158 related articles for article (PubMed ID: 19492825)
1. Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin.
Hadden MK; Blagg BS
J Org Chem; 2009 Jul; 74(13):4697-704. PubMed ID: 19492825
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.
Clevenger RC; Blagg BS
Org Lett; 2004 Nov; 6(24):4459-62. PubMed ID: 15548050
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.
Shen G; Wang M; Welch TR; Blagg BS
J Org Chem; 2006 Sep; 71(20):7618-31. PubMed ID: 16995666
[TBL] [Abstract][Full Text] [Related]
4. Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.
Kitson RR; Moody CJ
J Org Chem; 2013 Jun; 78(11):5117-41. PubMed ID: 23496136
[TBL] [Abstract][Full Text] [Related]
5. Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site.
Hadden MK; Lubbers DJ; Blagg BS
Curr Top Med Chem; 2006; 6(11):1173-82. PubMed ID: 16842154
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors.
Duerfeldt AS; Brandt GE; Blagg BS
Org Lett; 2009 Jun; 11(11):2353-6. PubMed ID: 19435295
[TBL] [Abstract][Full Text] [Related]
7. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
Immormino RM; Metzger LE; Reardon PN; Dollins DE; Blagg BS; Gewirth DT
J Mol Biol; 2009 May; 388(5):1033-42. PubMed ID: 19361515
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.
Lee K; Ryu JS; Jin Y; Kim W; Kaur N; Chung SJ; Jeon YJ; Park JT; Bang JS; Lee HS; Kim TY; Lee JJ; Hong YS
Org Biomol Chem; 2008 Jan; 6(2):340-8. PubMed ID: 18175003
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors.
Jadhav VD; Duerfeldt AS; Blagg BS
Bioorg Med Chem Lett; 2009 Dec; 19(24):6845-50. PubMed ID: 19896848
[TBL] [Abstract][Full Text] [Related]
10. Radanamycin, a macrocyclic chimera of radicicol and geldanamycin.
Wang M; Shen G; Blagg BS
Bioorg Med Chem Lett; 2006 May; 16(9):2459-62. PubMed ID: 16464590
[TBL] [Abstract][Full Text] [Related]
11. Potent cytotoxic C-11 modified geldanamycin analogues.
Tian ZQ; Wang Z; MacMillan KS; Zhou Y; Carreras CW; Mueller T; Myles DC; Liu Y
J Med Chem; 2009 May; 52(10):3265-73. PubMed ID: 19405528
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
Le Brazidec JY; Kamal A; Busch D; Thao L; Zhang L; Timony G; Grecko R; Trent K; Lough R; Salazar T; Khan S; Burrows F; Boehm MF
J Med Chem; 2004 Jul; 47(15):3865-73. PubMed ID: 15239664
[TBL] [Abstract][Full Text] [Related]
13. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Roe SM; Prodromou C; O'Brien R; Ladbury JE; Piper PW; Pearl LH
J Med Chem; 1999 Jan; 42(2):260-6. PubMed ID: 9925731
[TBL] [Abstract][Full Text] [Related]
14. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.
Schulte TW; Akinaga S; Soga S; Sullivan W; Stensgard B; Toft D; Neckers LM
Cell Stress Chaperones; 1998 Jun; 3(2):100-8. PubMed ID: 9672245
[TBL] [Abstract][Full Text] [Related]
15. Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.
Piper PW; Millson SH
Open Biol; 2012 Dec; 2(12):120138. PubMed ID: 23271830
[TBL] [Abstract][Full Text] [Related]
16. Geldanamycin and its derivatives as Hsp90 inhibitors.
Gorska M; Popowska U; Sielicka-Dudzin A; Kuban-Jankowska A; Sawczuk W; Knap N; Cicero G; Wozniak F
Front Biosci (Landmark Ed); 2012 Jun; 17(6):2269-77. PubMed ID: 22652777
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.
Li Z; Jia L; Wang J; Wu X; Shi G; Lu C; Shen Y
Chem Biol Drug Des; 2015 Feb; 85(2):181-8. PubMed ID: 24903735
[TBL] [Abstract][Full Text] [Related]
18. Structure-based and in silico design of Hsp90 inhibitors.
Sgobba M; Rastelli G
ChemMedChem; 2009 Sep; 4(9):1399-409. PubMed ID: 19685544
[TBL] [Abstract][Full Text] [Related]
19. Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
Zhao YR; Li HM; Zhu M; Li J; Ma T; Huo Q; Hong YS; Wu CZ
J Microbiol Biotechnol; 2018 Apr; 28(4):542-550. PubMed ID: 29618179
[TBL] [Abstract][Full Text] [Related]
20. An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.
Kitson RR; Moody CJ
Chem Commun (Camb); 2013 Oct; 49(76):8441-3. PubMed ID: 23770604
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]