BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 19597516)

  • 1. Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions.
    Fong TM; Heymsfield SB
    Int J Obes (Lond); 2009 Sep; 33(9):947-55. PubMed ID: 19597516
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
    Fong TM; Guan XM; Marsh DJ; Shen CP; Stribling DS; Rosko KM; Lao J; Yu H; Feng Y; Xiao JC; Van der Ploeg LH; Goulet MT; Hagmann WK; Lin LS; Lanza TJ; Jewell JP; Liu P; Shah SK; Qi H; Tong X; Wang J; Xu SS; Francis B; Strack AM; MacIntyre DE; Shearman LP
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1013-22. PubMed ID: 17327489
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.
    Pavón FJ; Serrano A; Pérez-Valero V; Jagerovic N; Hernández-Folgado L; Bermúdez-Silva FJ; Macías M; Goya P; de Fonseca FR
    J Neuroendocrinol; 2008 May; 20 Suppl 1():116-23. PubMed ID: 18426510
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis.
    Hsiao WC; Shia KS; Wang YT; Yeh YN; Chang CP; Lin Y; Chen PH; Wu CH; Chao YS; Hung MS
    Diabetes Obes Metab; 2015 May; 17(5):495-504. PubMed ID: 25656402
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.
    Martín-García E; Burokas A; Martín M; Berrendero F; Rubí B; Kiesselbach C; Heyne A; Gispert JD; Millán O; Maldonado R
    J Neurochem; 2010 Mar; 112(5):1338-13351. PubMed ID: 20028452
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study.
    Takano A; Gulyás B; Varnäs K; Little PB; Noerregaard PK; Jensen NO; Elling CE; Halldin C
    Synapse; 2014 Mar; 68(3):89-97. PubMed ID: 24293119
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
    Addy C; Wright H; Van Laere K; Gantz I; Erondu N; Musser BJ; Lu K; Yuan J; Sanabria-Bohórquez SM; Stoch A; Stevens C; Fong TM; De Lepeleire I; Cilissen C; Cote J; Rosko K; Gendrano IN; Nguyen AM; Gumbiner B; Rothenberg P; de Hoon J; Bormans G; Depré M; Eng WS; Ravussin E; Klein S; Blundell J; Herman GA; Burns HD; Hargreaves RJ; Wagner J; Gottesdiener K; Amatruda JM; Heymsfield SB
    Cell Metab; 2008 Jan; 7(1):68-78. PubMed ID: 18177726
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice.
    Patel KN; Joharapurkar AA; Patel V; Kshirsagar SG; Bahekar R; Srivastava BK; Jain MR
    Can J Physiol Pharmacol; 2014 Dec; 92(12):975-83. PubMed ID: 25361428
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Feeding disorders and obesity.
    Cervino C; Vicennati V; Pasquali R; Pagotto U
    Curr Top Behav Neurosci; 2009; 1():373-85. PubMed ID: 21104392
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity.
    Hagmann WK
    Arch Pharm (Weinheim); 2008 Jul; 341(7):405-11. PubMed ID: 18574849
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction.
    Lipina C; Vaanholt LM; Davidova A; Mitchell SE; Storey-Gordon E; Hambly C; Irving AJ; Speakman JR; Hundal HS
    Aging Cell; 2016 Apr; 15(2):325-35. PubMed ID: 26757949
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.
    Pang Z; Wu NN; Zhao W; Chain DC; Schaffer E; Zhang X; Yamdagni P; Palejwala VA; Fan C; Favara SG; Dressler HM; Economides KD; Weinstock D; Cavallo JS; Naimi S; Galzin AM; Guillot E; Pruniaux MP; Tocci MJ; Polites HG
    Obesity (Silver Spring); 2011 Oct; 19(10):1923-34. PubMed ID: 21799481
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
    Du W; Jewell JP; Lin LS; Colandrea VJ; Xiao JC; Lao J; Shen CP; Bateman TJ; Reddy VB; Ha SN; Shah SK; Fong TM; Hale JJ; Hagmann WK
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5195-9. PubMed ID: 19632830
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Taranabant cuts the fat: new hope for cannabinoid-based obesity therapies?
    Kirkham TC
    Cell Metab; 2008 Jan; 7(1):1-2. PubMed ID: 18177717
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
    Strack AM; Nicolich S; Faidley T; Achanfuo-Yeboah J; Cunningham PK; Hora D; Thompson D; Hickey G; Johnson-Levonas AO; Fong TM; Heymsfield SB
    Metabolism; 2012 Apr; 61(4):546-53. PubMed ID: 22001334
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes.
    Perwitz N; Wenzel J; Wagner I; Büning J; Drenckhan M; Zarse K; Ristow M; Lilienthal W; Lehnert H; Klein J
    Diabetes Obes Metab; 2010 Feb; 12(2):158-66. PubMed ID: 19895638
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier.
    Receveur JM; Murray A; Linget JM; Nørregaard PK; Cooper M; Bjurling E; Nielsen PA; Högberg T
    Bioorg Med Chem Lett; 2010 Jan; 20(2):453-7. PubMed ID: 20015647
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological comparison of traditional and non-traditional cannabinoid receptor 1 blockers in rodent models in vivo.
    Varga B; Kassai F; Szabó G; Kovács P; Fischer J; Gyertyán I
    Pharmacol Biochem Behav; 2017 Aug; 159():24-35. PubMed ID: 28666894
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity.
    Meye FJ; Trezza V; Vanderschuren LJ; Ramakers GM; Adan RA
    Mol Psychiatry; 2013 Dec; 18(12):1294-301. PubMed ID: 23070073
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study.
    Proietto J; Rissanen A; Harp JB; Erondu N; Yu Q; Suryawanshi S; Jones ME; Johnson-Levonas AO; Heymsfield SB; Kaufman KD; Amatruda JM
    Int J Obes (Lond); 2010 Aug; 34(8):1243-54. PubMed ID: 20212496
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.