422 related articles for article (PubMed ID: 19541609)
1. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Shackelford DB; Vasquez DS; Corbeil J; Wu S; Leblanc M; Wu CL; Vera DR; Shaw RJ
Proc Natl Acad Sci U S A; 2009 Jul; 106(27):11137-42. PubMed ID: 19541609
[TBL] [Abstract][Full Text] [Related]
2. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.
Faubert B; Vincent EE; Griss T; Samborska B; Izreig S; Svensson RU; Mamer OA; Avizonis D; Shackelford DB; Shaw RJ; Jones RG
Proc Natl Acad Sci U S A; 2014 Feb; 111(7):2554-9. PubMed ID: 24550282
[TBL] [Abstract][Full Text] [Related]
3. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling.
Wei C; Amos CI; Zhang N; Wang X; Rashid A; Walker CL; Behringer RR; Frazier ML
Clin Cancer Res; 2008 Feb; 14(4):1167-71. PubMed ID: 18281551
[TBL] [Abstract][Full Text] [Related]
4. Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
Tanwar PS; Kaneko-Tarui T; Zhang L; Tanaka Y; Crum CP; Teixeira JM
PLoS Genet; 2012; 8(8):e1002906. PubMed ID: 22916036
[TBL] [Abstract][Full Text] [Related]
5. Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.
Wei C; Amos CI; Zhang N; Zhu J; Wang X; Frazier ML
Cancer Lett; 2009 May; 277(2):149-54. PubMed ID: 19147279
[TBL] [Abstract][Full Text] [Related]
6. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.
Rossi DJ; Ylikorkala A; Korsisaari N; Salovaara R; Luukko K; Launonen V; Henkemeyer M; Ristimaki A; Aaltonen LA; Makela TP
Proc Natl Acad Sci U S A; 2002 Sep; 99(19):12327-32. PubMed ID: 12218179
[TBL] [Abstract][Full Text] [Related]
7. Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
Altamish M; Dahiya R; Singh AK; Mishra A; Aljabali AAA; Satija S; Mehta M; Dureja H; Prasher P; Negi P; Kapoor DN; Goyal R; Tambuwala MM; Chellappan DK; Dua K; Gupta G
Crit Rev Eukaryot Gene Expr; 2020; 30(3):245-252. PubMed ID: 32749111
[TBL] [Abstract][Full Text] [Related]
8. The LKB1 tumor suppressor negatively regulates mTOR signaling.
Shaw RJ; Bardeesy N; Manning BD; Lopez L; Kosmatka M; DePinho RA; Cantley LC
Cancer Cell; 2004 Jul; 6(1):91-9. PubMed ID: 15261145
[TBL] [Abstract][Full Text] [Related]
9. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
Huang X; Wullschleger S; Shpiro N; McGuire VA; Sakamoto K; Woods YL; McBurnie W; Fleming S; Alessi DR
Biochem J; 2008 Jun; 412(2):211-21. PubMed ID: 18387000
[TBL] [Abstract][Full Text] [Related]
10. Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression.
Ma Y; Zhang G; Fu X; Xia O; Zhan C; Li L; Wang Z; Wu B
Oncol Rep; 2010 Jun; 23(6):1569-76. PubMed ID: 20428811
[TBL] [Abstract][Full Text] [Related]
11. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.
Brugarolas J; Kaelin WG
Cancer Cell; 2004 Jul; 6(1):7-10. PubMed ID: 15261137
[TBL] [Abstract][Full Text] [Related]
12. Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.
Udd L; Katajisto P; Rossi DJ; Lepistö A; Lahesmaa AM; Ylikorkala A; Järvinen HJ; Ristimäki AP; Mäkelä TP
Gastroenterology; 2004 Oct; 127(4):1030-7. PubMed ID: 15480979
[TBL] [Abstract][Full Text] [Related]
13. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
Forcet C; Etienne-Manneville S; Gaude H; Fournier L; Debilly S; Salmi M; Baas A; Olschwang S; Clevers H; Billaud M
Hum Mol Genet; 2005 May; 14(10):1283-92. PubMed ID: 15800014
[TBL] [Abstract][Full Text] [Related]
14. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Corradetti MN; Inoki K; Bardeesy N; DePinho RA; Guan KL
Genes Dev; 2004 Jul; 18(13):1533-8. PubMed ID: 15231735
[TBL] [Abstract][Full Text] [Related]
15. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
Ylikorkala A; Avizienyte E; Tomlinson IP; Tiainen M; Roth S; Loukola A; Hemminki A; Johansson M; Sistonen P; Markie D; Neale K; Phillips R; Zauber P; Twama T; Sampson J; Järvinen H; Mäkelä TP; Aaltonen LA
Hum Mol Genet; 1999 Jan; 8(1):45-51. PubMed ID: 9887330
[TBL] [Abstract][Full Text] [Related]
16. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.
Wang ZJ; Ellis I; Zauber P; Iwama T; Marchese C; Talbot I; Xue WH; Yan ZY; Tomlinson I
J Pathol; 1999 May; 188(1):9-13. PubMed ID: 10398133
[TBL] [Abstract][Full Text] [Related]
17. Targeting LKB1 signaling in cancer.
Korsse SE; Peppelenbosch MP; van Veelen W
Biochim Biophys Acta; 2013 Apr; 1835(2):194-210. PubMed ID: 23287572
[TBL] [Abstract][Full Text] [Related]
18. Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
Tanwar PS; Kaneko-Tarui T; Zhang L; Teixeira JM
Hum Mol Genet; 2012 Oct; 21(20):4394-405. PubMed ID: 22791749
[TBL] [Abstract][Full Text] [Related]
19. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Katajisto P; Vaahtomeri K; Ekman N; Ventelä E; Ristimäki A; Bardeesy N; Feil R; DePinho RA; Mäkelä TP
Nat Genet; 2008 Apr; 40(4):455-9. PubMed ID: 18311138
[TBL] [Abstract][Full Text] [Related]
20. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]