BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

287 related articles for article (PubMed ID: 19470613)

  • 1. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.
    Ljungberg MC; Sunnen CN; Lugo JN; Anderson AE; D'Arcangelo G
    Dis Model Mech; 2009; 2(7-8):389-98. PubMed ID: 19470613
    [TBL] [Abstract][Full Text] [Related]  

  • 2. mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.
    Nguyen LH; Brewster AL; Clark ME; Regnier-Golanov A; Sunnen CN; Patil VV; D'Arcangelo G; Anderson AE
    Epilepsia; 2015 Apr; 56(4):636-46. PubMed ID: 25752454
    [TBL] [Abstract][Full Text] [Related]  

  • 3. mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia.
    Nguyen LH; Mahadeo T; Bordey A
    J Neurosci; 2019 Apr; 39(14):2762-2773. PubMed ID: 30700531
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity.
    Zhang L; Huang T; Teaw S; Bordey A
    Epilepsia; 2019 Jun; 60(6):1255-1265. PubMed ID: 31125447
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.
    Matsushita Y; Sakai Y; Shimmura M; Shigeto H; Nishio M; Akamine S; Sanefuji M; Ishizaki Y; Torisu H; Nakabeppu Y; Suzuki A; Takada H; Hara T
    Sci Rep; 2016 Mar; 6():22991. PubMed ID: 26961412
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.
    Yuskaitis CJ; Jones BM; Wolfson RL; Super CE; Dhamne SC; Rotenberg A; Sabatini DM; Sahin M; Poduri A
    Neurobiol Dis; 2018 Mar; 111():91-101. PubMed ID: 29274432
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.
    Hsieh LS; Wen JH; Claycomb K; Huang Y; Harrsch FA; Naegele JR; Hyder F; Buchanan GF; Bordey A
    Nat Commun; 2016 Jun; 7():11753. PubMed ID: 27249187
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.
    Nikolaeva I; Kazdoba TM; Crowell B; D'Arcangelo G
    Neuroscience; 2017 Jun; 354():196-207. PubMed ID: 28457820
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia.
    Lim JS; Gopalappa R; Kim SH; Ramakrishna S; Lee M; Kim WI; Kim J; Park SM; Lee J; Oh JH; Kim HD; Park CH; Lee JS; Kim S; Kim DS; Han JM; Kang HC; Kim HH; Lee JH
    Am J Hum Genet; 2017 Mar; 100(3):454-472. PubMed ID: 28215400
    [TBL] [Abstract][Full Text] [Related]  

  • 10. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy.
    Nguyen LH; Anderson AE
    Sci Rep; 2018 Feb; 8(1):3568. PubMed ID: 29476105
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold.
    Iffland PH; Everett ME; Cobb-Pitstick KM; Bowser LE; Barnes AE; Babus JK; Romanowski AJ; Baybis M; Elziny S; Puffenberger EG; Gonzaga-Jauregui C; Poulopoulos A; Carson VJ; Crino PB
    Brain; 2022 Nov; 145(11):3872-3885. PubMed ID: 35136953
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting the Mammalian Target of Rapamycin for Epileptic Encephalopathies and Malformations of Cortical Development.
    Jeong A; Wong M
    J Child Neurol; 2018 Jan; 33(1):55-63. PubMed ID: 29246093
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
    Getz SA; DeSpenza T; Li M; Luikart BW
    Neurobiol Dis; 2016 Sep; 93():12-20. PubMed ID: 26992888
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.
    Sunnen CN; Brewster AL; Lugo JN; Vanegas F; Turcios E; Mukhi S; Parghi D; D'Arcangelo G; Anderson AE
    Epilepsia; 2011 Nov; 52(11):2065-75. PubMed ID: 21973019
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rapamycin improves social and stereotypic behavior abnormalities induced by pre-mitotic neuronal subset specific Pten deletion.
    Narvaiz DA; Nolan SO; Smith GD; Holley AJ; Reynolds CD; Blandin KJ; Nguyen PH; Tran DLK; Lugo JN
    Genes Brain Behav; 2023 Aug; 22(4):e12854. PubMed ID: 37376966
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.
    Zeng LH; Rensing NR; Wong M
    J Neurosci; 2009 May; 29(21):6964-72. PubMed ID: 19474323
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Focal brain malformations: seizures, signaling, sequencing.
    Crino PB
    Epilepsia; 2009 Oct; 50 Suppl 9():3-8. PubMed ID: 19761448
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.
    Park SM; Lim JS; Ramakrishina S; Kim SH; Kim WK; Lee J; Kang HC; Reiter JF; Kim DS; Kim HH; Lee JH
    Neuron; 2018 Jul; 99(1):83-97.e7. PubMed ID: 29937275
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia.
    Jansen LA; Mirzaa GM; Ishak GE; O'Roak BJ; Hiatt JB; Roden WH; Gunter SA; Christian SL; Collins S; Adams C; Rivière JB; St-Onge J; Ojemann JG; Shendure J; Hevner RF; Dobyns WB
    Brain; 2015 Jun; 138(Pt 6):1613-28. PubMed ID: 25722288
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.
    Mirzaa GM; Campbell CD; Solovieff N; Goold C; Jansen LA; Menon S; Timms AE; Conti V; Biag JD; Adams C; Boyle EA; Collins S; Ishak G; Poliachik S; Girisha KM; Yeung KS; Chung BHY; Rahikkala E; Gunter SA; McDaniel SS; Macmurdo CF; Bernstein JA; Martin B; Leary R; Mahan S; Liu S; Weaver M; Doerschner M; Jhangiani S; Muzny DM; Boerwinkle E; Gibbs RA; Lupski JR; Shendure J; Saneto RP; Novotny EJ; Wilson CJ; Sellers WR; Morrissey M; Hevner RF; Ojemann JG; Guerrini R; Murphy LO; Winckler W; Dobyns WB
    JAMA Neurol; 2016 Jul; 73(7):836-845. PubMed ID: 27159400
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.