These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 19618917)

  • 21. Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.
    Barnett SA; Amyes TL; Wood BM; Gerlt JA; Richard JP
    Biochemistry; 2008 Jul; 47(30):7785-7. PubMed ID: 18598058
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
    Yew WS; Akana J; Wise EL; Rayment I; Gerlt JA
    Biochemistry; 2005 Feb; 44(6):1807-15. PubMed ID: 15697206
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.
    Toth K; Amyes TL; Wood BM; Chan K; Gerlt JA; Richard JP
    J Am Chem Soc; 2010 May; 132(20):7018-24. PubMed ID: 20441167
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.
    Hu H; Boone A; Yang W
    J Am Chem Soc; 2008 Nov; 130(44):14493-503. PubMed ID: 18839943
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.
    Miller BG; Snider MJ; Short SA; Wolfenden R
    Biochemistry; 2000 Jul; 39(28):8113-8. PubMed ID: 10889016
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization?
    Miller BG; Butterfoss GL; Short SA; Wolfenden R
    Biochemistry; 2001 May; 40(21):6227-32. PubMed ID: 11371183
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.
    Wood BM; Amyes TL; Fedorov AA; Fedorov EV; Shabila A; Almo SC; Richard JP; Gerlt JA
    Biochemistry; 2010 May; 49(17):3514-6. PubMed ID: 20369850
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase.
    Spong K; Amyes TL; Richard JP
    J Am Chem Soc; 2013 Dec; 135(49):18343-6. PubMed ID: 24274746
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase.
    Fujihashi M; Ishida T; Kuroda S; Kotra LP; Pai EF; Miki K
    J Am Chem Soc; 2013 Nov; 135(46):17432-43. PubMed ID: 24151964
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase.
    Yew WS; Wise EL; Rayment I; Gerlt JA
    Biochemistry; 2004 Jun; 43(21):6427-37. PubMed ID: 15157077
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A proficient enzyme: insights on the mechanism of orotidine monophosphate decarboxylase from computer simulations.
    Raugei S; Cascella M; Carloni P
    J Am Chem Soc; 2004 Dec; 126(48):15730-7. PubMed ID: 15571395
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation.
    Porter DJ; Short SA
    Biochemistry; 2000 Sep; 39(38):11788-800. PubMed ID: 10995247
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
    Appleby TC; Kinsland C; Begley TP; Ealick SE
    Proc Natl Acad Sci U S A; 2000 Feb; 97(5):2005-10. PubMed ID: 10681442
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structural basis for the decarboxylation of orotidine 5'-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase.
    Tokuoka K; Kusakari Y; Krungkrai SR; Matsumura H; Kai Y; Krungkrai J; Horii T; Inoue T
    J Biochem; 2008 Jan; 143(1):69-78. PubMed ID: 17981823
    [TBL] [Abstract][Full Text] [Related]  

  • 35. QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.
    Stanton CL; Kuo IF; Mundy CJ; Laino T; Houk KN
    J Phys Chem B; 2007 Nov; 111(43):12573-81. PubMed ID: 17927240
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Study of orotidine 5'-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation.
    Jamshidi S; Jalili S; Rafii-Tabar H
    J Biomol Struct Dyn; 2015; 33(2):404-17. PubMed ID: 24559040
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine- 5' -monophosphate decarboxylase.
    Shem DL; Gronert S; Wu W
    Bioorg Chem; 2004 Apr; 32(2):76-81. PubMed ID: 14990306
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Orotidine 5'-Monophosphate Decarboxylase: The Operation of Active Site Chains Within and Across Protein Subunits.
    Brandão TAS; Richard JP
    Biochemistry; 2020 Jun; 59(21):2032-2040. PubMed ID: 32374983
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase.
    Harris P; Poulsen JC; Jensen KF; Larsen S
    J Mol Biol; 2002 May; 318(4):1019-29. PubMed ID: 12054799
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase.
    Harris P; Navarro Poulsen JC; Jensen KF; Larsen S
    Biochemistry; 2000 Apr; 39(15):4217-24. PubMed ID: 10757968
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.