BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 19426697)

  • 1. Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.
    Karczewski J; Wang J; Kane SA; Kiss L; Koblan KS; Culberson JC; Spencer RH
    Biochem Pharmacol; 2009 May; 77(10):1602-11. PubMed ID: 19426697
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.
    Gordon E; Lozinskaya IM; Lin Z; Semus SF; Blaney FE; Willette RN; Xu X
    Mol Pharmacol; 2008 Mar; 73(3):639-51. PubMed ID: 18042732
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels.
    Perrin MJ; Kuchel PW; Campbell TJ; Vandenberg JI
    Mol Pharmacol; 2008 Nov; 74(5):1443-52. PubMed ID: 18701618
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [HERG K+ channel, the target of anti-arrhythmias drugs].
    Guan FY; Yang SJ
    Yao Xue Xue Bao; 2007 Jul; 42(7):687-91. PubMed ID: 17882949
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of HERG channels by the local anaesthetic articaine.
    Siebrands CC; Friederich P
    Eur J Anaesthesiol; 2007 Feb; 24(2):148-53. PubMed ID: 16938156
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.
    Lu Y; Mahaut-Smith MP; Huang CL; Vandenberg JI
    J Physiol; 2003 Aug; 551(Pt 1):253-62. PubMed ID: 12923204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain.
    Duan JJ; Ma JH; Zhang PH; Wang XP; Zou AR; Tu DN
    Acta Pharmacol Sin; 2007 Jul; 28(7):959-67. PubMed ID: 17588331
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
    Mitcheson JS; Chen J; Sanguinetti MC
    J Gen Physiol; 2000 Mar; 115(3):229-40. PubMed ID: 10694252
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.
    Su Z; Chen J; Martin RL; McDermott JS; Cox BF; Gopalakrishnan M; Gintant GA
    Biochem Pharmacol; 2006 Jan; 71(3):278-86. PubMed ID: 16325148
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.
    Imai YN; Ryu S; Oiki S
    J Med Chem; 2009 Mar; 52(6):1630-8. PubMed ID: 19260734
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel.
    Hancox JC; James AF
    Mol Pharmacol; 2008 Jun; 73(6):1592-5. PubMed ID: 18381562
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Toward a consensus model of the HERG potassium channel.
    Stary A; Wacker SJ; Boukharta L; Zachariae U; Karimi-Nejad Y; Aqvist J; Vriend G; de Groot BL
    ChemMedChem; 2010 Mar; 5(3):455-67. PubMed ID: 20104563
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular determinants of HERG channel block.
    Kamiya K; Niwa R; Mitcheson JS; Sanguinetti MC
    Mol Pharmacol; 2006 May; 69(5):1709-16. PubMed ID: 16474003
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural determinants of HERG channel block by clofilium and ibutilide.
    Perry M; de Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J
    Mol Pharmacol; 2004 Aug; 66(2):240-9. PubMed ID: 15266014
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of the first sulfur-35-labeled hERG radioligand.
    Raab CE; Butcher JW; Connolly TM; Karczewski J; Yu NX; Staskiewicz SJ; Liverton N; Dean DC; Melillo DG
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1692-5. PubMed ID: 16377185
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition.
    Yi H; Cao Z; Yin S; Dai C; Wu Y; Li W
    J Proteome Res; 2007 Feb; 6(2):611-20. PubMed ID: 17269718
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Na+ permeation and block of hERG potassium channels.
    Gang H; Zhang S
    J Gen Physiol; 2006 Jul; 128(1):55-71. PubMed ID: 16769794
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.
    Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS
    Mol Pharmacol; 2004 Nov; 66(5):1201-12. PubMed ID: 15308760
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular determinants of hERG channel block by terfenadine and cisapride.
    Kamiya K; Niwa R; Morishima M; Honjo H; Sanguinetti MC
    J Pharmacol Sci; 2008 Nov; 108(3):301-7. PubMed ID: 18987434
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
    Zachariae U; Giordanetto F; Leach AG
    J Med Chem; 2009 Jul; 52(14):4266-76. PubMed ID: 19534531
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.