BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

613 related articles for article (PubMed ID: 19576871)

  • 1. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM; Oudshoorn MJ; Van Ommen B; Haenen GR; Van Bladeren PJ
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q; Zhu M
    Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.
    Ding X; Spink DC; Bhama JK; Sheng JJ; Vaz AD; Coon MJ
    Mol Pharmacol; 1996 Jun; 49(6):1113-21. PubMed ID: 8649351
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
    Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
    Ross MK; Pegram RA
    Toxicol Appl Pharmacol; 2004 Mar; 195(2):166-81. PubMed ID: 14998683
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N; Makino C; Murayama N
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry.
    Bu HZ; Zhao P; Dalvie DK; Pool WF
    Rapid Commun Mass Spectrom; 2007; 21(20):3317-22. PubMed ID: 17879390
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
    Iverson SL; Shen L; Anlar N; Bolton JL
    Chem Res Toxicol; 1996 Mar; 9(2):492-9. PubMed ID: 8839054
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
    Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
    Damsten MC; de Vlieger JS; Niessen WM; Irth H; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2008 Nov; 21(11):2181-7. PubMed ID: 18816075
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ; De Voss JJ; Hooper WD; Dickinson RG; Gillam EM
    Chem Res Toxicol; 1997 Sep; 10(9):1049-58. PubMed ID: 9305589
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.
    Bu HZ; Kang P; Deese AJ; Zhao P; Pool WF
    Drug Metab Dispos; 2005 Dec; 33(12):1920-4. PubMed ID: 16204461
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice.
    Zhuo X; Gu J; Zhang QY; Spink DC; Kaminsky LS; Ding X
    J Pharmacol Exp Ther; 1999 Feb; 288(2):463-71. PubMed ID: 9918546
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 31.