BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 19487444)

  • 1. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity.
    Karlowsky JA; Kaplan N; Hafkin B; Hoban DJ; Zhanel GG
    Antimicrob Agents Chemother; 2009 Aug; 53(8):3544-8. PubMed ID: 19487444
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis.
    Karlowsky JA; Laing NM; Baudry T; Kaplan N; Vaughan D; Hoban DJ; Zhanel GG
    Antimicrob Agents Chemother; 2007 Apr; 51(4):1580-1. PubMed ID: 17220418
    [No Abstract]   [Full Text] [Related]  

  • 3. Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor.
    Kaplan N; Albert M; Awrey D; Bardouniotis E; Berman J; Clarke T; Dorsey M; Hafkin B; Ramnauth J; Romanov V; Schmid MB; Thalakada R; Yethon J; Pauls HW
    Antimicrob Agents Chemother; 2012 Nov; 56(11):5865-74. PubMed ID: 22948878
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).
    Yao J; Maxwell JB; Rock CO
    J Biol Chem; 2013 Dec; 288(51):36261-71. PubMed ID: 24189061
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics.
    Tsuji BT; Harigaya Y; Lesse AJ; Forrest A; Ngo D
    J Chemother; 2013 Feb; 25(1):32-5. PubMed ID: 23433442
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics.
    Kaplan N; Awrey D; Bardouniotis E; Berman J; Yethon J; Pauls HW; Hafkin B
    J Chemother; 2013 Feb; 25(1):18-25. PubMed ID: 23433440
    [TBL] [Abstract][Full Text] [Related]  

  • 7. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.
    Rao KN; Lakshminarasimhan A; Joseph S; Lekshmi SU; Lau MS; Takhi M; Sreenivas K; Nathan S; Yusof R; Abd Rahman N; Ramachandra M; Antony T; Subramanya H
    Protein Sci; 2015 May; 24(5):832-40. PubMed ID: 25644789
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a novel and potent class of FabI-directed antibacterial agents.
    Payne DJ; Miller WH; Berry V; Brosky J; Burgess WJ; Chen E; DeWolf WE; Fosberry AP; Greenwood R; Head MS; Heerding DA; Janson CA; Jaworski DD; Keller PM; Manley PJ; Moore TD; Newlander KA; Pearson S; Polizzi BJ; Qiu X; Rittenhouse SF; Slater-Radosti C; Salyers KL; Seefeld MA; Smyth MG; Takata DT; Uzinskas IN; Vaidya K; Wallis NG; Winram SB; Yuan CC; Huffman WF
    Antimicrob Agents Chemother; 2002 Oct; 46(10):3118-24. PubMed ID: 12234833
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Efficacy and Safety of AFN-1252, the First Staphylococcus-Specific Antibacterial Agent, in the Treatment of Acute Bacterial Skin and Skin Structure Infections, Including Those in Patients with Significant Comorbidities.
    Hafkin B; Kaplan N; Murphy B
    Antimicrob Agents Chemother; 2015 Dec; 60(3):1695-701. PubMed ID: 26711777
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model.
    Banevicius MA; Kaplan N; Hafkin B; Nicolau DP
    J Chemother; 2013 Feb; 25(1):26-31. PubMed ID: 23433441
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CG400462, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.
    Park HS; Yoon YM; Jung SJ; Yun IN; Kim CM; Kim JM; Kwak JH
    Int J Antimicrob Agents; 2007 Nov; 30(5):446-51. PubMed ID: 17723291
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252.
    Parsons JB; Kukula M; Jackson P; Pulse M; Simecka JW; Valtierra D; Weiss WJ; Kaplan N; Rock CO
    Antimicrob Agents Chemother; 2013 May; 57(5):2182-90. PubMed ID: 23459481
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba.
    Kim YJ; Sohn MJ; Kim WG
    Biol Pharm Bull; 2012; 35(5):791-5. PubMed ID: 22687419
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound.
    Escaich S; Prouvensier L; Saccomani M; Durant L; Oxoby M; Gerusz V; Moreau F; Vongsouthi V; Maher K; Morrissey I; Soulama-Mouze C
    Antimicrob Agents Chemother; 2011 Oct; 55(10):4692-7. PubMed ID: 21825292
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611.
    Kwon YJ; Fang Y; Xu GH; Kim WG
    Biol Pharm Bull; 2009 Dec; 32(12):2061-4. PubMed ID: 19952429
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
    Yum JH; Kim CK; Yong D; Lee K; Chong Y; Kim CM; Kim JM; Ro S; Cho JM
    Antimicrob Agents Chemother; 2007 Jul; 51(7):2591-3. PubMed ID: 17420210
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bone and Joint Tissue Penetration of the
    Menetrey A; Janin A; Pullman J; Overcash JS; Haouala A; Leylavergne F; Turbe L; Wittke F; Nicolas-Métral V
    Antimicrob Agents Chemother; 2019 Mar; 63(3):. PubMed ID: 30559136
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.
    Kitagawa H; Ozawa T; Takahata S; Iida M; Saito J; Yamada M
    J Med Chem; 2007 Sep; 50(19):4710-20. PubMed ID: 17713898
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of 4-Pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus.
    Takahata S; Iida M; Yoshida T; Kumura K; Kitagawa H; Hoshiko S
    J Antibiot (Tokyo); 2007 Feb; 60(2):123-8. PubMed ID: 17420562
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A FASII Inhibitor Prevents Staphylococcal Evasion of Daptomycin by Inhibiting Phospholipid Decoy Production.
    Pee CJE; Pader V; Ledger EVK; Edwards AM
    Antimicrob Agents Chemother; 2019 Apr; 63(4):. PubMed ID: 30718253
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.