189 related articles for article (PubMed ID: 19457662)
1. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
de Vicente J; Hendricks RT; Smith DB; Fell JB; Fischer J; Spencer SR; Stengel PJ; Mohr P; Robinson JE; Blake JF; Hilgenkamp RK; Yee C; Adjabeng G; Elworthy TR; Tracy J; Chin E; Li J; Wang B; Bamberg JT; Stephenson R; Oshiro C; Harris SF; Ghate M; Leveque V; Najera I; Le Pogam S; Rajyaguru S; Ao-Ieong G; Alexandrova L; Larrabee S; Brandl M; Briggs A; Sukhtankar S; Farrell R; Xu B
Bioorg Med Chem Lett; 2009 Jul; 19(13):3642-6. PubMed ID: 19457662
[TBL] [Abstract][Full Text] [Related]
2. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
[TBL] [Abstract][Full Text] [Related]
3. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
de Vicente J; Hendricks RT; Smith DB; Fell JB; Fischer J; Spencer SR; Stengel PJ; Mohr P; Robinson JE; Blake JF; Hilgenkamp RK; Yee C; Zhao J; Elworthy TR; Tracy J; Chin E; Li J; Lui A; Wang B; Oshiro C; Harris SF; Ghate M; Leveque VJ; Najera I; Le Pogam S; Rajyaguru S; Ao-Ieong G; Alexandrova L; Fitch B; Brandl M; Masjedizadeh M; Wu SY; de Keczer S; Voronin T
Bioorg Med Chem Lett; 2009 Oct; 19(19):5648-51. PubMed ID: 19700319
[TBL] [Abstract][Full Text] [Related]
4. Quinolones as HCV NS5B polymerase inhibitors.
Kumar DV; Rai R; Brameld KA; Somoza JR; Rajagopalan R; Janc JW; Xia YM; Ton TL; Shaghafi MB; Hu H; Lehoux I; To N; Young WB; Green MJ
Bioorg Med Chem Lett; 2011 Jan; 21(1):82-7. PubMed ID: 21145235
[TBL] [Abstract][Full Text] [Related]
5. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
de Vicente J; Hendricks RT; Smith DB; Fell JB; Fischer J; Spencer SR; Stengel PJ; Mohr P; Robinson JE; Blake JF; Hilgenkamp RK; Yee C; Adjabeng G; Elworthy TR; Li J; Wang B; Bamberg JT; Harris SF; Wong A; Leveque VJ; Najera I; Le Pogam S; Rajyaguru S; Ao-Ieong G; Alexandrova L; Larrabee S; Brandl M; Briggs A; Sukhtankar S; Farrell R
Bioorg Med Chem Lett; 2009 Oct; 19(19):5652-6. PubMed ID: 19709881
[TBL] [Abstract][Full Text] [Related]
6. Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.
Cheng Y; Shen J; Peng RZ; Wang GF; Zuo JP; Long YQ
Bioorg Med Chem Lett; 2016 Jun; 26(12):2900-2906. PubMed ID: 27133482
[TBL] [Abstract][Full Text] [Related]
7. Discovery of an irreversible HCV NS5B polymerase inhibitor.
Zeng Q; Nair AG; Rosenblum SB; Huang HC; Lesburg CA; Jiang Y; Selyutin O; Chan TY; Bennett F; Chen KX; Venkatraman S; Sannigrahi M; Velazquez F; Duca JS; Gavalas S; Huang Y; Pu H; Wang L; Pinto P; Vibulbhan B; Agrawal S; Ferrari E; Jiang CK; Li C; Hesk D; Gesell J; Sorota S; Shih NY; Njoroge FG; Kozlowski JA
Bioorg Med Chem Lett; 2013 Dec; 23(24):6585-7. PubMed ID: 24252545
[TBL] [Abstract][Full Text] [Related]
8. Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
McGowan D; Vendeville S; Lin TI; Tahri A; Hu L; Cummings MD; Amssoms K; Berke JM; Canard M; Cleiren E; Dehertogh P; Last S; Fransen E; Van Der Helm E; Van den Steen I; Vijgen L; Rouan MC; Fanning G; Nyanguile O; Van Emelen K; Simmen K; Raboisson P
Bioorg Med Chem Lett; 2012 Jul; 22(13):4431-6. PubMed ID: 22542193
[TBL] [Abstract][Full Text] [Related]
9. Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Stammers TA; Coulombe R; Duplessis M; Fazal G; Gagnon A; Garneau M; Goulet S; Jakalian A; LaPlante S; Rancourt J; Thavonekham B; Wernic D; Kukolj G; Beaulieu PL
Bioorg Med Chem Lett; 2013 Dec; 23(24):6879-85. PubMed ID: 24176401
