219 related articles for article (PubMed ID: 19426743)
1. Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.
Seiradake E; Mao W; Hernandez V; Baker SJ; Plattner JJ; Alley MR; Cusack S
J Mol Biol; 2009 Jul; 390(2):196-207. PubMed ID: 19426743
[TBL] [Abstract][Full Text] [Related]
2. Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690.
Zhou XL; Tan M; Wang M; Chen X; Wang ED
Biochem J; 2010 Sep; 430(2):325-33. PubMed ID: 20557293
[TBL] [Abstract][Full Text] [Related]
3. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.
Rock FL; Mao W; Yaremchuk A; Tukalo M; Crépin T; Zhou H; Zhang YK; Hernandez V; Akama T; Baker SJ; Plattner JJ; Shapiro L; Martinis SA; Benkovic SJ; Cusack S; Alley MR
Science; 2007 Jun; 316(5832):1759-61. PubMed ID: 17588934
[TBL] [Abstract][Full Text] [Related]
4. Deciphering the interaction of benzoxaborole inhibitor AN2690 with connective polypeptide 1 (CP1) editing domain of
Tandon S; Manhas R; Tiwari N; Munde M; Vijayan R; Gourinath S; Muthuswami R; Madhubala R
J Biosci; 2020; 45():. PubMed ID: 32385222
[TBL] [Abstract][Full Text] [Related]
5. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.
Zhao H; Palencia A; Seiradake E; Ghaemi Z; Cusack S; Luthey-Schulten Z; Martinis S
ACS Chem Biol; 2015 Oct; 10(10):2277-85. PubMed ID: 26172575
[TBL] [Abstract][Full Text] [Related]
6. Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap.
Sarkar J; Mao W; Lincecum TL; Alley MR; Martinis SA
FEBS Lett; 2011 Oct; 585(19):2986-91. PubMed ID: 21856301
[TBL] [Abstract][Full Text] [Related]
7. Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination.
Liu Y; Liao J; Zhu B; Wang ED; Ding J
Biochem J; 2006 Mar; 394(Pt 2):399-407. PubMed ID: 16277600
[TBL] [Abstract][Full Text] [Related]
8. Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation.
Fukunaga R; Yokoyama S
J Mol Biol; 2005 Feb; 346(1):57-71. PubMed ID: 15663927
[TBL] [Abstract][Full Text] [Related]
9. Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: two amino acid binding sites in the editing domain.
Lee KW; Briggs JM
Proteins; 2004 Mar; 54(4):693-704. PubMed ID: 14997565
[TBL] [Abstract][Full Text] [Related]
10. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Palencia A; Liu RJ; Lukarska M; Gut J; Bougdour A; Touquet B; Wang ED; Li X; Alley MR; Freund YR; Rosenthal PJ; Hakimi MA; Cusack S
Antimicrob Agents Chemother; 2016 Oct; 60(10):5817-27. PubMed ID: 27431220
[TBL] [Abstract][Full Text] [Related]
11. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase.
Hu QH; Liu RJ; Fang ZP; Zhang J; Ding YY; Tan M; Wang M; Pan W; Zhou HC; Wang ED
Sci Rep; 2013; 3():2475. PubMed ID: 23959225
[TBL] [Abstract][Full Text] [Related]
12. A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases.
Hsu JL; Martinis SA
J Mol Biol; 2008 Feb; 376(2):482-91. PubMed ID: 18155724
[TBL] [Abstract][Full Text] [Related]
13. The C-terminal domain of the archaeal leucyl-tRNA synthetase prevents misediting of isoleucyl-tRNA(Ile).
Fukunaga R; Yokoyama S
Biochemistry; 2007 May; 46(17):4985-96. PubMed ID: 17407269
[TBL] [Abstract][Full Text] [Related]
14. Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition.
Fukunaga R; Yokoyama S
Nat Struct Mol Biol; 2005 Oct; 12(10):915-22. PubMed ID: 16155584
[TBL] [Abstract][Full Text] [Related]
15. Molecular modeling and molecular dynamics simulation study of archaeal leucyl-tRNA synthetase in complex with different mischarged tRNA in editing conformation.
Rayevsky AV; Sharifi M; Tukalo MA
J Mol Graph Model; 2017 Sep; 76():289-295. PubMed ID: 28743072
[TBL] [Abstract][Full Text] [Related]
16. C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu.
Ji QQ; Fang ZP; Ye Q; Ruan ZR; Zhou XL; Wang ED
J Biol Chem; 2016 Feb; 291(7):3613-25. PubMed ID: 26677220
[TBL] [Abstract][Full Text] [Related]
17. Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editing.
Zhou XL; Wang ED
Biochem Biophys Res Commun; 2009 Aug; 386(3):510-5. PubMed ID: 19540202
[TBL] [Abstract][Full Text] [Related]
18. Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity.
Zhou XL; Fang ZP; Ruan ZR; Wang M; Liu RJ; Tan M; Anella FM; Wang ED
Nucleic Acids Res; 2013 Nov; 41(21):9825-38. PubMed ID: 23969415
[TBL] [Abstract][Full Text] [Related]
19. Leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus recognizes minihelices.
Xu MG; Zhao MW; Wang ED
J Biol Chem; 2004 Jul; 279(31):32151-8. PubMed ID: 15161932
[TBL] [Abstract][Full Text] [Related]
20. Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity.
Betha AK; Williams AM; Martinis SA
Biochemistry; 2007 May; 46(21):6258-67. PubMed ID: 17474713
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
