327 related articles for article (PubMed ID: 19409780)
21. Evaluating scoring functions for docking and designing beta-secretase inhibitors.
Katharine Holloway M; McGaughey GB; Coburn CA; Stachel SJ; Jones KG; Stanton EL; Gregro AR; Lai MT; Crouthamel MC; Pietrak BL; Munshi SK
Bioorg Med Chem Lett; 2007 Feb; 17(3):823-7. PubMed ID: 17107793
[TBL] [Abstract][Full Text] [Related]
22. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
[TBL] [Abstract][Full Text] [Related]
23. Apo and inhibitor complex structures of BACE (beta-secretase).
Patel S; Vuillard L; Cleasby A; Murray CW; Yon J
J Mol Biol; 2004 Oct; 343(2):407-16. PubMed ID: 15451669
[TBL] [Abstract][Full Text] [Related]
24. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
Maillard MC; Hom RK; Benson TE; Moon JB; Mamo S; Bienkowski M; Tomasselli AG; Woods DD; Prince DB; Paddock DJ; Emmons TL; Tucker JA; Dappen MS; Brogley L; Thorsett ED; Jewett N; Sinha S; John V
J Med Chem; 2007 Feb; 50(4):776-81. PubMed ID: 17300163
[TBL] [Abstract][Full Text] [Related]
25. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Jennings LD; Cole DC; Stock JR; Sukhdeo MN; Ellingboe JW; Cowling R; Jin G; Manas ES; Fan KY; Malamas MS; Harrison BL; Jacobsen S; Chopra R; Lohse PA; Moore WJ; O'Donnell MM; Hu Y; Robichaud AJ; Turner MJ; Wagner E; Bard J
Bioorg Med Chem Lett; 2008 Jan; 18(2):767-71. PubMed ID: 18068983
[TBL] [Abstract][Full Text] [Related]
26. Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.
Tresadern G; Delgado F; Delgado O; Gijsen H; Macdonald GJ; Moechars D; Rombouts F; Alexander R; Spurlino J; Van Gool M; Vega JA; Trabanco AA
Bioorg Med Chem Lett; 2011 Dec; 21(24):7255-60. PubMed ID: 22071305
[TBL] [Abstract][Full Text] [Related]
27. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
Wyss DF; Wang YS; Eaton HL; Strickland C; Voigt JH; Zhu Z; Stamford AW
Top Curr Chem; 2012; 317():83-114. PubMed ID: 21647837
[TBL] [Abstract][Full Text] [Related]
28. Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening.
Xu W; Chen G; Zhu W; Zuo Z
Bioorg Med Chem Lett; 2010 Oct; 20(19):5763-6. PubMed ID: 20732815
[TBL] [Abstract][Full Text] [Related]
29. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
Kreft A; Harrison B; Aschmies S; Atchison K; Casebier D; Cole DC; Diamantidis G; Ellingboe J; Hauze D; Hu Y; Huryn D; Jin M; Kubrak D; Lu P; Lundquist J; Mann C; Martone R; Moore W; Oganesian A; Porte A; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Woller K; Xu Z; Zhou H; Steven Jacobsen J
Bioorg Med Chem Lett; 2008 Jul; 18(14):4232-6. PubMed ID: 18556202
[TBL] [Abstract][Full Text] [Related]
30. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Cole DC; Stock JR; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jennings LD; Jin G; Lohse PA; Malamas MS; Manas ES; Moore WJ; O'Donnell MM; Olland AM; Robichaud AJ; Svenson K; Wu J; Wagner E; Bard J
Bioorg Med Chem Lett; 2008 Feb; 18(3):1063-6. PubMed ID: 18162398
[TBL] [Abstract][Full Text] [Related]
31. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
[TBL] [Abstract][Full Text] [Related]
32. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Rueeger H; Rondeau JM; McCarthy C; Möbitz H; Tintelnot-Blomley M; Neumann U; Desrayaud S
Bioorg Med Chem Lett; 2011 Apr; 21(7):1942-7. PubMed ID: 21388807
[TBL] [Abstract][Full Text] [Related]
33. Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
Congreve M; Aharony D; Albert J; Callaghan O; Campbell J; Carr RA; Chessari G; Cowan S; Edwards PD; Frederickson M; McMenamin R; Murray CW; Patel S; Wallis N
J Med Chem; 2007 Mar; 50(6):1124-32. PubMed ID: 17315857
[TBL] [Abstract][Full Text] [Related]
34. BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Clarke B; Cutler L; Demont E; Dingwall C; Dunsdon R; Hawkins J; Howes C; Hussain I; Maile G; Matico R; Mosley J; Naylor A; O'Brien A; Redshaw S; Rowland P; Soleil V; Smith KJ; Sweitzer S; Theobald P; Vesey D; Walter DS; Wayne G
Bioorg Med Chem Lett; 2010 Aug; 20(15):4639-44. PubMed ID: 20579874
[TBL] [Abstract][Full Text] [Related]
35. Progress toward a practical BACE-1 inhibitor.
Hills ID; Vacca JP
Curr Opin Drug Discov Devel; 2007 Jul; 10(4):383-91. PubMed ID: 17659479
[TBL] [Abstract][Full Text] [Related]
36. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G
Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276
[TBL] [Abstract][Full Text] [Related]
37. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
[TBL] [Abstract][Full Text] [Related]
38. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
[TBL] [Abstract][Full Text] [Related]
39. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
Stachel SJ; Coburn CA; Steele TG; Jones KG; Loutzenhiser EF; Gregro AR; Rajapakse HA; Lai MT; Crouthamel MC; Xu M; Tugusheva K; Lineberger JE; Pietrak BL; Espeseth AS; Shi XP; Chen-Dodson E; Holloway MK; Munshi S; Simon AJ; Kuo L; Vacca JP
J Med Chem; 2004 Dec; 47(26):6447-50. PubMed ID: 15588077
[TBL] [Abstract][Full Text] [Related]
40. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Thompson LA; Shi J; Decicco CP; Tebben AJ; Olson RE; Boy KM; Guernon JM; Good AC; Liauw A; Zheng C; Copeland RA; Combs AP; Trainor GL; Camac DM; Muckelbauer JK; Lentz KA; Grace JE; Burton CR; Toyn JH; Barten DM; Marcinkeviciene J; Meredith JE; Albright CF; Macor JE
Bioorg Med Chem Lett; 2011 Nov; 21(22):6909-15. PubMed ID: 21974952
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
