BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 19403924)

  • 1. New high-throughput fluorimetric assay for discovering inhibitors of UDP-N-acetylmuramyl-L-alanine: D-glutamate (MurD) ligase.
    Kristan K; Kotnik M; Oblak M; Urleb U
    J Biomol Screen; 2009 Apr; 14(4):412-8. PubMed ID: 19403924
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme.
    Humljan J; Kotnik M; Contreras-Martel C; Blanot D; Urleb U; Dessen A; Solmajer T; Gobec S
    J Med Chem; 2008 Dec; 51(23):7486-94. PubMed ID: 19007109
    [TBL] [Abstract][Full Text] [Related]  

  • 3. "Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.
    Bertrand JA; Fanchon E; Martin L; Chantalat L; Auger G; Blanot D; van Heijenoort J; Dideberg O
    J Mol Biol; 2000 Sep; 301(5):1257-66. PubMed ID: 10966819
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase.
    Tomasić T; Zidar N; Rupnik V; Kovac A; Blanot D; Gobec S; Kikelj D; Masic LP
    Bioorg Med Chem Lett; 2009 Jan; 19(1):153-7. PubMed ID: 19014883
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MurD enzymes from different bacteria: evaluation of inhibitors.
    Barreteau H; Sosič I; Turk S; Humljan J; Tomašić T; Zidar N; Hervé M; Boniface A; Peterlin-Mašič L; Kikelj D; Mengin-Lecreulx D; Gobec S; Blanot D
    Biochem Pharmacol; 2012 Sep; 84(5):625-32. PubMed ID: 22705647
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.
    Tomašić T; Kovač A; Simčič M; Blanot D; Grdadolnik SG; Gobec S; Kikelj D; Peterlin Mašič L
    Eur J Med Chem; 2011 Sep; 46(9):3964-75. PubMed ID: 21703731
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.
    Falk PJ; Ervin KM; Volk KS; Ho HT
    Biochemistry; 1996 Feb; 35(5):1417-22. PubMed ID: 8634271
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
    Bertrand JA; Auger G; Martin L; Fanchon E; Blanot D; Le Beller D; van Heijenoort J; Dideberg O
    J Mol Biol; 1999 Jun; 289(3):579-90. PubMed ID: 10356330
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase.
    Emanuele JJ; Jin H; Yanchunas J; Villafranca JJ
    Biochemistry; 1997 Jun; 36(23):7264-71. PubMed ID: 9188728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase.
    Kotnik M; Humljan J; Contreras-Martel C; Oblak M; Kristan K; Hervé M; Blanot D; Urleb U; Gobec S; Dessen A; Solmajer T
    J Mol Biol; 2007 Jun; 370(1):107-15. PubMed ID: 17507028
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF.
    Sova M; Kovac A; Turk S; Hrast M; Blanot D; Gobec S
    Bioorg Chem; 2009 Dec; 37(6):217-22. PubMed ID: 19804894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).
    Tomasić T; Zidar N; Sink R; Kovac A; Blanot D; Contreras-Martel C; Dessen A; Müller-Premru M; Zega A; Gobec S; Kikelj D; Masic LP
    J Med Chem; 2011 Jul; 54(13):4600-10. PubMed ID: 21591605
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MurD enzymes: some recent developments.
    Šink R; Barreteau H; Patin D; Mengin-Lecreulx D; Gobec S; Blanot D
    Biomol Concepts; 2013 Dec; 4(6):539-56. PubMed ID: 25436755
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
    Turk S; Kovac A; Boniface A; Bostock JM; Chopra I; Blanot D; Gobec S
    Bioorg Med Chem; 2009 Mar; 17(5):1884-9. PubMed ID: 19223185
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.
    Hrast M; Turk S; Sosič I; Knez D; Randall CP; Barreteau H; Contreras-Martel C; Dessen A; O'Neill AJ; Mengin-Lecreulx D; Blanot D; Gobec S
    Eur J Med Chem; 2013 Aug; 66():32-45. PubMed ID: 23786712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli.
    Bertrand JA; Auger G; Fanchon E; Martin L; Blanot D; van Heijenoort J; Dideberg O
    EMBO J; 1997 Jun; 16(12):3416-25. PubMed ID: 9218784
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitor design strategy based on an enzyme structural flexibility: a case of bacterial MurD ligase.
    Perdih A; Hrast M; Barreteau H; Gobec S; Wolber G; Solmajer T
    J Chem Inf Model; 2014 May; 54(5):1451-66. PubMed ID: 24724969
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MurD ligase from E. coli: Tetrahedral intermediate formation study by hybrid quantum mechanical/molecular mechanical replica path method.
    Perdih A; Hodoscek M; Solmajer T
    Proteins; 2009 Feb; 74(3):744-59. PubMed ID: 18704940
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE).
    Strancar K; Boniface A; Blanot D; Gobec S
    Arch Pharm (Weinheim); 2007 Mar; 340(3):127-34. PubMed ID: 17335103
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach.
    Perdih A; Kovac A; Wolber G; Blanot D; Gobec S; Solmajer T
    Bioorg Med Chem Lett; 2009 May; 19(10):2668-73. PubMed ID: 19369074
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.