BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 19470612)

  • 1. An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.
    Achilli F; Bros-Facer V; Williams HP; Banks GT; AlQatari M; Chia R; Tucci V; Groves M; Nickols CD; Seburn KL; Kendall R; Cader MZ; Talbot K; van Minnen J; Burgess RW; Brandner S; Martin JE; Koltzenburg M; Greensmith L; Nolan PM; Fisher EM
    Dis Model Mech; 2009; 2(7-8):359-73. PubMed ID: 19470612
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
    Banks GT; Bros-Facer V; Williams HP; Chia R; Achilli F; Bryson JB; Greensmith L; Fisher EM
    PLoS One; 2009 Jul; 4(7):e6218. PubMed ID: 19593442
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.
    Seburn KL; Nangle LA; Cox GA; Schimmel P; Burgess RW
    Neuron; 2006 Sep; 51(6):715-26. PubMed ID: 16982418
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
    Niehues S; Bussmann J; Steffes G; Erdmann I; Köhrer C; Sun L; Wagner M; Schäfer K; Wang G; Koerdt SN; Stum M; Jaiswal S; RajBhandary UL; Thomas U; Aberle H; Burgess RW; Yang XL; Dieterich D; Storkebaum E
    Nat Commun; 2015 Jul; 6():7520. PubMed ID: 26138142
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels.
    Motley WW; Seburn KL; Nawaz MH; Miers KE; Cheng J; Antonellis A; Green ED; Talbot K; Yang XL; Fischbeck KH; Burgess RW
    PLoS Genet; 2011 Dec; 7(12):e1002399. PubMed ID: 22144914
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
    Benoy V; Van Helleputte L; Prior R; d'Ydewalle C; Haeck W; Geens N; Scheveneels W; Schevenels B; Cader MZ; Talbot K; Kozikowski AP; Vanden Berghe P; Van Damme P; Robberecht W; Van Den Bosch L
    Brain; 2018 Mar; 141(3):673-687. PubMed ID: 29415205
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations.
    Griffin LB; Sakaguchi R; McGuigan D; Gonzalez MA; Searby C; Züchner S; Hou YM; Antonellis A
    Hum Mutat; 2014 Nov; 35(11):1363-71. PubMed ID: 25168514
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons.
    Antonellis A; Lee-Lin SQ; Wasterlain A; Leo P; Quezado M; Goldfarb LG; Myung K; Burgess S; Fischbeck KH; Green ED
    J Neurosci; 2006 Oct; 26(41):10397-406. PubMed ID: 17035524
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D).
    Seo AJ; Shin YH; Lee SJ; Kim D; Park BS; Kim S; Choi KH; Jeong NY; Park C; Jang JY; Huh Y; Jung J
    J Mol Histol; 2014 Apr; 45(2):121-8. PubMed ID: 23990368
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations.
    Stum M; McLaughlin HM; Kleinbrink EL; Miers KE; Ackerman SL; Seburn KL; Antonellis A; Burgess RW
    Mol Cell Neurosci; 2011 Feb; 46(2):432-43. PubMed ID: 21115117
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila.
    Ermanoska B; Motley WW; Leitão-Gonçalves R; Asselbergh B; Lee LH; De Rijk P; Sleegers K; Ooms T; Godenschwege TA; Timmerman V; Fischbeck KH; Jordanova A
    Neurobiol Dis; 2014 Aug; 68():180-9. PubMed ID: 24807208
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phenotypic spectrum of disorders associated with glycyl-tRNA synthetase mutations.
    Sivakumar K; Kyriakides T; Puls I; Nicholson GA; Funalot B; Antonellis A; Sambuughin N; Christodoulou K; Beggs JL; Zamba-Papanicolaou E; Ionasescu V; Dalakas MC; Green ED; Fischbeck KH; Goldfarb LG
    Brain; 2005 Oct; 128(Pt 10):2304-14. PubMed ID: 16014653
    [TBL] [Abstract][Full Text] [Related]  

  • 13. [A novel mutation in glycyl-tRNA synthetase caused Charcot-Marie-Tooth disease type 2D with facial and respiratory muscle involvement].
    Kawakami N; Komatsu K; Yamashita H; Uemura K; Oka N; Takashima H; Takahashi R
    Rinsho Shinkeigaku; 2014; 54(11):911-5. PubMed ID: 25420567
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Neuropathic pain model of peripheral neuropathies mediated by mutations of glycyl-tRNA synthetase.
    Lee SJ; Seo AJ; Park BS; Jo HW; Huh Y
    J Korean Med Sci; 2014 Aug; 29(8):1138-44. PubMed ID: 25120326
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice.
    Sleigh JN; Grice SJ; Burgess RW; Talbot K; Cader MZ
    Hum Mol Genet; 2014 May; 23(10):2639-50. PubMed ID: 24368416
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel mutation of the glycyl-tRNA synthetase (GARS) gene associated with Charcot-Marie-Tooth type 2D in a Chinese family.
    Sun A; Liu X; Zheng M; Sun Q; Huang Y; Fan D
    Neurol Res; 2015 Sep; 37(9):782-7. PubMed ID: 26000875
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by
    Sleigh JN; Dawes JM; West SJ; Wei N; Spaulding EL; Gómez-Martín A; Zhang Q; Burgess RW; Cader MZ; Talbot K; Yang XL; Bennett DL; Schiavo G
    Proc Natl Acad Sci U S A; 2017 Apr; 114(16):E3324-E3333. PubMed ID: 28351971
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dimerization is required for GARS-mediated neurotoxicity in dominant CMT disease.
    Malissovas N; Griffin LB; Antonellis A; Beis D
    Hum Mol Genet; 2016 Apr; 25(8):1528-42. PubMed ID: 27008886
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel mutation in the GARS gene in a Malian family with Charcot-Marie-Tooth disease.
    Yalcouyé A; Diallo SH; Coulibaly T; Cissé L; Diallo S; Samassékou O; Diarra S; Coulibaly D; Keita M; Guinto CO; Fischbeck K; Landouré G;
    Mol Genet Genomic Med; 2019 Jul; 7(7):e00782. PubMed ID: 31173493
    [TBL] [Abstract][Full Text] [Related]  

  • 20. SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
    Zhao Y; Xie L; Shen C; Qi Q; Qin Y; Xing J; Zhou D; Qi Y; Yan Z; Lin X; Dai R; Lin J; Yu W
    Aging Cell; 2021 Jun; 20(6):e13391. PubMed ID: 34053152
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.