286 related articles for article (PubMed ID: 19563534)
1. Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model.
Takashima K; Matsunaga N; Yoshimatsu M; Hazeki K; Kaisho T; Uekata M; Hazeki O; Akira S; Iizawa Y; Ii M
Br J Pharmacol; 2009 Aug; 157(7):1250-62. PubMed ID: 19563534
[TBL] [Abstract][Full Text] [Related]
2. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.
Kawamoto T; Ii M; Kitazaki T; Iizawa Y; Kimura H
Eur J Pharmacol; 2008 Apr; 584(1):40-8. PubMed ID: 18299127
[TBL] [Abstract][Full Text] [Related]
3. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Matsunaga N; Tsuchimori N; Matsumoto T; Ii M
Mol Pharmacol; 2011 Jan; 79(1):34-41. PubMed ID: 20881006
[TBL] [Abstract][Full Text] [Related]
4. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Ii M; Matsunaga N; Hazeki K; Nakamura K; Takashima K; Seya T; Hazeki O; Kitazaki T; Iizawa Y
Mol Pharmacol; 2006 Apr; 69(4):1288-95. PubMed ID: 16373689
[TBL] [Abstract][Full Text] [Related]
5. TAK-242 suppresses lipopolysaccharide-induced inflammation in human coronary artery endothelial cells.
Wei Z; Sun X; Xu Q; Zhang Y; Tian F; Sun H; Zheng H; Dai J
Pharmazie; 2016 Oct; 71(10):583-587. PubMed ID: 29441926
[TBL] [Abstract][Full Text] [Related]
6. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.
Sha T; Sunamoto M; Kitazaki T; Sato J; Ii M; Iizawa Y
Eur J Pharmacol; 2007 Oct; 571(2-3):231-9. PubMed ID: 17632100
[TBL] [Abstract][Full Text] [Related]
7. Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis.
Sha T; Iizawa Y; Ii M
Shock; 2011 Feb; 35(2):205-9. PubMed ID: 20720515
[TBL] [Abstract][Full Text] [Related]
8. TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells.
Hussey SE; Liang H; Costford SR; Klip A; DeFronzo RA; Sanchez-Avila A; Ely B; Musi N
Biosci Rep; 2012 Nov; 33(1):37-47. PubMed ID: 23050932
[TBL] [Abstract][Full Text] [Related]
9. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.
Roger T; Froidevaux C; Le Roy D; Reymond MK; Chanson AL; Mauri D; Burns K; Riederer BM; Akira S; Calandra T
Proc Natl Acad Sci U S A; 2009 Feb; 106(7):2348-52. PubMed ID: 19181857
[TBL] [Abstract][Full Text] [Related]
10. Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
Murphy M; Xiong Y; Pattabiraman G; Qiu F; Medvedev AE
J Biol Chem; 2015 Jul; 290(31):19218-32. PubMed ID: 26082489
[TBL] [Abstract][Full Text] [Related]
11. Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.
Dobrovolskaia MA; Medvedev AE; Thomas KE; Cuesta N; Toshchakov V; Ren T; Cody MJ; Michalek SM; Rice NR; Vogel SN
J Immunol; 2003 Jan; 170(1):508-19. PubMed ID: 12496438
[TBL] [Abstract][Full Text] [Related]
12. Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan.
Uehori J; Matsumoto M; Tsuji S; Akazawa T; Takeuchi O; Akira S; Kawata T; Azuma I; Toyoshima K; Seya T
Infect Immun; 2003 Aug; 71(8):4238-49. PubMed ID: 12874299
[TBL] [Abstract][Full Text] [Related]
13. Mycobacterium indicus pranii and Mycobacterium bovis BCG lead to differential macrophage activation in Toll-like receptor-dependent manner.
Kumar P; Tyagi R; Das G; Bhaskar S
Immunology; 2014 Oct; 143(2):258-68. PubMed ID: 24766519
[TBL] [Abstract][Full Text] [Related]
14. LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-κB pathway.
Zhong Y; Wu S; Yang Y; Li GQ; Meng L; Zheng QY; Li Y; Xu GL; Zhang KQ; Peng KF
J Cell Mol Med; 2020 Oct; 24(20):11936-11948. PubMed ID: 32881263
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4.
Stevens CW; Aravind S; Das S; Davis RL
Br J Pharmacol; 2013 Mar; 168(6):1421-9. PubMed ID: 23083095
[TBL] [Abstract][Full Text] [Related]
16. Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury.
Seki H; Tasaka S; Fukunaga K; Shiraishi Y; Moriyama K; Miyamoto K; Nakano Y; Matsunaga N; Takashima K; Matsumoto T; Ii M; Ishizaka A; Takeda J
Inflamm Res; 2010 Oct; 59(10):837-45. PubMed ID: 20387088
[TBL] [Abstract][Full Text] [Related]
17. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Yamamoto M; Sato S; Hemmi H; Sanjo H; Uematsu S; Kaisho T; Hoshino K; Takeuchi O; Kobayashi M; Fujita T; Takeda K; Akira S
Nature; 2002 Nov; 420(6913):324-9. PubMed ID: 12447441
[TBL] [Abstract][Full Text] [Related]
18. Immunoregulatory Role of MicroRNA-21 in Macrophages in Response to Bacillus Calmette-Guerin Infection Involves Modulation of the TLR4/MyD88 Signaling Pathway.
Xue X; Qiu Y; Yang HL
Cell Physiol Biochem; 2017; 42(1):91-102. PubMed ID: 28494464
[TBL] [Abstract][Full Text] [Related]
19. Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan.
Doz E; Rose S; Nigou J; Gilleron M; Puzo G; Erard F; Ryffel B; Quesniaux VF
J Biol Chem; 2007 Sep; 282(36):26014-25. PubMed ID: 17617634
[TBL] [Abstract][Full Text] [Related]
20. Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.
Fellner A; Barhum Y; Angel A; Perets N; Steiner I; Offen D; Lev N
Int J Mol Sci; 2017 Aug; 18(8):. PubMed ID: 28763002
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
