169 related articles for article (PubMed ID: 19488402)
1. IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
Khoshnan A; Ko J; Tescu S; Brundin P; Patterson PH
PLoS One; 2009 Jun; 4(6):e5768. PubMed ID: 19488402
[TBL] [Abstract][Full Text] [Related]
2. The role of IκB kinase complex in the neurobiology of Huntington's disease.
Khoshnan A; Patterson PH
Neurobiol Dis; 2011 Aug; 43(2):305-11. PubMed ID: 21554955
[TBL] [Abstract][Full Text] [Related]
3. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
Kim YJ; Yi Y; Sapp E; Wang Y; Cuiffo B; Kegel KB; Qin ZH; Aronin N; DiFiglia M
Proc Natl Acad Sci U S A; 2001 Oct; 98(22):12784-9. PubMed ID: 11675509
[TBL] [Abstract][Full Text] [Related]
4. IKKβ slows Huntington's disease progression in R6/1 mice.
Ochaba J; Fote G; Kachemov M; Thein S; Yeung SY; Lau AL; Hernandez S; Lim RG; Casale M; Neel MJ; Monuki ES; Reidling J; Housman DE; Thompson LM; Steffan JS
Proc Natl Acad Sci U S A; 2019 May; 116(22):10952-10961. PubMed ID: 31088970
[TBL] [Abstract][Full Text] [Related]
5. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
[TBL] [Abstract][Full Text] [Related]
6. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL; Ellerby LM; Gutekunst CA; Rogers D; Warby S; Graham RK; Loubser O; van Raamsdonk J; Singaraja R; Yang YZ; Gafni J; Bredesen D; Hersch SM; Leavitt BR; Roy S; Nicholson DW; Hayden MR
J Neurosci; 2002 Sep; 22(18):7862-72. PubMed ID: 12223539
[TBL] [Abstract][Full Text] [Related]
7. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Chen LW; Chen PH; Chang WJ; Wang JS; Karin M; Hsu CM
Crit Care Med; 2007 May; 35(5):1332-40. PubMed ID: 17414734
[TBL] [Abstract][Full Text] [Related]
8. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
[TBL] [Abstract][Full Text] [Related]
9. Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.
Khoshnan A; Ko J; Watkin EE; Paige LA; Reinhart PH; Patterson PH
J Neurosci; 2004 Sep; 24(37):7999-8008. PubMed ID: 15371500
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
Gafni J; Hermel E; Young JE; Wellington CL; Hayden MR; Ellerby LM
J Biol Chem; 2004 May; 279(19):20211-20. PubMed ID: 14981075
[TBL] [Abstract][Full Text] [Related]
11. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson LM; Aiken CT; Kaltenbach LS; Agrawal N; Illes K; Khoshnan A; Martinez-Vincente M; Arrasate M; O'Rourke JG; Khashwji H; Lukacsovich T; Zhu YZ; Lau AL; Massey A; Hayden MR; Zeitlin SO; Finkbeiner S; Green KN; LaFerla FM; Bates G; Huang L; Patterson PH; Lo DC; Cuervo AM; Marsh JL; Steffan JS
J Cell Biol; 2009 Dec; 187(7):1083-99. PubMed ID: 20026656
[TBL] [Abstract][Full Text] [Related]
12. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
Miller JP; Holcomb J; Al-Ramahi I; de Haro M; Gafni J; Zhang N; Kim E; Sanhueza M; Torcassi C; Kwak S; Botas J; Hughes RE; Ellerby LM
Neuron; 2010 Jul; 67(2):199-212. PubMed ID: 20670829
[TBL] [Abstract][Full Text] [Related]
13. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
Zhang H; Li Q; Graham RK; Slow E; Hayden MR; Bezprozvanny I
Neurobiol Dis; 2008 Jul; 31(1):80-8. PubMed ID: 18502655
[TBL] [Abstract][Full Text] [Related]
14. Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?
Sawa A
J Mol Med (Berl); 2001 Jul; 79(7):375-81. PubMed ID: 11466559
[TBL] [Abstract][Full Text] [Related]
15. Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species.
May MJ; Madge LA
J Biol Chem; 2007 Jun; 282(22):16105-16. PubMed ID: 17430892
[TBL] [Abstract][Full Text] [Related]
16. Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.
Garcia M; Charvin D; Caboche J
Neuroscience; 2004; 127(4):859-70. PubMed ID: 15312898
[TBL] [Abstract][Full Text] [Related]
17. Regulation and function of IKK and IKK-related kinases.
Häcker H; Karin M
Sci STKE; 2006 Oct; 2006(357):re13. PubMed ID: 17047224
[TBL] [Abstract][Full Text] [Related]
18. DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates.
Illuzzi J; Yerkes S; Parekh-Olmedo H; Kmiec EB
J Neurosci Res; 2009 Feb; 87(3):733-47. PubMed ID: 18831068
[TBL] [Abstract][Full Text] [Related]
19. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Tanaka Y; Igarashi S; Nakamura M; Gafni J; Torcassi C; Schilling G; Crippen D; Wood JD; Sawa A; Jenkins NA; Copeland NG; Borchelt DR; Ross CA; Ellerby LM
Neurobiol Dis; 2006 Feb; 21(2):381-91. PubMed ID: 16150600
[TBL] [Abstract][Full Text] [Related]
20. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
Wellington CL; Singaraja R; Ellerby L; Savill J; Roy S; Leavitt B; Cattaneo E; Hackam A; Sharp A; Thornberry N; Nicholson DW; Bredesen DE; Hayden MR
J Biol Chem; 2000 Jun; 275(26):19831-8. PubMed ID: 10770929
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
