These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
203 related articles for article (PubMed ID: 19582595)
1. Role of human liver microsomes in in vitro metabolism of drugs-a review. Asha S; Vidyavathi M Appl Biochem Biotechnol; 2010 Mar; 160(6):1699-722. PubMed ID: 19582595 [TBL] [Abstract][Full Text] [Related]
2. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites. Dalvie D; Obach RS; Kang P; Prakash C; Loi CM; Hurst S; Nedderman A; Goulet L; Smith E; Bu HZ; Smith DA Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377 [TBL] [Abstract][Full Text] [Related]
3. Human hepatocytes: isolation, cryopreservation and applications in drug development. Li AP Chem Biol Interact; 2007 May; 168(1):16-29. PubMed ID: 17270162 [TBL] [Abstract][Full Text] [Related]
4. Use of intrinsic clearance for prediction of human hepatic clearance. Chao P; Uss AS; Cheng KC Expert Opin Drug Metab Toxicol; 2010 Feb; 6(2):189-98. PubMed ID: 20073997 [TBL] [Abstract][Full Text] [Related]
5. Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement. Hallifax D; Houston JB Drug Metab Dispos; 2006 Apr; 34(4):724-6; author reply 727. PubMed ID: 16552024 [No Abstract] [Full Text] [Related]
6. Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes. Jones HM; Hallifax D; Houston JB Drug Metab Dispos; 2004 May; 32(5):572-80. PubMed ID: 15100181 [TBL] [Abstract][Full Text] [Related]
7. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises. Miners JO; Knights KM; Houston JB; Mackenzie PI Biochem Pharmacol; 2006 May; 71(11):1531-9. PubMed ID: 16455060 [TBL] [Abstract][Full Text] [Related]
8. The metabolism of drugs in isolated rat hepatocytes. A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions. Billings RE; McMahon RE; Ashmore J; Wagle SR Drug Metab Dispos; 1977; 5(6):518-26. PubMed ID: 21776 [TBL] [Abstract][Full Text] [Related]
9. [Liver and drug metabolism]. Mikheeva OM Eksp Klin Gastroenterol; 2011; (2):121-4. PubMed ID: 21560652 [TBL] [Abstract][Full Text] [Related]
10. Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment. Engtrakul JJ; Foti RS; Strelevitz TJ; Fisher MB Drug Metab Dispos; 2005 Nov; 33(11):1621-7. PubMed ID: 16049128 [TBL] [Abstract][Full Text] [Related]
11. In vitro methods in human drug biotransformation research: implications for cancer chemotherapy. Hariparsad N; Sane RS; Strom SC; Desai PB Toxicol In Vitro; 2006 Mar; 20(2):135-53. PubMed ID: 16359840 [TBL] [Abstract][Full Text] [Related]
12. Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures. Hewitt NJ; Bühring KU; Dasenbrock J; Haunschild J; Ladstetter B; Utesch D Drug Metab Dispos; 2001 Jul; 29(7):1042-50. PubMed ID: 11408372 [TBL] [Abstract][Full Text] [Related]
13. Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo. Gómez-Lechón MJ; Castell JV; Donato MT Chem Biol Interact; 2007 May; 168(1):30-50. PubMed ID: 17134688 [TBL] [Abstract][Full Text] [Related]
14. Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions. Camenisch G; Umehara K Biopharm Drug Dispos; 2012 May; 33(4):179-94. PubMed ID: 22407504 [TBL] [Abstract][Full Text] [Related]
15. Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Valles B; Schiller CD; Coassolo P; De Sousa G; Wyss R; Jaeck D; Viger-Chougnet A; Rahmani R Drug Metab Dispos; 1995 Oct; 23(10):1051-7. PubMed ID: 8654192 [TBL] [Abstract][Full Text] [Related]
16. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Riley RJ; McGinnity DF; Austin RP Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954 [TBL] [Abstract][Full Text] [Related]
17. Xenobiotic metabolism and toxicity in primary monolayer cultures of hepatocytes. Holme JA NIPH Ann; 1985 Dec; 8(2):49-63. PubMed ID: 3908998 [TBL] [Abstract][Full Text] [Related]
18. [Advances and related issues in the use of in vitro methods to predict metabolic clearance rate of new drugs]. Zhang Q; Wang GJ Yao Xue Xue Bao; 2007 Oct; 42(10):1023-8. PubMed ID: 18229605 [TBL] [Abstract][Full Text] [Related]
19. An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant. Andersson TB; Sjöberg H; Hoffmann KJ; Boobis AR; Watts P; Edwards RJ; Lake BG; Price RJ; Renwick AB; Gómez-Lechón MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Goldfarb PS; Lewis DF; Corcos L; Guillouzo A; Taavitsainen P; Pelkonen O Drug Metab Dispos; 2001 May; 29(5):712-20. PubMed ID: 11302938 [TBL] [Abstract][Full Text] [Related]
20. Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Salonen JS; Nyman L; Boobis AR; Edwards RJ; Watts P; Lake BG; Price RJ; Renwick AB; Gómez-Lechón MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Guillouzo A; Corcos L; Goldfarb PS; Lewis DF; Taavitsainen P; Pelkonen O Drug Metab Dispos; 2003 Sep; 31(9):1093-102. PubMed ID: 12920164 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]