BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

266 related articles for article (PubMed ID: 19397324)

  • 1. Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
    Sunami S; Nishimura T; Nishimura I; Ito S; Arakawa H; Ohkubo M
    J Med Chem; 2009 May; 52(10):3225-37. PubMed ID: 19397324
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Basnet A; Thapa P; Karki R; Na Y; Jahng Y; Jeong BS; Jeong TC; Lee CS; Lee ES
    Bioorg Med Chem; 2007 Jul; 15(13):4351-9. PubMed ID: 17493824
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities.
    Son JK; Zhao LX; Basnet A; Thapa P; Karki R; Na Y; Jahng Y; Jeong TC; Jeong BS; Lee CS; Lee ES
    Eur J Med Chem; 2008 Apr; 43(4):675-82. PubMed ID: 17673337
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model.
    Ciomei M; Croci V; Ciavolella A; Ballinari D; Pesenti E
    Clin Cancer Res; 2006 May; 12(9):2856-61. PubMed ID: 16675581
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor activity of edotecarin in breast carcinoma models.
    Ciomei M; Croci V; Stellari F; Amboldi N; Giavarini R; Pesenti E
    Cancer Chemother Pharmacol; 2007 Jul; 60(2):229-35. PubMed ID: 17089166
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, biological evaluation, and molecular modeling studies of rebeccamycin analogues modified in the carbohydrate moiety.
    Animati F; Berettoni M; Bigioni M; Binaschi M; Felicetti P; Gontrani L; Incani O; Madami A; Monteagudo E; Olivieri L; Resta S; Rossi C; Cipollone A
    ChemMedChem; 2008 Feb; 3(2):266-79. PubMed ID: 18157856
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
    Dallavalle S; Gattinoni S; Mazzini S; Scaglioni L; Merlini L; Tinelli S; Beretta GL; Zunino F
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1484-9. PubMed ID: 18248813
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors.
    Li Z; Zhai F; Zhao L; Guo Q; You Q
    Bioorg Med Chem Lett; 2009 Jan; 19(2):406-9. PubMed ID: 19058964
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors.
    Cho HJ; Jung MJ; Kwon Y; Na Y
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6766-9. PubMed ID: 19836231
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Syntheses and biological activities of rebeccamycin analogues with uncommon sugars.
    Zhang G; Shen J; Cheng H; Zhu L; Fang L; Luo S; Muller MT; Lee GE; Wei L; Du Y; Sun D; Wang PG
    J Med Chem; 2005 Apr; 48(7):2600-11. PubMed ID: 15801850
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
    Moreau P; Anizon F; Sancelme M; Prudhomme M; Sevère D; Riou JF; Goossens JF; Hénichart JP; Bailly C; Labourier E; Tazzi J; Fabbro D; Meyer T; Aubertin AM
    J Med Chem; 1999 May; 42(10):1816-22. PubMed ID: 10346933
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
    Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.
    Park HJ; Kim YS; Kim JS; Lee EJ; Yi YJ; Hwang HJ; Suh ME; Ryu CK; Lee SK
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3385-8. PubMed ID: 15177438
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
    Gao H; Zhang X; Chen Y; Shen H; Pang T; Sun J; Xu C; Ding J; Li C; Lu W
    Bioorg Med Chem Lett; 2005 Jul; 15(13):3233-6. PubMed ID: 15913996
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
    Moreau P; Anizon F; Sancelme M; Prudhomme M; Bailly C; Sevère D; Riou JF; Fabbro D; Meyer T; Aubertin AM
    J Med Chem; 1999 Feb; 42(4):584-92. PubMed ID: 10052965
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.
    Bacherikov VA; Chou TC; Dong HJ; Zhang X; Chen CH; Lin YW; Tsai TJ; Lee RZ; Liu LF; Su TL
    Bioorg Med Chem; 2005 Jun; 13(12):3993-4006. PubMed ID: 15911312
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and in vitro and in vivo evaluation of a series of dihydroisocoumarin derivatives conjugated with fatty acids, alcohols, and amines as potential anticancer agents.
    Higgins CA; Delbederi Z; McGarel K; Mills T; McGrath O; Feutren-Burton S; Watters W; Armstrong P; Johnston PG; Waugh D; van den Berg H
    Bioconjug Chem; 2009 Sep; 20(9):1737-51. PubMed ID: 19708666
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, DNA-binding affinity and cytotoxicity of the dinuclear platinum(II) complexes with berenil and amines ligands.
    Bielawski K; Bielawska A; Popławska B; Bołkun-Skórnicka U
    Acta Pol Pharm; 2008; 65(3):363-70. PubMed ID: 18646556
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.