156 related articles for article (PubMed ID: 19501510)
1. SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.
Mantell SJ; Stephenson PT; Monaghan SM; Maw GN; Trevethick MA; Yeadon M; Walker DK; Selby MD; Batchelor DV; Rozze S; Chavaroche H; Lemaitre A; Wright KN; Whitlock L; Stuart EF; Wright PA; Macintyre F
Bioorg Med Chem Lett; 2009 Aug; 19(15):4471-5. PubMed ID: 19501510
[TBL] [Abstract][Full Text] [Related]
2. Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.
Mantell SJ; Stephenson PT; Monaghan SM; Maw GN; Trevethick MA; Yeadon M; Keir RF; Walker DK; Jones RM; Selby MD; Batchelor DV; Rozze S; Chavaroche H; Hobson TJ; Dodd PG; Lemaitre A; Wright KN; Stuart EF
Bioorg Med Chem Lett; 2008 Feb; 18(4):1284-7. PubMed ID: 18243699
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Shah U; Lankin CM; Boyle CD; Chackalamannil S; Greenlee WJ; Neustadt BR; Cohen-Williams ME; Higgins GA; Ng K; Varty GB; Zhang H; Lachowicz JE
Bioorg Med Chem Lett; 2008 Jul; 18(14):4204-9. PubMed ID: 18558486
[TBL] [Abstract][Full Text] [Related]
4. Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists.
Shah U; Boyle CD; Chackalamannil S; Neustadt BR; Lindo N; Greenlee WJ; Foster C; Arik L; Zhai Y; Ng K; Wang S; Monopoli A; Lachowicz JE
Bioorg Med Chem Lett; 2008 Jul; 18(14):4199-203. PubMed ID: 18562199
[TBL] [Abstract][Full Text] [Related]
5. 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.
Moorjani M; Luo Z; Lin E; Vong BG; Chen Y; Zhang X; Rueter JK; Gross RS; Lanier MC; Tellew JE; Williams JP; Lechner SM; Malany S; Santos M; Crespo MI; Díaz JL; Saunders J; Slee DH
Bioorg Med Chem Lett; 2008 Oct; 18(20):5402-5. PubMed ID: 18835161
[TBL] [Abstract][Full Text] [Related]
6. Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
Bedford ST; Benwell KR; Brooks T; Chen I; Comer M; Dugdale S; Haymes T; Jordan AM; Kennett GA; Knight AR; Klenke B; LeStrat L; Merrett A; Misra A; Lightowler S; Padfield A; Poullennec K; Reece M; Simmonite H; Wong M; Yule IA
Bioorg Med Chem Lett; 2009 Oct; 19(20):5945-9. PubMed ID: 19733067
[TBL] [Abstract][Full Text] [Related]
7. M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.
Budzik B; Wang Y; Shi D; Wang F; Xie H; Wan Z; Zhu C; Foley JJ; Nuthulaganti P; Kallal LA; Sarau HM; Morrow DM; Moore ML; Rivero RA; Palovich M; Salmon M; Belmonte KE; Laine DI; Jin J
Bioorg Med Chem Lett; 2009 Mar; 19(6):1686-90. PubMed ID: 19243945
[TBL] [Abstract][Full Text] [Related]
8. Highlights on the development of A(2A) adenosine receptor agonists and antagonists.
Cristalli G; Cacciari B; Dal Ben D; Lambertucci C; Moro S; Spalluto G; Volpini R
ChemMedChem; 2007 Mar; 2(3):260-81. PubMed ID: 17177231
[TBL] [Abstract][Full Text] [Related]
9. Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Wu Y; Li J; Wu J; Morgan P; Xu X; Rancati F; Vallese S; Raveglia L; Hotchandani R; Fuller N; Bard J; Cunningham K; Fish S; Krykbaev R; Tam S; Goldman SJ; Williams C; Mansour TS; Saiah E; Sypek J; Li W
Bioorg Med Chem Lett; 2012 Jan; 22(1):138-43. PubMed ID: 22153340
[TBL] [Abstract][Full Text] [Related]
10. Recent developments in adenosine A2A receptor ligands.
Cristalli G; Müller CE; Volpini R
Handb Exp Pharmacol; 2009; (193):59-98. PubMed ID: 19639279
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Humphries PS; Benbow JW; Bonin PD; Boyer D; Doran SD; Frisbie RK; Piotrowski DW; Balan G; Bechle BM; Conn EL; Dirico KJ; Oliver RM; Soeller WC; Southers JA; Yang X
Bioorg Med Chem Lett; 2009 May; 19(9):2400-3. PubMed ID: 19346127
[TBL] [Abstract][Full Text] [Related]
12. Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.
