BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 19479253)

  • 1. Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
    Nathwani SM; Butler S; Meegan MJ; Campiani G; Lawler M; Williams DC; Zisterer DM
    Cancer Chemother Pharmacol; 2010 Jan; 65(2):289-300. PubMed ID: 19479253
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
    Nathwani SM; Butler S; Fayne D; McGovern NN; Sarkadi B; Meegan MJ; Lloyd DG; Campiani G; Lawler M; Williams DC; Zisterer DM
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):585-96. PubMed ID: 20020128
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
    Mulligan JM; Greene LM; Cloonan S; Mc Gee MM; Onnis V; Campiani G; Fattorusso C; Lawler M; Williams DC; Zisterer DM
    Mol Pharmacol; 2006 Jul; 70(1):60-70. PubMed ID: 16571652
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM; Maginn EN; Greene LM; McGuckin S; Hayat A; Browne PV; Butini S; Campiani G; Catherwood MA; Vandenberghe E; Williams DC; Zisterer DM; Lawler M
    Cancer Res; 2009 Nov; 69(21):8366-75. PubMed ID: 19826055
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
    Mc Gee MM; Campiani G; Ramunno A; Fattorusso C; Nacci V; Lawler M; Williams DC; Zisterer DM
    J Pharmacol Exp Ther; 2001 Jan; 296(1):31-40. PubMed ID: 11123359
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.
    Zisterer DM; Campiani G; Nacci V; Williams DC
    J Pharmacol Exp Ther; 2000 Apr; 293(1):48-59. PubMed ID: 10734152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
    Nathwani SM; Cloonan SM; Stronach M; Campiani G; Lawler M; Williams DC; Zisterer DM
    Oncol Rep; 2010 Dec; 24(6):1499-507. PubMed ID: 21042745
    [TBL] [Abstract][Full Text] [Related]  

  • 8. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
    Greene LM; Kelly L; Onnis V; Campiani G; Lawler M; Williams DC; Zisterer DM
    J Pharmacol Exp Ther; 2007 Apr; 321(1):288-97. PubMed ID: 17202400
    [TBL] [Abstract][Full Text] [Related]  

  • 9. BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.
    Greene LM; Campiani G; Lawler M; Williams DC; Zisterer DM
    Mol Pharmacol; 2008 Feb; 73(2):419-30. PubMed ID: 17991869
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.
    Lysaght J; Verma NK; Maginn EN; Ryan JM; Campiani G; Zisterer DM; Williams DC; Browne PV; Lawler MP; McElligott AM
    Int J Oncol; 2013 Jan; 42(1):239-46. PubMed ID: 23135704
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
    Verma NK; Dempsey E; Conroy J; Olwell P; Mcelligott AM; Davies AM; Kelleher D; Butini S; Campiani G; Williams DC; Zisterer DM; Lawler M; Volkov Y
    J Mol Med (Berl); 2008 Apr; 86(4):457-69. PubMed ID: 18270678
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents.
    Zisterer DM; McGee MM; Campiani G; Ramunno A; Fattorusso C; Nacci V; Lawler M; Williams DC
    Biochem Soc Trans; 2001 Nov; 29(Pt 6):704-6. PubMed ID: 11709059
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
    Bright SA; Campiani G; Deininger MW; Lawler M; Williams DC; Zisterer DM
    Biochem Pharmacol; 2010 Jul; 80(1):31-8. PubMed ID: 20206141
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
    Greene LM; Fleeton M; Mulligan J; Gowda C; Sheahan BJ; Atkins GJ; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
    Oncol Rep; 2005 Nov; 14(5):1357-63. PubMed ID: 16211309
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
    Lennon JC; Bright SA; Carroll E; Butini S; Campiani G; O'Meara A; Williams DC; Zisterer DM
    Biochem Pharmacol; 2014 Feb; 87(4):611-24. PubMed ID: 24406249
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
    Mc Gee MM; Greene LM; Ledwidge S; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1084-95. PubMed ID: 15143129
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
    Bright SA; Greene LM; Greene TF; Campiani G; Butini S; Brindisi M; Lawler M; Meegan MJ; Williams DC; Zisterer DM
    Biochem Pharmacol; 2009 Feb; 77(3):310-21. PubMed ID: 19014913
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
    Staedler D; Chapuis-Bernasconi C; Dehmlow H; Fischer H; Juillerat-Jeanneret L; Aebi JD
    J Med Chem; 2012 Jun; 55(11):4990-5002. PubMed ID: 22533316
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.
    Shanab K; Schirmer E; Knafl H; Wulz E; Holzer W; Spreitzer H; Schmidt P; Aicher B; Müller G; Günther E
    Bioorg Med Chem Lett; 2010 Jul; 20(13):3950-2. PubMed ID: 20537894
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6.
    Mc Gee MM; Hyland E; Campiani G; Ramunno A; Nacci V; Zisterer DM
    FEBS Lett; 2002 Mar; 515(1-3):66-70. PubMed ID: 11943196
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.