465 related articles for article (PubMed ID: 19489739)
1. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
Eggler AL; Small E; Hannink M; Mesecar AD
Biochem J; 2009 Jul; 422(1):171-80. PubMed ID: 19489739
[TBL] [Abstract][Full Text] [Related]
2. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
Kaspar JW; Niture SK; Jaiswal AK
J Cell Sci; 2012 Feb; 125(Pt 4):1027-38. PubMed ID: 22448038
[TBL] [Abstract][Full Text] [Related]
3. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.
He X; Ma Q
Mol Pharmacol; 2009 Dec; 76(6):1265-78. PubMed ID: 19786557
[TBL] [Abstract][Full Text] [Related]
4. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
Furukawa M; Xiong Y
Mol Cell Biol; 2005 Jan; 25(1):162-71. PubMed ID: 15601839
[TBL] [Abstract][Full Text] [Related]
5. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Baird L; Dinkova-Kostova AT
Biochem Biophys Res Commun; 2013 Mar; 433(1):58-65. PubMed ID: 23454126
[TBL] [Abstract][Full Text] [Related]
6. Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Sekhar KR; Rachakonda G; Freeman ML
Toxicol Appl Pharmacol; 2010 Apr; 244(1):21-6. PubMed ID: 19560482
[TBL] [Abstract][Full Text] [Related]
7. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Zhang DD; Lo SC; Cross JV; Templeton DJ; Hannink M
Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
[TBL] [Abstract][Full Text] [Related]
8. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
He X; Chen MG; Lin GX; Ma Q
J Biol Chem; 2006 Aug; 281(33):23620-31. PubMed ID: 16785233
[TBL] [Abstract][Full Text] [Related]
9. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound.
Ohnuma T; Nakayama S; Anan E; Nishiyama T; Ogura K; Hiratsuka A
Toxicol Appl Pharmacol; 2010 Apr; 244(1):27-36. PubMed ID: 20026152
[TBL] [Abstract][Full Text] [Related]
10. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Lau A; Wang XJ; Zhao F; Villeneuve NF; Wu T; Jiang T; Sun Z; White E; Zhang DD
Mol Cell Biol; 2010 Jul; 30(13):3275-85. PubMed ID: 20421418
[TBL] [Abstract][Full Text] [Related]
11. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
Shibata T; Ohta T; Tong KI; Kokubu A; Odogawa R; Tsuta K; Asamura H; Yamamoto M; Hirohashi S
Proc Natl Acad Sci U S A; 2008 Sep; 105(36):13568-73. PubMed ID: 18757741
[TBL] [Abstract][Full Text] [Related]
12. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
Sun Z; Zhang S; Chan JY; Zhang DD
Mol Cell Biol; 2007 Sep; 27(18):6334-49. PubMed ID: 17636022
[TBL] [Abstract][Full Text] [Related]
13. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
[TBL] [Abstract][Full Text] [Related]
14. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Hayes JD; McMahon M; Chowdhry S; Dinkova-Kostova AT
Antioxid Redox Signal; 2010 Dec; 13(11):1713-48. PubMed ID: 20446772
[TBL] [Abstract][Full Text] [Related]
15. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
Zhang DD; Lo SC; Sun Z; Habib GM; Lieberman MW; Hannink M
J Biol Chem; 2005 Aug; 280(34):30091-9. PubMed ID: 15983046
[TBL] [Abstract][Full Text] [Related]
16. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
He X; Ma Q
J Pharmacol Exp Ther; 2010 Jan; 332(1):66-75. PubMed ID: 19808700
[TBL] [Abstract][Full Text] [Related]
17. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
Villeneuve NF; Lau A; Zhang DD
Antioxid Redox Signal; 2010 Dec; 13(11):1699-712. PubMed ID: 20486766
[TBL] [Abstract][Full Text] [Related]
18. Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Su C; Zhang P; Song X; Shi Q; Fu J; Xia X; Bai H; Hu L; Xu D; Song E; Song Y
Chem Res Toxicol; 2015 Apr; 28(4):765-74. PubMed ID: 25742418
[TBL] [Abstract][Full Text] [Related]
19. A small-molecule inducer of the antioxidant response element.
Hur W; Sun Z; Jiang T; Mason DE; Peters EC; Zhang DD; Luesch H; Schultz PG; Gray NS
Chem Biol; 2010 May; 17(5):537-47. PubMed ID: 20534351
[TBL] [Abstract][Full Text] [Related]
20. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Kobayashi A; Kang MI; Okawa H; Ohtsuji M; Zenke Y; Chiba T; Igarashi K; Yamamoto M
Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]