These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

301 related articles for article (PubMed ID: 19513107)

  • 1. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
    Zeqiraj E; Filippi BM; Goldie S; Navratilova I; Boudeau J; Deak M; Alessi DR; van Aalten DM
    PLoS Biol; 2009 Jun; 7(6):e1000126. PubMed ID: 19513107
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
    Zeqiraj E; Filippi BM; Deak M; Alessi DR; van Aalten DM
    Science; 2009 Dec; 326(5960):1707-11. PubMed ID: 19892943
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Insights into the structural dynamics of Liver kinase B1 (LKB1) by the binding of STe20 Related Adapterα (STRADα) and Mouse protein 25α (MO25α) co-activators.
    Rungsung I; Ramaswamy A
    J Biomol Struct Dyn; 2017 Apr; 35(5):1138-1152. PubMed ID: 27160967
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of the LKB1-STRAD-MO25 complex.
    Boudeau J; Scott JW; Resta N; Deak M; Kieloch A; Komander D; Hardie DG; Prescott AR; van Aalten DM; Alessi DR
    J Cell Sci; 2004 Dec; 117(Pt 26):6365-75. PubMed ID: 15561763
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
    Boudeau J; Baas AF; Deak M; Morrice NA; Kieloch A; Schutkowski M; Prescott AR; Clevers HC; Alessi DR
    EMBO J; 2003 Oct; 22(19):5102-14. PubMed ID: 14517248
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
    Neumann D; Suter M; Tuerk R; Riek U; Wallimann T
    Mol Biotechnol; 2007 Jul; 36(3):220-31. PubMed ID: 17873408
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural insights into the activation of MST3 by MO25.
    Mehellou Y; Alessi DR; Macartney TJ; Szklarz M; Knapp S; Elkins JM
    Biochem Biophys Res Commun; 2013 Feb; 431(3):604-9. PubMed ID: 23296203
    [TBL] [Abstract][Full Text] [Related]  

  • 8. C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
    Fogarty S; Hardie DG
    J Biol Chem; 2009 Jan; 284(1):77-84. PubMed ID: 18854318
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of Peutz-Jeghers syndrome (PJS) causing missense mutations L67P, L182P, G242V and R297S on the structural dynamics of LKB1 (Liver kinase B1) protein.
    Rungsung I; Ramaswamy A
    J Biomol Struct Dyn; 2019 Feb; 37(3):796-810. PubMed ID: 29447078
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
    Baas AF; Boudeau J; Sapkota GP; Smit L; Medema R; Morrice NA; Alessi DR; Clevers HC
    EMBO J; 2003 Jun; 22(12):3062-72. PubMed ID: 12805220
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural insights into regulatory mechanisms of MO25-mediated kinase activation.
    Hao Q; Feng M; Shi Z; Li C; Chen M; Wang W; Zhang M; Jiao S; Zhou Z
    J Struct Biol; 2014 May; 186(2):224-33. PubMed ID: 24746913
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.
    Smith CD; Compton RA; Bowler JS; Kemp JT; Sudweeks SN; Thomson DM; Winder WW
    J Appl Physiol (1985); 2011 Dec; 111(6):1622-8. PubMed ID: 21903876
    [TBL] [Abstract][Full Text] [Related]  

  • 13. STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
    Dorfman J; Macara IG
    Mol Biol Cell; 2008 Apr; 19(4):1614-26. PubMed ID: 18256292
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
    Hawley SA; Boudeau J; Reid JL; Mustard KJ; Udd L; Mäkelä TP; Alessi DR; Hardie DG
    J Biol; 2003; 2(4):28. PubMed ID: 14511394
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
    Marignani PA; Scott KD; Bagnulo R; Cannone D; Ferrari E; Stella A; Guanti G; Simone C; Resta N
    Cancer Biol Ther; 2007 Oct; 6(10):1627-31. PubMed ID: 17921699
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
    Lizcano JM; Göransson O; Toth R; Deak M; Morrice NA; Boudeau J; Hawley SA; Udd L; Mäkelä TP; Hardie DG; Alessi DR
    EMBO J; 2004 Feb; 23(4):833-43. PubMed ID: 14976552
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
    ten Klooster JP; Jansen M; Yuan J; Oorschot V; Begthel H; Di Giacomo V; Colland F; de Koning J; Maurice MM; Hornbeck P; Clevers H
    Dev Cell; 2009 Apr; 16(4):551-62. PubMed ID: 19386264
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.
    Jaleel M; Villa F; Deak M; Toth R; Prescott AR; Van Aalten DM; Alessi DR
    Biochem J; 2006 Mar; 394(Pt 3):545-55. PubMed ID: 16396636
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.
    Smith RHB; Khan ZM; Ung PM; Scopton AP; Silber L; Mack SM; Real AM; Schlessinger A; Dar AC
    Biochemistry; 2021 Feb; 60(4):289-302. PubMed ID: 33440120
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
    Filippi BM; de los Heros P; Mehellou Y; Navratilova I; Gourlay R; Deak M; Plater L; Toth R; Zeqiraj E; Alessi DR
    EMBO J; 2011 May; 30(9):1730-41. PubMed ID: 21423148
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.