270 related articles for article (PubMed ID: 19398331)
1. The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
McGuigan C; Daverio F; Nájera I; Martin JA; Klumpp K; Smith DB
Bioorg Med Chem Lett; 2009 Jun; 19(11):3122-4. PubMed ID: 19398331
[TBL] [Abstract][Full Text] [Related]
2. Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Perrone P; Luoni GM; Kelleher MR; Daverio F; Angell A; Mulready S; Congiatu C; Rajyaguru S; Martin JA; Levêque V; Le Pogam S; Najera I; Klumpp K; Smith DB; McGuigan C
J Med Chem; 2007 Apr; 50(8):1840-9. PubMed ID: 17367121
[TBL] [Abstract][Full Text] [Related]
3. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
McGuigan C; Gilles A; Madela K; Aljarah M; Holl S; Jones S; Vernachio J; Hutchins J; Ames B; Bryant KD; Gorovits E; Ganguly B; Hunley D; Hall A; Kolykhalov A; Liu Y; Muhammad J; Raja N; Walters R; Wang J; Chamberlain S; Henson G
J Med Chem; 2010 Jul; 53(13):4949-57. PubMed ID: 20527890
[TBL] [Abstract][Full Text] [Related]
4. First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Perrone P; Daverio F; Valente R; Rajyaguru S; Martin JA; Lévêque V; Le Pogam S; Najera I; Klumpp K; Smith DB; McGuigan C
J Med Chem; 2007 Nov; 50(22):5463-70. PubMed ID: 17914786
[TBL] [Abstract][Full Text] [Related]
5. The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
McGuigan C; Perrone P; Madela K; Neyts J
Bioorg Med Chem Lett; 2009 Aug; 19(15):4316-20. PubMed ID: 19523820
[TBL] [Abstract][Full Text] [Related]
6. Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
Gudmundsson KS; Wang Z; Daluge SM; Johnson LC; Hazen R; Condreay LD; McGuigan C
Nucleosides Nucleotides Nucleic Acids; 2004; 23(12):1929-37. PubMed ID: 15628749
[TBL] [Abstract][Full Text] [Related]
7. Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue.
Derudas M; Quintiliani M; Brancale A; Andrei G; Snoeck R; Balzarini J; McGuigan C
Antivir Chem Chemother; 2010 Oct; 21(1):15-31. PubMed ID: 21045257
[TBL] [Abstract][Full Text] [Related]
8. Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
Gudmundsson KS; Daluge SM; Johnson LC; Jansen R; Hazen R; Condreay LD; McGuigan C
Nucleosides Nucleotides Nucleic Acids; 2003 Oct; 22(10):1953-61. PubMed ID: 14609234
[TBL] [Abstract][Full Text] [Related]
9. Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
J Med Chem; ; . PubMed ID: 19725579
[TBL] [Abstract][Full Text] [Related]
10.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
11.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
12.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
13.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
14.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
15.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
16.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
17.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
18.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
19.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]