These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
7. Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. Ehmke V; Winkler E; Banner DW; Haap W; Schweizer WB; Rottmann M; Kaiser M; Freymond C; Schirmeister T; Diederich F ChemMedChem; 2013 Jun; 8(6):967-75. PubMed ID: 23658062 [TBL] [Abstract][Full Text] [Related]
8. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Irie O; Teno N; Lattmann R; Tintelnot-Blomley M; Missbach M J Med Chem; 2007 Feb; 50(4):591-4. PubMed ID: 17256925 [TBL] [Abstract][Full Text] [Related]
9. Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors. Qiao L; Baumann CA; Crysler CS; Ninan NS; Abad MC; Spurlino JC; Desjarlais RL; Kervinen J; Neeper MP; Bayoumy SS; Williams R; Deckman IC; Dasgupta M; Reed RL; Huebert ND; Tomczuk BE; Moriarty KJ Bioorg Med Chem Lett; 2006 Jan; 16(1):123-8. PubMed ID: 16236500 [TBL] [Abstract][Full Text] [Related]
10. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. Altmann E; Cowan-Jacob SW; Missbach M J Med Chem; 2004 Nov; 47(24):5833-6. PubMed ID: 15537340 [TBL] [Abstract][Full Text] [Related]
12. Dipeptide nitrile inhibitors of cathepsin K. Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Lattmann R; Missbach M Bioorg Med Chem Lett; 2006 May; 16(9):2549-54. PubMed ID: 16480867 [TBL] [Abstract][Full Text] [Related]
13. Development of nitrile-based peptidic inhibitors of cysteine cathepsins. Frizler M; Stirnberg M; Sisay MT; Gütschow M Curr Top Med Chem; 2010; 10(3):294-322. PubMed ID: 20166952 [TBL] [Abstract][Full Text] [Related]
14. Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors. Boyd MJ; Crane SN; Robichaud J; Scheigetz J; Black WC; Chauret N; Wang Q; Massé F; Oballa RM Bioorg Med Chem Lett; 2009 Feb; 19(3):675-9. PubMed ID: 19117756 [TBL] [Abstract][Full Text] [Related]
15. 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Cai J; Baugh M; Black D; Long C; Jonathan Bennett D; Dempster M; Fradera X; Gillespie J; Andrews F; Boucharens S; Bruin J; Cameron KS; Cumming I; Hamilton W; Jones PS; Kaptein A; Kinghorn E; Maidment M; Martin I; Mitchell A; Rankovic Z; Robinson J; Scullion P; Uitdehaag JC; Vink P; Westwood P; van Zeeland M; van Berkom L; Bastiani M; Meulemans T Bioorg Med Chem Lett; 2010 Aug; 20(15):4350-4. PubMed ID: 20598883 [TBL] [Abstract][Full Text] [Related]
16. Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bondebjerg J; Fuglsang H; Valeur KR; Pedersen J; Naerum L Bioorg Med Chem Lett; 2006 Jul; 16(13):3614-7. PubMed ID: 16647256 [TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Guay D; Beaulieu C; Truchon JF; Jagadeeswar Reddy T; Zamboni R; Bayly CI; Methot N; Rubin J; Ethier D; David Percival M Bioorg Med Chem Lett; 2009 Sep; 19(18):5392-6. PubMed ID: 19665376 [TBL] [Abstract][Full Text] [Related]
18. Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. Löser R; Schilling K; Dimmig E; Gütschow M J Med Chem; 2005 Dec; 48(24):7688-707. PubMed ID: 16302809 [TBL] [Abstract][Full Text] [Related]
19. Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors. Shenoy RT; Sivaraman J J Struct Biol; 2011 Jan; 173(1):14-9. PubMed ID: 20850545 [TBL] [Abstract][Full Text] [Related]
20. Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design. Greenspan PD; Clark KL; Tommasi RA; Cowen SD; McQuire LW; Farley DL; van Duzer JH; Goldberg RL; Zhou H; Du Z; Fitt JJ; Coppa DE; Fang Z; Macchia W; Zhu L; Capparelli MP; Goldstein R; Wigg AM; Doughty JR; Bohacek RS; Knap AK J Med Chem; 2001 Dec; 44(26):4524-34. PubMed ID: 11741472 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]