These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 19452598)

  • 1. The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
    Langdown J; Belzar KJ; Savory WJ; Baglin TP; Huntington JA
    J Mol Biol; 2009 Mar; 386(5):1278-89. PubMed ID: 19452598
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric activation of antithrombin critically depends upon hinge region extension.
    Langdown J; Johnson DJ; Baglin TP; Huntington JA
    J Biol Chem; 2004 Nov; 279(45):47288-97. PubMed ID: 15326167
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes.
    Schedin-Weiss S; Richard B; Olson ST
    Arch Biochem Biophys; 2010 Dec; 504(2):169-76. PubMed ID: 20816747
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes.
    Futamura A; Beechem JM; Gettins PG
    Biochemistry; 2001 Jun; 40(22):6680-7. PubMed ID: 11380263
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of antithrombin in a heparin-bound intermediate state.
    Johnson DJ; Huntington JA
    Biochemistry; 2003 Jul; 42(29):8712-9. PubMed ID: 12873131
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of Arg46 and Arg47 of antithrombin in heparin binding.
    Arocas V; Bock SC; Olson ST; Björk I
    Biochemistry; 1999 Aug; 38(31):10196-204. PubMed ID: 10433728
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139.
    Arocas V; Turk B; Bock SC; Olson ST; Björk I
    Biochemistry; 2000 Jul; 39(29):8512-8. PubMed ID: 10913257
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin.
    Izaguirre G; Swanson R; Raja SM; Rezaie AR; Olson ST
    J Biol Chem; 2007 Nov; 282(46):33609-33622. PubMed ID: 17875649
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.
    Dementiev A; Swanson R; Roth R; Isetti G; Izaguirre G; Olson ST; Gettins PGW
    J Biol Chem; 2013 Nov; 288(47):33611-33619. PubMed ID: 24068708
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement.
    Olson ST; Björk I; Sheffer R; Craig PA; Shore JD; Choay J
    J Biol Chem; 1992 Jun; 267(18):12528-38. PubMed ID: 1618758
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.
    Chuang YJ; Swanson R; Raja SM; Olson ST
    J Biol Chem; 2001 May; 276(18):14961-71. PubMed ID: 11278930
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions.
    Huntington JA; McCoy A; Belzar KJ; Pei XY; Gettins PG; Carrell RW
    J Biol Chem; 2000 May; 275(20):15377-83. PubMed ID: 10809774
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.
    Schedin-Weiss S; Desai UR; Bock SC; Olson ST; Björk I
    Biochemistry; 2004 Jan; 43(3):675-83. PubMed ID: 14730971
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Helix D elongation and allosteric activation of antithrombin.
    Belzar KJ; Zhou A; Carrell RW; Gettins PG; Huntington JA
    J Biol Chem; 2002 Mar; 277(10):8551-8. PubMed ID: 11741963
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators.
    Gunnarsson GT; Desai UR
    J Med Chem; 2002 Sep; 45(20):4460-70. PubMed ID: 12238925
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation.
    Richard B; Swanson R; Olson ST
    J Biol Chem; 2009 Oct; 284(40):27054-64. PubMed ID: 19661062
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The influence of hinge region residue Glu-381 on antithrombin allostery and metastability.
    Johnson DJ; Huntington JA
    J Biol Chem; 2004 Feb; 279(6):4913-21. PubMed ID: 14623882
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies.
    Rezaie AR; Olson ST
    Biochemistry; 2000 Oct; 39(39):12083-90. PubMed ID: 11009624
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
    Izaguirre G; Aguila S; Qi L; Swanson R; Roth R; Rezaie AR; Gettins PG; Olson ST
    J Biol Chem; 2014 Dec; 289(49):34049-64. PubMed ID: 25331949
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The mechanism of high affinity pentasaccharide binding to antithrombin, insights from Gaussian accelerated molecular dynamics simulations.
    Balogh G; Komáromi I; Bereczky Z
    J Biomol Struct Dyn; 2020 Oct; 38(16):4718-4732. PubMed ID: 31686597
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.