Gillespie RJ; Bamford SJ; Botting R; Comer M; Denny S; Gaur S; Griffin M; Jordan AM; Knight AR; Lerpiniere J; Leonardi S; Lightowler S; McAteer S; Merrett A; Misra A; Padfield A; Reece M; Saadi M; Selwood DL; Stratton GC; Surry D; Todd R; Tong X; Ruston V; Upton R; Weiss SM
J Med Chem; 2009 Jan; 52(1):33-47. PubMed ID: 19072055
[TBL] [Abstract][Full Text] [Related]
13. Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed-treatment comparison meta-analysis.
Baker WL; Baker EL; Coleman CI
Pharmacotherapy; 2009 Aug; 29(8):891-905. PubMed ID: 19637942
[TBL] [Abstract][Full Text] [Related]
14. Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.
Lee CB; Koh HC
Auton Neurosci; 2009 Mar; 146(1-2):70-5. PubMed ID: 19138885
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and SAR of tolylamine 5-HT6 antagonists.
Singer JM; Wilson MW; Johnson PD; Graham SR; Cooke LW; Roof RL; Boxer PA; Gold LH; Meltzer LT; Janssen A; Roush N; Campbell JE; Su TZ; Hurst SI; Stoner CL; Schwarz JB
Bioorg Med Chem Lett; 2009 May; 19(9):2409-12. PubMed ID: 19346128
[TBL] [Abstract][Full Text] [Related]
16. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
Gillespie RJ; Cliffe IA; Dawson CE; Dourish CT; Gaur S; Jordan AM; Knight AR; Lerpiniere J; Misra A; Pratt RM; Roffey J; Stratton GC; Upton R; Weiss SM; Williamson DS
Bioorg Med Chem Lett; 2008 May; 18(9):2924-9. PubMed ID: 18411049
[TBL] [Abstract][Full Text] [Related]
17. Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.
Madsen-Duggan CB; Debenham JS; Walsh TF; Toupence RB; Huang SX; Wang J; Tong X; Lao J; Fong TM; Schaeffer MT; Xiao JC; Huang CR; Shen CP; Stribling DS; Shearman LP; Strack AM; MacIntyre DE; Van der Ploeg LH; Goulet MT
Bioorg Med Chem Lett; 2007 Apr; 17(7):2031-5. PubMed ID: 17270441
[TBL] [Abstract][Full Text] [Related]
18. Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.
Ryckmans T; Edwards MP; Horne VA; Correia AM; Owen DR; Thompson LR; Tran I; Tutt MF; Young T
Bioorg Med Chem Lett; 2009 Aug; 19(15):4406-9. PubMed ID: 19500981
[TBL] [Abstract][Full Text] [Related]
19. Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Debenham JS; Madsen-Duggan CB; Wang J; Tong X; Lao J; Fong TM; Schaeffer MT; Xiao JC; Huang CC; Shen CP; Sloan Stribling D; Shearman LP; Strack AM; Euan Macintyre D; Hale JJ; Walsh TF
Bioorg Med Chem Lett; 2009 May; 19(9):2591-4. PubMed ID: 19328684
[TBL] [Abstract][Full Text] [Related]
20. Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
McAtee JJ; Dodson JW; Dowdell SE; Erhard K; Girard GR; Goodman KB; Hilfiker MA; Jin J; Sehon CA; Sha D; Shi D; Wang F; Wang GZ; Wang N; Wang Y; Viet AQ; Yuan CC; Zhang D; Aiyar NV; Behm DJ; Carballo LH; Evans CA; Fries HE; Nagilla R; Roethke TJ; Xu X; Douglas SA; Neeb MJ
Bioorg Med Chem Lett; 2008 Jul; 18(13):3716-9. PubMed ID: 18524591
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]