BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 19483413)

  • 21. Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists.
    Gim HJ; Li H; Lee E; Ryu JH; Jeon R
    Bioorg Med Chem Lett; 2013 Jan; 23(2):513-7. PubMed ID: 23265886
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Advances and Challenges in Drug Design of PPARδ Ligands.
    Maltarollo VG; Kronenberger T; Windshugel B; Wrenger C; Trossini GHG; Honorio KM
    Curr Drug Targets; 2018; 19(2):144-154. PubMed ID: 28413978
    [TBL] [Abstract][Full Text] [Related]  

  • 23. A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes.
    Sakamoto J; Kimura H; Moriyama S; Imoto H; Momose Y; Odaka H; Sawada H
    Eur J Pharmacol; 2004 Jul; 495(1):17-26. PubMed ID: 15219816
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure.
    Kato T; Fukao K; Ohara T; Naya N; Tokuyama R; Muto S; Fukasawa H; Itai A; Matsumura KI
    J Med Chem; 2023 Aug; 66(16):11428-11446. PubMed ID: 37552807
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors.
    Miyachi H
    Int J Mol Sci; 2021 Aug; 22(17):. PubMed ID: 34502131
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
    Feng Z; Xiang J; Liu H; Li J; Xu X; Sun G; Zheng R; Zhang S; Liu J; Yang S; Xu Q; Wen X; Yuan H; Sun H; Dai L
    J Med Chem; 2022 Feb; 65(3):2571-2592. PubMed ID: 35060744
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.
    Weigand S; Bischoff H; Dittrich-Wengenroth E; Heckroth H; Lang D; Vaupel A; Woltering M
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4619-23. PubMed ID: 16115765
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
    Shen L; Zhang Y; Wang A; Sieber-McMaster E; Chen X; Pelton P; Xu JZ; Yang M; Zhu P; Zhou L; Reuman M; Hu Z; Russell R; Gibbs AC; Ross H; Demarest K; Murray WV; Kuo GH
    Bioorg Med Chem; 2008 Mar; 16(6):3321-41. PubMed ID: 18155554
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands.
    Araya Y; Kasuga J; Toyota K; Hirakawa Y; Oyama T; Makishima M; Morikawa K; Hashimoto Y; Miyachi H
    Chem Pharm Bull (Tokyo); 2008 Sep; 56(9):1357-9. PubMed ID: 18758120
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.
    Aleshin S; Grabeklis S; Hanck T; Sergeeva M; Reiser G
    Mol Pharmacol; 2009 Aug; 76(2):414-24. PubMed ID: 19483106
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
    Zhou Z; Cai Z; Zhang C; Yang B; Chen L; He Y; Zhang L; Li Z
    Bioorg Med Chem; 2022 Feb; 56():116615. PubMed ID: 35051813
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.
    Kim DS; Lee J; Londhe AM; Kadayat TM; Joo J; Hwang H; Kim KH; Pae AN; Chin J; Cho SJ; Kang H
    Bioorg Med Chem; 2018 Aug; 26(15):4382-4389. PubMed ID: 30054191
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.
    Kasuga J; Ishikawa M; Yonehara M; Makishima M; Hashimoto Y; Miyachi H
    Bioorg Med Chem; 2010 Oct; 18(20):7164-73. PubMed ID: 20843696
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Ligand- and structure-based drug design strategies and PPARδ/α selectivity.
    Maltarollo VG; Honório KM
    Chem Biol Drug Des; 2012 Oct; 80(4):533-44. PubMed ID: 22672760
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM.
    Ren Q; Deng L; Zhou Z; Wang X; Hu L; Xie R; Li Z
    Bioorg Chem; 2020 Aug; 101():103963. PubMed ID: 32480174
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative.
    Oyama T; Takiguchi K; Miyachi H
    Acta Crystallogr F Struct Biol Commun; 2022 Feb; 78(Pt 2):81-87. PubMed ID: 35102897
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta.
    Shen L; Zhang Y; Wang A; Sieber-McMaster E; Chen X; Pelton P; Xu JZ; Yang M; Zhu P; Zhou L; Reuman M; Hu Z; Russell R; Gibbs AC; Ross H; Demarest K; Murray WV; Kuo GH
    J Med Chem; 2007 Aug; 50(16):3954-63. PubMed ID: 17608467
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.
    Kato T; Ohara T; Suzuki N; Muto S; Tokuyama R; Mizutani M; Fukasawa H; Matsumura KI; Itai A
    Bioorg Med Chem Lett; 2022 Mar; 59():128567. PubMed ID: 35063634
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.
    Xu Y; Etgen GJ; Broderick CL; Canada E; Gonzalez I; Lamar J; Montrose-Rafizadeh C; Oldham BA; Osborne JJ; Xie C; Shi Q; Winneroski LL; York J; Yumibe N; Zink R; Mantlo N
    J Med Chem; 2006 Sep; 49(19):5649-52. PubMed ID: 16970391
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
    Evans KA; Shearer BG; Wisnoski DD; Shi D; Sparks SM; Sternbach DD; Winegar DA; Billin AN; Britt C; Way JM; Epperly AH; Leesnitzer LM; Merrihew RV; Xu RX; Lambert MH; Jin J
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2345-50. PubMed ID: 21414782
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.