297 related articles for article (PubMed ID: 19474450)
1. A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction.
Perumbeti A; Higashimoto T; Urbinati F; Franco R; Meiselman HJ; Witte D; Malik P
Blood; 2009 Aug; 114(6):1174-85. PubMed ID: 19474450
[TBL] [Abstract][Full Text] [Related]
2. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
Pestina TI; Hargrove PW; Jay D; Gray JT; Boyd KM; Persons DA
Mol Ther; 2009 Feb; 17(2):245-52. PubMed ID: 19050697
[TBL] [Abstract][Full Text] [Related]
3. Post-Transcriptional Genetic Silencing of
Esrick EB; Lehmann LE; Biffi A; Achebe M; Brendel C; Ciuculescu MF; Daley H; MacKinnon B; Morris E; Federico A; Abriss D; Boardman K; Khelladi R; Shaw K; Negre H; Negre O; Nikiforow S; Ritz J; Pai SY; London WB; Dansereau C; Heeney MM; Armant M; Manis JP; Williams DA
N Engl J Med; 2021 Jan; 384(3):205-215. PubMed ID: 33283990
[TBL] [Abstract][Full Text] [Related]
4. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.
Rivers A; Vaitkus K; Jagadeeswaran R; Ruiz MA; Ibanez V; Ciceri F; Cavalcanti F; Molokie RE; Saunthararajah Y; Engel JD; DeSimone J; Lavelle D
Exp Hematol; 2018 Nov; 67():60-64.e2. PubMed ID: 30125603
[TBL] [Abstract][Full Text] [Related]
5. Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells.
Urbinati F; Hargrove PW; Geiger S; Romero Z; Wherley J; Kaufman ML; Hollis RP; Chambers CB; Persons DA; Kohn DB; Wilber A
Exp Hematol; 2015 May; 43(5):346-351. PubMed ID: 25681747
[TBL] [Abstract][Full Text] [Related]
6. The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34
Drakopoulou E; Georgomanoli M; Lederer CW; Panetsos F; Kleanthous M; Voskaridou E; Valakos D; Papanikolaou E; Anagnou NP
Viruses; 2022 Dec; 14(12):. PubMed ID: 36560719
[TBL] [Abstract][Full Text] [Related]
7. Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia.
Zhao HF; Abraham A; Kim YS; Wang YD; Pestina T; Zhan J; Humphries K; Nienhuis AW; Persons DA
Mol Ther; 2017 Mar; 25(3):593-605. PubMed ID: 28190779
[TBL] [Abstract][Full Text] [Related]
8. The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number.
Persons DA; Hargrove PW; Allay ER; Hanawa H; Nienhuis AW
Blood; 2003 Mar; 101(6):2175-83. PubMed ID: 12411297
[TBL] [Abstract][Full Text] [Related]
9. Gene Therapy for Sickle Cell Disease: A Lentiviral Vector Comparison Study.
Urbinati F; Campo Fernandez B; Masiuk KE; Poletti V; Hollis RP; Koziol C; Kaufman ML; Brown D; Mavilio F; Kohn DB
Hum Gene Ther; 2018 Oct; 29(10):1153-1166. PubMed ID: 30198339
[TBL] [Abstract][Full Text] [Related]
10. Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
Zhao H; Pestina TI; Nasimuzzaman M; Mehta P; Hargrove PW; Persons DA
Blood; 2009 Jun; 113(23):5747-56. PubMed ID: 19365082
[TBL] [Abstract][Full Text] [Related]
11. Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurations.
Woodard KJ; Doerfler PA; Mayberry KD; Sharma A; Levine R; Yen J; Valentine V; Palmer LE; Valentine M; Weiss MJ
Dis Model Mech; 2022 Jun; 15(6):. PubMed ID: 35793591
[TBL] [Abstract][Full Text] [Related]
12. Tenofovir disoproxil fumarate induces fetal hemoglobin production in K562 cells and β-YAC transgenic mice: A therapeutic approach for γ-globin induction.
Khan F; Ali H; Musharraf SG
Exp Cell Res; 2020 Sep; 394(2):112168. PubMed ID: 32653411
[TBL] [Abstract][Full Text] [Related]
13. Rheological properties of sickle erythrocytes in patients with sickle-cell anemia: The effect of hydroxyurea, fetal hemoglobin, and α-thalassemia.
Ballas SK; Connes P;
Eur J Haematol; 2018 Dec; 101(6):798-803. PubMed ID: 30204261
[TBL] [Abstract][Full Text] [Related]
14. Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells.
Levasseur DN; Ryan TM; Pawlik KM; Townes TM
Blood; 2003 Dec; 102(13):4312-9. PubMed ID: 12933581
[TBL] [Abstract][Full Text] [Related]
15. Correction of sickle cell disease by homologous recombination in embryonic stem cells.
Wu LC; Sun CW; Ryan TM; Pawlik KM; Ren J; Townes TM
Blood; 2006 Aug; 108(4):1183-8. PubMed ID: 16638928
[TBL] [Abstract][Full Text] [Related]
16. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.
Xu J; Peng C; Sankaran VG; Shao Z; Esrick EB; Chong BG; Ippolito GC; Fujiwara Y; Ebert BL; Tucker PW; Orkin SH
Science; 2011 Nov; 334(6058):993-6. PubMed ID: 21998251
[TBL] [Abstract][Full Text] [Related]
17. Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.
Pestina TI; Hargrove PW; Zhao H; Mead PE; Smeltzer MP; Weiss MJ; Wilber A; Persons DA
Mol Ther Methods Clin Dev; 2015; 2():15045. PubMed ID: 26665131
[TBL] [Abstract][Full Text] [Related]
18. Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice.
Wilkinson AC; Dever DP; Baik R; Camarena J; Hsu I; Charlesworth CT; Morita C; Nakauchi H; Porteus MH
Nat Commun; 2021 Jan; 12(1):686. PubMed ID: 33514718
[TBL] [Abstract][Full Text] [Related]
19. A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.
Wilber A; Tschulena U; Hargrove PW; Kim YS; Persons DA; Barbas CF; Nienhuis AW
Blood; 2010 Apr; 115(15):3033-41. PubMed ID: 20190190
[TBL] [Abstract][Full Text] [Related]
20. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
Krishnamoorthy S; Pace B; Gupta D; Sturtevant S; Li B; Makala L; Brittain J; Moore N; Vieira BF; Thullen T; Stone I; Li H; Hobbs WE; Light DR
JCI Insight; 2017 Oct; 2(20):. PubMed ID: 29046485
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
