BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

293 related articles for article (PubMed ID: 19431162)

  • 1. Synthesis and biological evaluation of c7-demethyl largazole analogues.
    Chen F; Gao AH; Li J; Nan FJ
    ChemMedChem; 2009 Aug; 4(8):1269-72. PubMed ID: 19431162
    [No Abstract]   [Full Text] [Related]  

  • 2. Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
    Souto JA; Vaz E; Lepore I; Pöppler AC; Franci G; Alvarez R; Altucci L; de Lera AR
    J Med Chem; 2010 Jun; 53(12):4654-67. PubMed ID: 20491440
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.
    Benelkebir H; Marie S; Hayden AL; Lyle J; Loadman PM; Crabb SJ; Packham G; Ganesan A
    Bioorg Med Chem; 2011 Jun; 19(12):3650-8. PubMed ID: 21420302
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
    Ying Y; Taori K; Kim H; Hong J; Luesch H
    J Am Chem Soc; 2008 Jul; 130(26):8455-9. PubMed ID: 18507379
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and activity of largazole analogues with linker and macrocycle modification.
    Ying Y; Liu Y; Byeon SR; Kim H; Luesch H; Hong J
    Org Lett; 2008 Sep; 10(18):4021-4. PubMed ID: 18707106
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
    Bhansali P; Hanigan CL; Casero RA; Tillekeratne LM
    J Med Chem; 2011 Nov; 54(21):7453-63. PubMed ID: 21936551
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.
    Poli G; Di Fabio R; Ferrante L; Summa V; Botta M
    ChemMedChem; 2017 Dec; 12(23):1917-1926. PubMed ID: 29117473
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole.
    Taori K; Liu Y; Paul VJ; Luesch H
    Chembiochem; 2009 Jul; 10(10):1634-9. PubMed ID: 19514039
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological activity of largazole and derivatives.
    Seiser T; Kamena F; Cramer N
    Angew Chem Int Ed Engl; 2008; 47(34):6483-5. PubMed ID: 18633950
    [No Abstract]   [Full Text] [Related]  

  • 10. Synthesis and biological evaluation of largazole zinc-binding group analogs.
    Kim B; Ratnayake R; Lee H; Shi G; Zeller SL; Li C; Luesch H; Hong J
    Bioorg Med Chem; 2017 Jun; 25(12):3077-3086. PubMed ID: 28416100
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.
    Reddy DN; Ballante F; Chuang T; Pirolli A; Marrocco B; Marshall GR
    J Med Chem; 2016 Feb; 59(4):1613-33. PubMed ID: 26681404
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
    Guerra-Bubb JM; Bowers AA; Smith WB; Paranal R; Estiu G; Wiest O; Bradner JE; Williams RM
    Bioorg Med Chem Lett; 2013 Nov; 23(21):6025-8. PubMed ID: 24035339
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.
    Andrews DM; Stokes ES; Carr GR; Matusiak ZS; Roberts CA; Waring MJ; Brady MC; Chresta CM; East SJ
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2580-4. PubMed ID: 18378449
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.
    Li S; Yao H; Xu J; Jiang S
    Molecules; 2011 Jun; 16(6):4681-94. PubMed ID: 21654576
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.
    Bhansali P; Hanigan CL; Perera L; Casero RA; Tillekeratne LM
    Eur J Med Chem; 2014 Oct; 86():528-41. PubMed ID: 25203782
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells.
    Zeng X; Yin B; Hu Z; Liao C; Liu J; Li S; Li Z; Nicklaus MC; Zhou G; Jiang S
    Org Lett; 2010 Mar; 12(6):1368-71. PubMed ID: 20184338
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.
    Almaliti J; Al-Hamashi AA; Negmeldin AT; Hanigan CL; Perera L; Pflum MK; Casero RA; Tillekeratne LM
    J Med Chem; 2016 Dec; 59(23):10642-10660. PubMed ID: 27809521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
    Clausen DJ; Smith WB; Haines BE; Wiest O; Bradner JE; Williams RM
    Bioorg Med Chem; 2015 Aug; 23(15):5061-5074. PubMed ID: 26054247
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues.
    Wang Y; Zhang F; Zhang Y; Liu JO; Ma D
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4385-7. PubMed ID: 18606540
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
    Bowers AA; West N; Newkirk TL; Troutman-Youngman AE; Schreiber SL; Wiest O; Bradner JE; Williams RM
    Org Lett; 2009 Mar; 11(6):1301-4. PubMed ID: 19239241
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.