These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

104 related articles for article (PubMed ID: 19442519)

  • 1. The discovery of novel calcium sensing receptor negative allosteric modulators.
    Balan G; Bauman J; Bhattacharya S; Castrodad M; Healy DR; Herr M; Humphries P; Jennings S; Kalgutkar AS; Kapinos B; Khot V; Lazarra K; Li M; Li Y; Neagu C; Oliver R; Piotrowski DW; Price D; Qi H; Simmons HA; Southers J; Wei L; Zhang Y; Paralkar VM
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3328-32. PubMed ID: 19442519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists.
    Yang W; Ruan Z; Wang Y; Van Kirk K; Ma Z; Arey BJ; Cooper CB; Seethala R; Feyen JH; Dickson JK
    J Med Chem; 2009 Feb; 52(4):1204-8. PubMed ID: 19143533
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women.
    Caltabiano S; Dollery CT; Hossain M; Kurtinecz MT; Desjardins JP; Favus MJ; Kumar R; Fitzpatrick LA
    Bone; 2013 Sep; 56(1):154-62. PubMed ID: 23756230
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.
    Kumar S; Matheny CJ; Hoffman SJ; Marquis RW; Schultz M; Liang X; Vasko JA; Stroup GB; Vaden VR; Haley H; Fox J; DelMar EG; Nemeth EF; Lago AM; Callahan JF; Bhatnagar P; Huffman WF; Gowen M; Yi B; Danoff TM; Fitzpatrick LA
    Bone; 2010 Feb; 46(2):534-42. PubMed ID: 19786130
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure based evolution of a novel series of positive modulators of the AMPA receptor.
    Jamieson C; Maclean JK; Brown CI; Campbell RA; Gillen KJ; Gillespie J; Kazemier B; Kiczun M; Lamont Y; Lyons AJ; Moir EM; Morrow JA; Pantling J; Rankovic Z; Smith L
    Bioorg Med Chem Lett; 2011 Jan; 21(2):805-11. PubMed ID: 21190850
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis.
    Liang GB; Zhou C; Huo X; Wang H; Yang X; Huang S; Wang H; Wilkinson H; Luo L; Tang W; Sutton D; Li H; Zaller D; Meinke PT
    Bioorg Med Chem Lett; 2016 Aug; 26(16):4077-80. PubMed ID: 27397499
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis.
    Widler L
    Future Med Chem; 2011 Apr; 3(5):535-47. PubMed ID: 21526895
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.
    Yoshida M; Mori A; Morimoto S; Kotani E; Oka M; Notoya K; Makino H; Ono M; Shirasaki M; Tada N; Fujita H; Ban J; Ikeda Y; Kawamoto T; Goto M; Kimura H; Baba A; Yasuma T
    Bioorg Med Chem; 2011 Mar; 19(6):1881-94. PubMed ID: 21353570
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: results of a randomized, double-blinded, placebo-controlled Phase II clinical trial.
    Fitzpatrick LA; Smith PL; McBride TA; Fries MA; Hossain M; Dabrowski CE; Gordon DN
    Bone; 2011 Oct; 49(4):845-52. PubMed ID: 21742071
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
    Kalgutkar AS; Griffith DA; Ryder T; Sun H; Miao Z; Bauman JN; Didiuk MT; Frederick KS; Zhao SX; Prakash C; Soglia JR; Bagley SW; Bechle BM; Kelley RM; Dirico K; Zawistoski M; Li J; Oliver R; Guzman-Perez A; Liu KK; Walker DP; Benbow JW; Morris J
    Chem Res Toxicol; 2010 Jun; 23(6):1115-26. PubMed ID: 20507089
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma.
    Yarova PL; Huang P; Schepelmann MW; Bruce R; Ecker R; Nica R; Telezhkin V; Traini D; Gomes Dos Reis L; Kidd EJ; Ford WR; Broadley KJ; Kariuki BM; Corrigan CJ; Ward JPT; Kemp PJ; Riccardi D
    J Pharmacol Exp Ther; 2021 Jan; 376(1):51-63. PubMed ID: 33115824
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.
    Marquis RW; Lago AM; Callahan JF; Rahman A; Dong X; Stroup GB; Hoffman S; Gowen M; DelMar EG; Van Wagenen BC; Logan S; Shimizu S; Fox J; Nemeth EF; Roethke T; Smith BR; Ward KW; Bhatnagar P
    J Med Chem; 2009 Nov; 52(21):6599-605. PubMed ID: 19821575
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.
    Gustafsson M; Jensen J; Bertozzi SM; Currier EA; Ma JN; Burstein ES; Olsson R
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5918-21. PubMed ID: 20727747
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration.
    Eskildsen J; Redrobe JP; Sams AG; Dekermendjian K; Laursen M; Boll JB; Papke RL; Bundgaard C; Frederiksen K; Bastlund JF
    Bioorg Med Chem Lett; 2014 Jan; 24(1):288-93. PubMed ID: 24291041
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.
    Gavai AV; Vaz RJ; Mikkilineni AB; Roberge JY; Liu Y; Lawrence RM; Corte JR; Yang W; Bednarz M; Dickson JK; Ma Z; Seethala R; Feyen JH
    Bioorg Med Chem Lett; 2005 Dec; 15(24):5478-82. PubMed ID: 16216508
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis.
    Marie PJ
    Bone; 2010 Mar; 46(3):571-6. PubMed ID: 19660583
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications.
    Saidak Z; Brazier M; Kamel S; Mentaverri R
    Mol Pharmacol; 2009 Dec; 76(6):1131-44. PubMed ID: 19779033
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.
    Didiuk MT; Griffith DA; Benbow JW; Liu KK; Walker DP; Bi FC; Morris J; Guzman-Perez A; Gao H; Bechle BM; Kelley RM; Yang X; Dirico K; Ahmed S; Hungerford W; DiBrinno J; Zawistoski MP; Bagley SW; Li J; Zeng Y; Santucci S; Oliver R; Corbett M; Olson T; Chen C; Li M; Paralkar VM; Riccardi KA; Healy DR; Kalgutkar AS; Maurer TS; Nguyen HT; Frederick KS
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4555-9. PubMed ID: 19625189
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.
    Marquis RW; Lago AM; Callahan JF; Trout RE; Gowen M; DelMar EG; Van Wagenen BC; Logan S; Shimizu S; Fox J; Nemeth EF; Yang Z; Roethke T; Smith BR; Ward KW; Lee J; Keenan RM; Bhatnagar P
    J Med Chem; 2009 Jul; 52(13):3982-93. PubMed ID: 19492813
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Investigational anabolic therapies for osteoporosis.
    Trivedi R; Goswami R; Chattopadhyay N
    Expert Opin Investig Drugs; 2010 Aug; 19(8):995-1005. PubMed ID: 20629616
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.