao N; Suhar TS; Surowy TK; Camp HS; Collins CA; Sham HL; Liu G
Bioorg Med Chem Lett; 2007 Jun; 17(12):3388-91. PubMed ID: 17434733
[TBL] [Abstract][Full Text] [Related]
25. 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.
Powell DA; Ramtohul Y; Lebrun ME; Oballa R; Bhat S; Falgueyret JP; Guiral S; Huang Z; Skorey K; Tawa P; Zhang L
Bioorg Med Chem Lett; 2010 Nov; 20(22):6366-9. PubMed ID: 20933412
[TBL] [Abstract][Full Text] [Related]
26. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Tao ZF; Hasvold LA; Leverson JD; Han EK; Guan R; Johnson EF; Stoll VS; Stewart KD; Stamper G; Soni N; Bouska JJ; Luo Y; Sowin TJ; Lin NH; Giranda VS; Rosenberg SH; Penning TD
J Med Chem; 2009 Nov; 52(21):6621-36. PubMed ID: 19842661
[TBL] [Abstract][Full Text] [Related]
27. Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity.
Dillon R; Greig MJ; Bhat BG
Anal Chim Acta; 2008 Oct; 627(1):99-104. PubMed ID: 18790132
[TBL] [Abstract][Full Text] [Related]
28. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
Obukowicz MG; Welsch DJ; Salsgiver WJ; Martin-Berger CL; Chinn KS; Duffin KL; Raz A; Needleman P
J Pharmacol Exp Ther; 1998 Oct; 287(1):157-66. PubMed ID: 9765335
[TBL] [Abstract][Full Text] [Related]
29. Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase.
Dobrzyn P; Dobrzyn A
Expert Opin Ther Pat; 2010 Jun; 20(6):849-53. PubMed ID: 20205608
[TBL] [Abstract][Full Text] [Related]
30. Role of hepatic desaturases in obesity-related metabolic disorders.
Bjermo H; Risérus U
Curr Opin Clin Nutr Metab Care; 2010 Nov; 13(6):703-8. PubMed ID: 20823776
[TBL] [Abstract][Full Text] [Related]
31. Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.
Zhang Z; Sun S; Kodumuru V; Hou D; Liu S; Chakka N; Sviridov S; Chowdhury S; McLaren DG; Ratkay LG; Khakh K; Cheng X; Gschwend HW; Kamboj R; Fu J; Winther MD
J Med Chem; 2013 Jan; 56(2):568-83. PubMed ID: 23245208
[TBL] [Abstract][Full Text] [Related]
32. Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men.
Petersson H; Basu S; Cederholm T; Risérus U
Br J Nutr; 2008 Jun; 99(6):1186-9. PubMed ID: 18062827
[TBL] [Abstract][Full Text] [Related]
33. 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Yang SM; Tang Y; Zhang R; Lu H; Kuo GH; Gaul MD; Li Y; Ho G; Conway JG; Liang Y; Lenhard JM; Demarest KT; Murray WV
Bioorg Med Chem Lett; 2013 Dec; 23(24):6773-6. PubMed ID: 24153205
[TBL] [Abstract][Full Text] [Related]
34. Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Deng Y; Yang Z; Shipps GW; Lo SM; West R; Hwa J; Zheng S; Farley C; Lachowicz J; van Heek M; Bass AS; Sinha DP; Mahon CR; Cartwright ME
Bioorg Med Chem Lett; 2013 Feb; 23(3):791-6. PubMed ID: 23265904
[TBL] [Abstract][Full Text] [Related]
35. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
Liu G; Lynch JK; Freeman J; Liu B; Xin Z; Zhao H; Serby MD; Kym PR; Suhar TS; Smith HT; Cao N; Yang R; Janis RS; Krauser JA; Cepa SP; Beno DW; Sham HL; Collins CA; Surowy TK; Camp HS
J Med Chem; 2007 Jun; 50(13):3086-100. PubMed ID: 17530838
[TBL] [Abstract][Full Text] [Related]
36. Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.
Ramtohul YK; Powell D; Leclerc JP; Leger S; Oballa R; Black C; Isabel E; Li CS; Crane S; Robichaud J; Guay J; Guiral S; Zhang L; Huang Z
Bioorg Med Chem Lett; 2011 Oct; 21(19):5692-6. PubMed ID: 21871798
[TBL] [Abstract][Full Text] [Related]
37. Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.
Sun S; Zhang Z; Raina V; Pokrovskaia N; Hou D; Namdari R; Khakh K; Ratkay LG; McLaren DG; Mork M; Fu J; Ferreira S; Hubbard B; Winther MD; Dales N
Bioorg Med Chem Lett; 2014 Jan; 24(2):526-31. PubMed ID: 24370012
[TBL] [Abstract][Full Text] [Related]
38. Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.
Imamura K; Tomita N; Kawakita Y; Ito Y; Ono K; Nii N; Miyazaki T; Yonemori K; Tawada M; Sumi H; Satoh Y; Yamamoto Y; Miyahisa I; Sasaki M; Satomi Y; Hirayama M; Nishigaki R; Maezaki H
Bioorg Med Chem; 2017 Jul; 25(14):3768-3779. PubMed ID: 28571972
[TBL] [Abstract][Full Text] [Related]
39. Azacycloalkane derivatives as inhibitors of delta-9 stearoyl-coenzyme A desaturase.
Liu G
Expert Opin Ther Pat; 2009 Jun; 19(6):885-91. PubMed ID: 19473107
[TBL] [Abstract][Full Text] [Related]
40. Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.
Iida T; Ubukata M; Mitani I; Nakagawa Y; Maeda K; Imai H; Ogoshi Y; Hotta T; Sakata S; Sano R; Morinaga H; Negoro T; Oshida S; Tanaka M; Inaba T
Eur J Med Chem; 2018 Oct; 158():832-852. PubMed ID: 30248655
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
