243 related articles for article (PubMed ID: 19507864)
1. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.
Vandyck K; Cummings MD; Nyanguile O; Boutton CW; Vendeville S; McGowan D; Devogelaere B; Amssoms K; Last S; Rombauts K; Tahri A; Lory P; Hu L; Beauchamp DA; Simmen K; Raboisson P
J Med Chem; 2009 Jul; 52(14):4099-102. PubMed ID: 19507864
[TBL] [Abstract][Full Text] [Related]
2. NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
Bessa LM; Launay H; Dujardin M; Cantrelle FX; Lippens G; Landrieu I; Schneider R; Hanoulle X
J Biol Chem; 2017 Nov; 292(44):18024-18043. PubMed ID: 28912275
[TBL] [Abstract][Full Text] [Related]
3. 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Nyanguile O; Pauwels F; Van den Broeck W; Boutton CW; Quirynen L; Ivens T; van der Helm L; Vandercruyssen G; Mostmans W; Delouvroy F; Dehertogh P; Cummings MD; Bonfanti JF; Simmen KA; Raboisson P
Antimicrob Agents Chemother; 2008 Dec; 52(12):4420-31. PubMed ID: 18852280
[TBL] [Abstract][Full Text] [Related]
4. The discovery of finger loop inhibitors of the hepatitis C virus NS5B polymerase: status and prospects for novel HCV therapeutics.
Beaulieu PL
IDrugs; 2006 Jan; 9(1):39-43. PubMed ID: 16374732
[TBL] [Abstract][Full Text] [Related]
5. Dual Allosteric Inhibitors Jointly Modulate Protein Structure and Dynamics in the Hepatitis C Virus Polymerase.
Brown JA; Thorpe IF
Biochemistry; 2015 Jul; 54(26):4131-41. PubMed ID: 26066778
[TBL] [Abstract][Full Text] [Related]
6. Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.
Davis BC; Thorpe IF
Proteins; 2013 Jan; 81(1):40-52. PubMed ID: 22855387
[TBL] [Abstract][Full Text] [Related]
7. Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Biswal BK; Wang M; Cherney MM; Chan L; Yannopoulos CG; Bilimoria D; Bedard J; James MN
J Mol Biol; 2006 Aug; 361(1):33-45. PubMed ID: 16828488
[TBL] [Abstract][Full Text] [Related]
8. Ligand-induced changes in hepatitis C virus NS5B polymerase structure.
Rigat K; Wang Y; Hudyma TW; Ding M; Zheng X; Gentles RG; Beno BR; Gao M; Roberts SB
Antiviral Res; 2010 Nov; 88(2):197-206. PubMed ID: 20813137
[TBL] [Abstract][Full Text] [Related]
9. Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
Biswal BK; Cherney MM; Wang M; Chan L; Yannopoulos CG; Bilimoria D; Nicolas O; Bedard J; James MN
J Biol Chem; 2005 May; 280(18):18202-10. PubMed ID: 15746101
[TBL] [Abstract][Full Text] [Related]
10. Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Cheng CC; Shipps GW; Yang Z; Kawahata N; Lesburg CA; Duca JS; Bandouveres J; Bracken JD; Jiang CK; Agrawal S; Ferrari E; Huang HC
Bioorg Med Chem Lett; 2010 Apr; 20(7):2119-24. PubMed ID: 20219368
[TBL] [Abstract][Full Text] [Related]
11. 1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.
Nyanguile O; Devogelaere B; Vijgen L; Van den Broeck W; Pauwels F; Cummings MD; De Bondt HL; Vos AM; Berke JM; Lenz O; Vandercruyssen G; Vermeiren K; Mostmans W; Dehertogh P; Delouvroy F; Vendeville S; VanDyck K; Dockx K; Cleiren E; Raboisson P; Simmen KA; Fanning GC
J Virol; 2010 Mar; 84(6):2923-34. PubMed ID: 20071590
[TBL] [Abstract][Full Text] [Related]
12. Allosteric inhibition of the hepatitis C virus NS5B RNA dependent RNA polymerase.
Koch U; Narjes F
Infect Disord Drug Targets; 2006 Mar; 6(1):31-41. PubMed ID: 16787302
[TBL] [Abstract][Full Text] [Related]
13. Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
Beaulieu PL; Bös M; Bousquet Y; Fazal G; Gauthier J; Gillard J; Goulet S; LaPlante S; Poupart MA; Lefebvre S; McKercher G; Pellerin C; Austel V; Kukolj G
Bioorg Med Chem Lett; 2004 Jan; 14(1):119-24. PubMed ID: 14684311
[TBL] [Abstract][Full Text] [Related]
14. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
McKercher G; Beaulieu PL; Lamarre D; LaPlante S; Lefebvre S; Pellerin C; Thauvette L; Kukolj G
Nucleic Acids Res; 2004; 32(2):422-31. PubMed ID: 14739234
[TBL] [Abstract][Full Text] [Related]
15. Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.
Beaulieu PL
Curr Opin Investig Drugs; 2007 Aug; 8(8):614-34. PubMed ID: 17668364
[TBL] [Abstract][Full Text] [Related]
16. Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
Reddy TJ; Chan L; Turcotte N; Proulx M; Pereira OZ; Das SK; Siddiqui A; Wang W; Poisson C; Yannopoulos CG; Bilimoria D; L'Heureux L; Alaoui HM; Nguyen-Ba N
Bioorg Med Chem Lett; 2003 Oct; 13(19):3341-4. PubMed ID: 12951122
[TBL] [Abstract][Full Text] [Related]
17. Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
Donner PL; Xie Q; Pratt JK; Maring CJ; Kati W; Jiang W; Liu Y; Koev G; Masse S; Montgomery D; Molla A; Kempf DJ
Bioorg Med Chem Lett; 2008 Apr; 18(8):2735-8. PubMed ID: 18362072
[TBL] [Abstract][Full Text] [Related]
18. A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.
Ranjith-Kumar CT; Wen Y; Baxter N; Bhardwaj K; Cheng Kao C
PLoS One; 2011; 6(7):e22575. PubMed ID: 21799903
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
Barnes-Seeman D; Boiselle C; Capacci-Daniel C; Chopra R; Hoffmaster K; Jones CT; Kato M; Lin K; Ma S; Pan G; Shu L; Wang J; Whiteman L; Xu M; Zheng R; Fu J
Bioorg Med Chem Lett; 2014 Aug; 24(16):3979-85. PubMed ID: 24986660
[TBL] [Abstract][Full Text] [Related]
20. Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase.
Reich S; Golbik RP; Geissler R; Lilie H; Behrens SE
J Biol Chem; 2010 Apr; 285(18):13685-93. PubMed ID: 20194503
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