[TBL] [Abstract][Full Text] [Related]
10. The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Alexandre FR; Badaroux E; Bilello JP; Bot S; Bouisset T; Brandt G; Cappelle S; Chapron C; Chaves D; Convard T; Counor C; Da Costa D; Dukhan D; Gay M; Gosselin G; Griffon JF; Gupta K; Hernandez-Santiago B; La Colla M; Lioure MP; Milhau J; Paparin JL; Peyronnet J; Parsy C; Pierra Rouvière C; Rahali H; Rahali R; Salanson A; Seifer M; Serra I; Standring D; Surleraux D; Dousson CB
Bioorg Med Chem Lett; 2017 Sep; 27(18):4323-4330. PubMed ID: 28835346
[TBL] [Abstract][Full Text] [Related]
11. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
Pacini B; Avolio S; Ercolani C; Koch U; Migliaccio G; Narjes F; Pacini L; Tomei L; Harper S
Bioorg Med Chem Lett; 2009 Nov; 19(21):6245-9. PubMed ID: 19800789
[TBL] [Abstract][Full Text] [Related]
12. Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
Canales E; Carlson JS; Appleby T; Fenaux M; Lee J; Tian Y; Tirunagari N; Wong M; Watkins WJ
Bioorg Med Chem Lett; 2012 Jul; 22(13):4288-92. PubMed ID: 22664130
[TBL] [Abstract][Full Text] [Related]
13. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Stammers TA; Coulombe R; Rancourt J; Thavonekham B; Fazal G; Goulet S; Jakalian A; Wernic D; Tsantrizos Y; Poupart MA; Bös M; McKercher G; Thauvette L; Kukolj G; Beaulieu PL
Bioorg Med Chem Lett; 2013 May; 23(9):2585-9. PubMed ID: 23545108
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Di Francesco ME; Avolio S; Pompei M; Pesci S; Monteagudo E; Pucci V; Giuliano C; Fiore F; Rowley M; Summa V
Bioorg Med Chem; 2012 Aug; 20(15):4801-11. PubMed ID: 22770556
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of
Wang G; Dyatkina N; Prhavc M; Williams C; Serebryany V; Hu Y; Huang Y; Wu X; Chen T; Huang W; Rajwanshi VK; Deval J; Fung A; Jin Z; Stoycheva A; Shaw K; Gupta K; Tam Y; Jekle A; Smith DB; Beigelman L
J Med Chem; 2020 Sep; 63(18):10380-10395. PubMed ID: 32816483
[TBL] [Abstract][Full Text] [Related]
16. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
Gopalsamy A; Lim K; Ciszewski G; Park K; Ellingboe JW; Bloom J; Insaf S; Upeslacis J; Mansour TS; Krishnamurthy G; Damarla M; Pyatski Y; Ho D; Howe AY; Orlowski M; Feld B; O'Connell J
J Med Chem; 2004 Dec; 47(26):6603-8. PubMed ID: 15588095
[TBL] [Abstract][Full Text] [Related]
17. Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Yang H; Hendricks RT; Arora N; Nitzan D; Yee C; Lucas MC; Yang Y; Fung A; Rajyaguru S; Harris SF; Leveque VJ; Hang JQ; Pogam SL; Reuter D; Tavares GA
Bioorg Med Chem Lett; 2010 Aug; 20(15):4614-9. PubMed ID: 20584604
[TBL] [Abstract][Full Text] [Related]
18. The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.
Chen YL; Tang J; Kesler MJ; Sham YY; Vince R; Geraghty RJ; Wang Z
Bioorg Med Chem; 2012 Jan; 20(1):467-79. PubMed ID: 22100256
[TBL] [Abstract][Full Text] [Related]
19. Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors.
Zhao C; Wang Y; Ma S
Eur J Med Chem; 2015 Sep; 102():188-214. PubMed ID: 26276434
[TBL] [Abstract][Full Text] [Related]
20. Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Nittoli T; Curran K; Insaf S; DiGrandi M; Orlowski M; Chopra R; Agarwal A; Howe AY; Prashad A; Floyd MB; Johnson B; Sutherland A; Wheless K; Feld B; O'Connell J; Mansour TS; Bloom J
J Med Chem; 2007 May; 50(9):2108-16. PubMed ID: 17402724
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]