346 related articles for article (PubMed ID: 19522463)
1. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR; Lescarbeau A; Grogan MJ; Tan E; Lin G; Austad BC; Yu LC; Behnke ML; Nair SJ; Hagel M; White K; Conley J; Manna JD; Alvarez-Diez TM; Hoyt J; Woodward CN; Sydor JR; Pink M; MacDougall J; Campbell MJ; Cushing J; Ferguson J; Curtis MS; McGovern K; Read MA; Palombella VJ; Adams J; Castro AC
J Med Chem; 2009 Jul; 52(14):4400-18. PubMed ID: 19522463
[TBL] [Abstract][Full Text] [Related]
2. Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
Tremblay MR; Nevalainen M; Nair SJ; Porter JR; Castro AC; Behnke ML; Yu LC; Hagel M; White K; Faia K; Grenier L; Campbell MJ; Cushing J; Woodward CN; Hoyt J; Foley MA; Read MA; Sydor JR; Tong JK; Palombella VJ; McGovern K; Adams J
J Med Chem; 2008 Nov; 51(21):6646-9. PubMed ID: 18842035
[TBL] [Abstract][Full Text] [Related]
3. Modulators of the hedgehog signaling pathway.
Heretsch P; Tzagkaroulaki L; Giannis A
Bioorg Med Chem; 2010 Sep; 18(18):6613-24. PubMed ID: 20708941
[TBL] [Abstract][Full Text] [Related]
4. Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.
Tremblay MR; Nesler M; Weatherhead R; Castro AC
Expert Opin Ther Pat; 2009 Aug; 19(8):1039-56. PubMed ID: 19505195
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.
Winkler JD; Isaacs A; Holderbaum L; Tatard V; Dahmane N
Org Lett; 2009 Jul; 11(13):2824-7. PubMed ID: 19552464
[TBL] [Abstract][Full Text] [Related]
6. New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination.
Bar EE; Stearns D
Expert Opin Investig Drugs; 2008 Feb; 17(2):185-95. PubMed ID: 18230052
[TBL] [Abstract][Full Text] [Related]
7. Exo-cyclopamine--a stable and potent inhibitor of hedgehog-signaling.
Heretsch P; Büttner A; Tzagkaroulaki L; Zahn S; Kirchner B; Giannis A
Chem Commun (Camb); 2011 Jul; 47(26):7362-4. PubMed ID: 21589966
[TBL] [Abstract][Full Text] [Related]
8. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer.
Xu FG; Ma QY; Wang Z
Cancer Lett; 2009 Oct; 283(2):119-24. PubMed ID: 19232458
[TBL] [Abstract][Full Text] [Related]
9. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.
Elamin MH; Shinwari Z; Hendrayani SF; Al-Hindi H; Al-Shail E; Khafaga Y; Al-Kofide A; Aboussekhra A
Mol Carcinog; 2010 Mar; 49(3):302-14. PubMed ID: 20025076
[TBL] [Abstract][Full Text] [Related]
10. Role of hedgehog signaling in ovarian cancer.
Bhattacharya R; Kwon J; Ali B; Wang E; Patra S; Shridhar V; Mukherjee P
Clin Cancer Res; 2008 Dec; 14(23):7659-66. PubMed ID: 19047091
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of cyclopamine using a biomimetic and diastereoselective approach.
Giannis A; Heretsch P; Sarli V; Stössel A
Angew Chem Int Ed Engl; 2009; 48(42):7911-4. PubMed ID: 19591183
[No Abstract] [Full Text] [Related]
12. In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.
Sanchez P; Ruiz i Altaba A
Mech Dev; 2005 Feb; 122(2):223-30. PubMed ID: 15652709
[TBL] [Abstract][Full Text] [Related]
13. Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified.
Wilson SR; Strand MF; Krapp A; Rise F; Petersen D; Krauss S
J Pharm Biomed Anal; 2010 Sep; 52(5):707-13. PubMed ID: 20236786
[TBL] [Abstract][Full Text] [Related]
14. Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition.
El-Zaatari M; Grabowska AM; McKenzie AJ; Powe DG; Scotting PJ; Watson SA
Regul Pept; 2008 Feb; 146(1-3):131-9. PubMed ID: 17996964
[TBL] [Abstract][Full Text] [Related]
15. From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age.
Hovhannisyan A; Matz M; Gebhardt R
Planta Med; 2009 Oct; 75(13):1371-80. PubMed ID: 19639534
[TBL] [Abstract][Full Text] [Related]
16. GDC-0449-a potent inhibitor of the hedgehog pathway.
Robarge KD; Brunton SA; Castanedo GM; Cui Y; Dina MS; Goldsmith R; Gould SE; Guichert O; Gunzner JL; Halladay J; Jia W; Khojasteh C; Koehler MF; Kotkow K; La H; Lalonde RL; Lau K; Lee L; Marshall D; Marsters JC; Murray LJ; Qian C; Rubin LL; Salphati L; Stanley MS; Stibbard JH; Sutherlin DP; Ubhayaker S; Wang S; Wong S; Xie M
Bioorg Med Chem Lett; 2009 Oct; 19(19):5576-81. PubMed ID: 19716296
[TBL] [Abstract][Full Text] [Related]
17. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
Peluso MO; Campbell VT; Harari JA; Tibbitts TT; Proctor JL; Whitebread N; Conley JM; White KF; Kutok JL; Read MA; McGovern K; Faia KL
PLoS One; 2014; 9(3):e90534. PubMed ID: 24608250
[TBL] [Abstract][Full Text] [Related]
18. The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
Smith S; Hoyt J; Whitebread N; Manna J; Peluso M; Faia K; Campbell V; Tremblay M; Nair S; Grogan M; Castro A; Campbell M; Ferguson J; Arsenault B; Nevejans J; Carter B; Lee J; Dunbar J; McGovern K; Read M; Adams J; Constan A; Loewen G; Sydor J; Palombella V; Soglia J
Xenobiotica; 2013 Oct; 43(10):875-85. PubMed ID: 23527529
[TBL] [Abstract][Full Text] [Related]
19. Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.
McCarthy FR; Brown AJ
Biochem Biophys Res Commun; 2008 Aug; 373(1):109-12. PubMed ID: 18544338
[TBL] [Abstract][Full Text] [Related]
20. Hedgehog signaling in the murine melanoma microenvironment.
Geng L; Cuneo KC; Cooper MK; Wang H; Sekhar K; Fu A; Hallahan DE
Angiogenesis; 2007; 10(4):259-67. PubMed ID: 17762973
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
