BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 19616432)

  • 1. Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
    Fish PV; Wakenhut F; Ryckmans T; Stobie A
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4579-83. PubMed ID: 19616432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
    Wakenhut F; Allan GA; Fish PV; Fray MJ; Harrison AC; McCoy R; Phillips SC; Ryckmans T; Stobie A; Westbrook D; Westbrook SL; Whitlock GA
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5078-81. PubMed ID: 19647430
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
    Fish PV; Barta NS; Gray DL; Ryckmans T; Stobie A; Wakenhut F; Whitlock GA
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4355-9. PubMed ID: 18621528
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors.
    Xu W; Gray DL; Glase SA; Barta NS
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5550-3. PubMed ID: 18805691
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
    Fensome A; Goldberg J; McComas CC; Trybulski EJ; Woodworth RP; Deecher DC; Whiteside GT; Zhang P
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1555-8. PubMed ID: 20153188
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists.
    Zhou D; Gross JL; Sze JY; Adedoyin AB; Bowlby M; Di L; Platt BJ; Zhang G; Brandon N; Comery TA; Robichaud AJ
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5957-60. PubMed ID: 21843941
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
    Fish PV; Andrews MD; Jonathan Fray M; Stobie A; Wakenhut F; Whitlock GA
    Bioorg Med Chem Lett; 2009 May; 19(10):2829-34. PubMed ID: 19359175
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
    Dounay AB; Barta NS; Campbell BM; Coleman C; Collantes EM; Denny L; Dutta S; Gray DL; Hou D; Iyer R; Maiti SN; Ortwine DF; Probert A; Stratman NC; Subedi R; Whisman T; Xu W; Zoski K
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1114-7. PubMed ID: 20031410
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
    Hudson S; Kiankarimi M; Eccles W; Dwight W; Mostofi YS; Genicot MJ; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4491-4. PubMed ID: 18672364
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.
    Fish PV; Ryckmans T; Stobie A; Wakenhut F
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1795-8. PubMed ID: 18313294
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.
    Pettersson M; Campbell BM; Dounay AB; Gray DL; Xie L; O'Donnell CJ; Stratman NC; Zoski K; Drummond E; Bora G; Probert A; Whisman T
    Bioorg Med Chem Lett; 2011 Jan; 21(2):865-8. PubMed ID: 21185183
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
    Kim CY; Mahaney PE; McConnell O; Zhang Y; Manas E; Ho DM; Deecher DC; Trybulski EJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5029-32. PubMed ID: 19632110
    [TBL] [Abstract][Full Text] [Related]  

  • 13. N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
    Wakenhut F; Fish PV; Fray MJ; Gurrell I; Mills JE; Stobie A; Whitlock GA
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4308-11. PubMed ID: 18625557
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
    Bannwart LM; Carter DS; Cai HY; Choy JC; Greenhouse R; Jaime-Figueroa S; Iyer PS; Lin CJ; Lee EK; Lucas MC; Lynch SM; Madera AM; Moore A; Ozboya K; Raptova L; Roetz R; Schoenfeld RC; Stein KA; Steiner S; Villa M; Weikert RJ; Zhai Y
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6062-6. PubMed ID: 18954985
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.
    Sellitto I; Le Bourdonnec B; Worm K; Goodman A; Savolainen MA; Chu GH; Ajello CW; Saeui CT; Leister LK; Cassel JA; Dehaven RN; Labuda CJ; Koblish M; Little PJ; Brogdon BL; Smith SA; Dolle RE
    Bioorg Med Chem Lett; 2010 Jan; 20(1):387-91. PubMed ID: 19919895
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773).
    Stalder H; Hoener MC; Norcross RD
    Bioorg Med Chem Lett; 2011 Feb; 21(4):1227-31. PubMed ID: 21237643
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
    Wu D; Pontillo J; Ching B; Hudson S; Gao Y; Fleck BA; Gogas K; Wade WS
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4224-7. PubMed ID: 18550369
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist.
    Chen X; Pierce B; Naing W; Grapperhaus ML; Phillion DP
    Bioorg Med Chem Lett; 2010 May; 20(10):3107-11. PubMed ID: 20392639
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
    Vu AT; Cohn ST; Zhang P; Kim CY; Mahaney PE; Bray JA; Johnston GH; Koury EJ; Cosmi SA; Deecher DC; Smith VA; Harrison JE; Leventhal L; Whiteside GT; Kennedy JD; Trybulski EJ
    J Med Chem; 2010 Mar; 53(5):2051-62. PubMed ID: 20131864
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
    Cioffi CL; Wolf MA; Guzzo PR; Sadalapure K; Parthasarathy V; Dethe D; Maeng JH; Carulli E; Loong DT; Fang X; Hu M; Gupta P; Chung M; Bai M; Moore N; Luche M; Khmelnitsky Y; Love PL; Watson MA; Mhyre AJ; Liu S
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1257-61. PubMed ID: 23380375
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.