193 related articles for article (PubMed ID: 19447612)
1. Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH; Wang D; Prashad AS; Subrath J; Wu B; Niu C; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Jul; 19(13):3623-6. PubMed ID: 19447612
[TBL] [Abstract][Full Text] [Related]
2. C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.
Subrath J; Wang D; Wu B; Niu C; Boschelli DH; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Sep; 19(18):5423-5. PubMed ID: 19682896
[TBL] [Abstract][Full Text] [Related]
3. C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
Prashad AS; Wang D; Subrath J; Wu B; Lin M; Zhang MY; Kagan N; Lee J; Yang X; Brennan A; Chaudhary D; Xu X; Leung L; Wang J; Boschelli DH
Bioorg Med Chem Lett; 2009 Oct; 19(19):5799-802. PubMed ID: 19703774
[TBL] [Abstract][Full Text] [Related]
4. First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Niu C; Boschelli DH; Tumey LN; Bhagirath N; Subrath J; Shim J; Wang Y; Wu B; Eid C; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Oct; 19(20):5829-32. PubMed ID: 19762237
[TBL] [Abstract][Full Text] [Related]
5. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Cole DC; Asselin M; Brennan A; Czerwinski R; Ellingboe JW; Fitz L; Greco R; Huang X; Joseph-McCarthy D; Kelly MF; Kirisits M; Lee J; Li Y; Morgan P; Stock JR; Tsao DH; Wissner A; Yang X; Chaudhary D
J Med Chem; 2008 Oct; 51(19):5958-63. PubMed ID: 18783200
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
Shim J; Eid C; Lee J; Liu E; Chaudhary D; Boschelli DH
Bioorg Med Chem Lett; 2009 Dec; 19(23):6575-7. PubMed ID: 19854645
[TBL] [Abstract][Full Text] [Related]
7. 5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: optimization of enzymatic and functional activity.
Tumey LN; Bhagirath N; Brennan A; Brooijmans N; Lee J; Yang X; Boschelli DH
Bioorg Med Chem; 2009 Dec; 17(23):7933-48. PubMed ID: 19884013
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.
Boschelli DH; Wu B; Barrios Sosa AC; Chen J; Asselin M; Cole DC; Lee J; Yang X; Chaudhary D
Bioorg Med Chem Lett; 2008 May; 18(9):2850-3. PubMed ID: 18434148
[TBL] [Abstract][Full Text] [Related]
9. Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH; Subrath J; Niu C; Wu B; Wang Y; Lee J; Brennan A; Ho M; Deng B; Yang X; Xu X; Leung L; Wang J; Atherton J; Chaudhary D
Bioorg Med Chem Lett; 2010 Mar; 20(6):1965-8. PubMed ID: 20153643
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
Dushin RG; Nittoli T; Ingalls C; Boschelli DH; Cole DC; Wissner A; Lee J; Yang X; Morgan P; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 May; 19(9):2461-3. PubMed ID: 19345579
[TBL] [Abstract][Full Text] [Related]
11. Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors.
Wu B; Boschelli DH; Lee J; Yang X; Chaudhary D
Bioorg Med Chem Lett; 2009 Feb; 19(3):766-9. PubMed ID: 19111463
[TBL] [Abstract][Full Text] [Related]
12. 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta.
Nathan Tumey L; Boschelli DH; Lee J; Chaudhary D
Bioorg Med Chem Lett; 2008 Aug; 18(15):4420-3. PubMed ID: 18606543
[TBL] [Abstract][Full Text] [Related]
13. Structure-based optimization of PKCtheta inhibitors.
Mosyak L; Xu Z; Joseph-McCarthy D; Brooijmans N; Somers W; Chaudhary D
Biochem Soc Trans; 2007 Nov; 35(Pt 5):1027-31. PubMed ID: 17956269
[TBL] [Abstract][Full Text] [Related]
14. Exploring the structure requirement for PKCθ inhibitory activity of pyridinecarbonitrile derivatives: an in silico analysis.
Li Y; Hao M; Ren H; Zhang S; Wang X; Ma M; Li G; Yang L
J Mol Graph Model; 2012 Apr; 34():76-88. PubMed ID: 22306416
[TBL] [Abstract][Full Text] [Related]
15. In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.
Wang T; Ioannidis S; Almeida L; Block MH; Davies AM; Lamb ML; Scott DA; Su M; Zhang HJ; Alimzhanov M; Bebernitz G; Bell K; Zinda M
Bioorg Med Chem Lett; 2011 May; 21(10):2958-61. PubMed ID: 21493067
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Hayakawa M; Kawaguchi K; Kaizawa H; Koizumi T; Ohishi T; Yamano M; Okada M; Ohta M; Tsukamoto S; Raynaud FI; Parker P; Workman P; Waterfield MD
Bioorg Med Chem; 2007 Sep; 15(17):5837-44. PubMed ID: 17601739
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
Kassis P; Brzeszcz J; Bénéteau V; Lozach O; Meijer L; Le Guével R; Guillouzo C; Lewiński K; Bourg S; Colliandre L; Routier S; Mérour JY
Eur J Med Chem; 2011 Nov; 46(11):5416-34. PubMed ID: 21944287
[TBL] [Abstract][Full Text] [Related]
18. Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.
Jimenez JM; Boyall D; Brenchley G; Collier PN; Davis CJ; Fraysse D; Keily SB; Henderson J; Miller A; Pierard F; Settimo L; Twin HC; Bolton CM; Curnock AP; Chiu P; Tanner AJ; Young S
J Med Chem; 2013 Mar; 56(5):1799-810. PubMed ID: 23398373
[TBL] [Abstract][Full Text] [Related]
19. Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
Ermoli A; Bargiotti A; Brasca MG; Ciavolella A; Colombo N; Fachin G; Isacchi A; Menichincheri M; Molinari A; Montagnoli A; Pillan A; Rainoldi S; Sirtori FR; Sola F; Thieffine S; Tibolla M; Valsasina B; Volpi D; Santocanale C; Vanotti E
J Med Chem; 2009 Jul; 52(14):4380-90. PubMed ID: 19555113
[TBL] [Abstract][Full Text] [Related]
20. Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Sisko JT; Tucker TJ; Bilodeau MT; Buser CA; Ciecko PA; Coll KE; Fernandes C; Gibbs JB; Koester TJ; Kohl N; Lynch JJ; Mao X; McLoughlin D; Miller-Stein CM; Rodman LD; Rickert KW; Sepp-Lorenzino L; Shipman JM; Thomas KA; Wong BK; Hartman GD
Bioorg Med Chem Lett; 2006 Mar; 16(5):1146-50. PubMed ID: 16368234
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
