BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

280 related articles for article (PubMed ID: 19539407)

  • 1. Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.
    Myllymäki MJ; Käsnänen H; Kataja AO; Lahtela-Kakkonen M; Saario SM; Poso A; Koskinen AM
    Eur J Med Chem; 2009 Oct; 44(10):4179-91. PubMed ID: 19539407
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.
    Myllymäki MJ; Saario SM; Kataja AO; Castillo-Melendez JA; Nevalainen T; Juvonen RO; Järvinen T; Koskinen AM
    J Med Chem; 2007 Aug; 50(17):4236-42. PubMed ID: 17665899
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
    Mor M; Rivara S; Lodola A; Plazzi PV; Tarzia G; Duranti A; Tontini A; Piersanti G; Kathuria S; Piomelli D
    J Med Chem; 2004 Oct; 47(21):4998-5008. PubMed ID: 15456244
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: design, synthesis and 3D-QSAR studies.
    Käsnänen H; Myllymäki MJ; Minkkilä A; Kataja AO; Saario SM; Nevalainen T; Koskinen AM; Poso A
    ChemMedChem; 2010 Feb; 5(2):213-31. PubMed ID: 20024981
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
    Minkkilä A; Myllymäki MJ; Saario SM; Castillo-Melendez JA; Koskinen AM; Fowler CJ; Leppänen J; Nevalainen T
    Eur J Med Chem; 2009 Jul; 44(7):2994-3008. PubMed ID: 19232787
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.
    Vila A; Rosengarth A; Piomelli D; Cravatt B; Marnett LJ
    Biochemistry; 2007 Aug; 46(33):9578-85. PubMed ID: 17649977
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
    Vincent F; Nguyen MT; Emerling DE; Kelly MG; Duncton MA
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6793-6. PubMed ID: 19850474
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
    Korhonen J; Kuusisto A; van Bruchem J; Patel JZ; Laitinen T; Navia-Paldanius D; Laitinen JT; Savinainen JR; Parkkari T; Nevalainen TJ
    Bioorg Med Chem; 2014 Dec; 22(23):6694-6705. PubMed ID: 25282655
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling.
    Käsnänen H; Minkkilä A; Taupila S; Patel JZ; Parkkari T; Lahtela-Kakkonen M; Saario SM; Nevalainen T; Poso A
    Eur J Pharm Sci; 2013 Jun; 49(3):423-33. PubMed ID: 23557840
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.
    Saario SM; Laitinen JT
    Basic Clin Pharmacol Toxicol; 2007 Nov; 101(5):287-93. PubMed ID: 17910610
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
    Timmons A; Seierstad M; Apodaca R; Epperson M; Pippel D; Brown S; Chang L; Scott B; Webb M; Chaplan SR; Breitenbucher JG
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2109-13. PubMed ID: 18289847
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
    Tarzia G; Duranti A; Gatti G; Piersanti G; Tontini A; Rivara S; Lodola A; Plazzi PV; Mor M; Kathuria S; Piomelli D
    ChemMedChem; 2006 Jan; 1(1):130-9. PubMed ID: 16892344
    [TBL] [Abstract][Full Text] [Related]  

  • 13. (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
    Holtfrerich A; Hanekamp W; Lehr M
    Eur J Med Chem; 2013 May; 63():64-75. PubMed ID: 23455058
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.
    Gattinoni S; De Simone C; Dallavalle S; Fezza F; Nannei R; Amadio D; Minetti P; Quattrociocchi G; Caprioli A; Borsini F; Cabri W; Penco S; Merlini L; Maccarrone M
    ChemMedChem; 2010 Mar; 5(3):357-60. PubMed ID: 20112328
    [No Abstract]   [Full Text] [Related]  

  • 15. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.
    Gulyas AI; Cravatt BF; Bracey MH; Dinh TP; Piomelli D; Boscia F; Freund TF
    Eur J Neurosci; 2004 Jul; 20(2):441-58. PubMed ID: 15233753
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
    Morera E; De Petrocellis L; Morera L; Moriello AS; Ligresti A; Nalli M; Woodward DF; Di Marzo V; Ortar G
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6806-9. PubMed ID: 19875281
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.
    Morera L; Labar G; Ortar G; Lambert DM
    Bioorg Med Chem; 2012 Nov; 20(21):6260-75. PubMed ID: 23036333
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs.
    Gaetani S; Dipasquale P; Romano A; Righetti L; Cassano T; Piomelli D; Cuomo V
    Int Rev Neurobiol; 2009; 85():57-72. PubMed ID: 19607961
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.
    Nicolussi S; Chicca A; Rau M; Rihs S; Soeberdt M; Abels C; Gertsch J
    Biochem Pharmacol; 2014 Dec; 92(4):669-89. PubMed ID: 25283614
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.
    Cisneros JA; Björklund E; González-Gil I; Hu Y; Canales A; Medrano FJ; Romero A; Ortega-Gutiérrez S; Fowler CJ; López-Rodríguez ML
    J Med Chem; 2012 Jan; 55(2):824-36. PubMed ID: 22185522
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.