503 related articles for article (PubMed ID: 19603119)
1. Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer.
Fluiter K; Mook OR; Vreijling J; Langkjaer N; Højland T; Wengel J; Baas F
Mol Biosyst; 2009 Aug; 5(8):838-43. PubMed ID: 19603119
[TBL] [Abstract][Full Text] [Related]
2. On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide.
Fluiter K; Frieden M; Vreijling J; Rosenbohm C; De Wissel MB; Christensen SM; Koch T; Ørum H; Baas F
Chembiochem; 2005 Jun; 6(6):1104-9. PubMed ID: 15861430
[TBL] [Abstract][Full Text] [Related]
3. Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Upadhayaya R; Deshpande SG; Li Q; Kardile RA; Sayyed AY; Kshirsagar EK; Salunke RV; Dixit SS; Zhou C; Földesi A; Chattopadhyaya J
J Org Chem; 2011 Jun; 76(11):4408-31. PubMed ID: 21500818
[TBL] [Abstract][Full Text] [Related]
4. Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
Li Q; Yuan F; Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2010 Sep; 75(18):6122-40. PubMed ID: 20738147
[TBL] [Abstract][Full Text] [Related]
5. LNA-antisense rivals siRNA for gene silencing.
Jepsen JS; Wengel J
Curr Opin Drug Discov Devel; 2004 Mar; 7(2):188-94. PubMed ID: 15603252
[TBL] [Abstract][Full Text] [Related]
6. Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.
Honcharenko D; Barman J; Varghese OP; Chattopadhyaya J
Biochemistry; 2007 May; 46(19):5635-46. PubMed ID: 17411072
[TBL] [Abstract][Full Text] [Related]
7. Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
Zhou C; Liu Y; Andaloussi M; Badgujar N; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 Jan; 74(1):118-34. PubMed ID: 19055352
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of conformationally locked Carba-LNAs through intramolecular free-radical addition to C=N. Electrostatic and steric implication of the carba-LNA substituents in the modified oligos for nuclease and thermodynamic stabilities.
Xu J; Liu Y; Dupouy C; Chattopadhyaya J
J Org Chem; 2009 Sep; 74(17):6534-54. PubMed ID: 19670835
[TBL] [Abstract][Full Text] [Related]
9. Gapmer Antisense Oligonucleotides Containing 2',3'-Dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing.
Danielsen MB; Lou C; Lisowiec-Wachnicka J; Pasternak A; Jørgensen PT; Wengel J
Chemistry; 2020 Jan; 26(6):1368-1379. PubMed ID: 31682037
[TBL] [Abstract][Full Text] [Related]
10. Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids.
Lima WF; Crooke ST
Biochemistry; 1997 Jan; 36(2):390-8. PubMed ID: 9003192
[TBL] [Abstract][Full Text] [Related]
11. Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts.
Mangos MM; Min KL; Viazovkina E; Galarneau A; Elzagheid MI; Parniak MA; Damha MJ
J Am Chem Soc; 2003 Jan; 125(3):654-61. PubMed ID: 12526664
[TBL] [Abstract][Full Text] [Related]
12. Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
Srivastava P; Barman J; Pathmasiri W; Plashkevych O; Wenska M; Chattopadhyaya J
J Am Chem Soc; 2007 Jul; 129(26):8362-79. PubMed ID: 17552524
[TBL] [Abstract][Full Text] [Related]
13. Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 May; 74(9):3248-65. PubMed ID: 19348480
[TBL] [Abstract][Full Text] [Related]
14. Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.
Frieden M; Christensen SM; Mikkelsen ND; Rosenbohm C; Thrue CA; Westergaard M; Hansen HF; Ørum H; Koch T
Nucleic Acids Res; 2003 Nov; 31(21):6365-72. PubMed ID: 14576324
[TBL] [Abstract][Full Text] [Related]
15. Design of antisense oligonucleotides stabilized by locked nucleic acids.
Kurreck J; Wyszko E; Gillen C; Erdmann VA
Nucleic Acids Res; 2002 May; 30(9):1911-8. PubMed ID: 11972327
[TBL] [Abstract][Full Text] [Related]
16. Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.
Campbell MA; Wengel J
Chem Soc Rev; 2011 Dec; 40(12):5680-9. PubMed ID: 21556437
[TBL] [Abstract][Full Text] [Related]
17. Induction of RNase H activity by Arabinose-peptide nucleic acid chimeras.
Pâtureau BM; Hudson RH; Damha MJ
Bioconjug Chem; 2007; 18(2):421-30. PubMed ID: 17373768
[TBL] [Abstract][Full Text] [Related]
18. Design of ENA gapmers as fine-tuning antisense oligonucleotides with sequence-specific inhibitory activity on mouse PADI4 mRNA expression.
Takagi-Sato M; Tokuhiro S; Kawaida R; Koizumi M
Nucleic Acids Symp Ser (Oxf); 2006; (50):319-20. PubMed ID: 17150946
[TBL] [Abstract][Full Text] [Related]
19. Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.
Okamoto S; Echigoya Y; Tago A; Segawa T; Sato Y; Itou T
Int J Mol Sci; 2023 Oct; 24(19):. PubMed ID: 37834294
[TBL] [Abstract][Full Text] [Related]
20. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
Plashkevych O; Li Q; Chattopadhyaya J
Mol Biosyst; 2017 May; 13(5):921-938. PubMed ID: 28352859
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
