236 related articles for article (PubMed ID: 19622861)
1. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.
Patel SB; Cameron PM; O'Keefe SJ; Frantz-Wattley B; Thompson J; O'Neill EA; Tennis T; Liu L; Becker JW; Scapin G
Acta Crystallogr D Biol Crystallogr; 2009 Aug; 65(Pt 8):777-85. PubMed ID: 19622861
[TBL] [Abstract][Full Text] [Related]
2. Discovery and characterization of a substrate selective p38alpha inhibitor.
Davidson W; Frego L; Peet GW; Kroe RR; Labadia ME; Lukas SM; Snow RJ; Jakes S; Grygon CA; Pargellis C; Werneburg BG
Biochemistry; 2004 Sep; 43(37):11658-71. PubMed ID: 15362850
[TBL] [Abstract][Full Text] [Related]
3. Effect of the distal C162S mutation on the energetics of drug binding to p38alpha MAP kinase.
Todorova NA; Doseeva V; Ramprakash J; Schwarz FP
Arch Biochem Biophys; 2008 Jan; 469(2):232-42. PubMed ID: 17996717
[TBL] [Abstract][Full Text] [Related]
4. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
[TBL] [Abstract][Full Text] [Related]
5. Novel strategies for inhibition of the p38 MAPK pathway.
Zhang J; Shen B; Lin A
Trends Pharmacol Sci; 2007 Jun; 28(6):286-95. PubMed ID: 17482683
[TBL] [Abstract][Full Text] [Related]
6. Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.
Lee WH; Liu FH; Lee YL; Huang HM
J Biochem; 2010 May; 147(5):645-50. PubMed ID: 20053787
[TBL] [Abstract][Full Text] [Related]
7. Improved expression, purification, and crystallization of p38alpha MAP kinase.
Bukhtiyarova M; Northrop K; Chai X; Casper D; Karpusas M; Springman E
Protein Expr Purif; 2004 Sep; 37(1):154-61. PubMed ID: 15294293
[TBL] [Abstract][Full Text] [Related]
8. Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.
Goldstein DM; Alfredson T; Bertrand J; Browner MF; Clifford K; Dalrymple SA; Dunn J; Freire-Moar J; Harris S; Labadie SS; La Fargue J; Lapierre JM; Larrabee S; Li F; Papp E; McWeeney D; Ramesha C; Roberts R; Rotstein D; San Pablo B; Sjogren EB; So OY; Talamas FX; Tao W; Trejo A; Villasenor A; Welch M; Welch T; Weller P; Whiteley PE; Young K; Zipfel S
J Med Chem; 2006 Mar; 49(5):1562-75. PubMed ID: 16509574
[TBL] [Abstract][Full Text] [Related]
9. p38 MAP kinase inhibitors: many are made, but few are chosen.
Dominguez C; Powers DA; Tamayo N
Curr Opin Drug Discov Devel; 2005 Jul; 8(4):421-30. PubMed ID: 16022178
[TBL] [Abstract][Full Text] [Related]
10. Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.
Bukhtiyarova M; Karpusas M; Northrop K; Namboodiri HV; Springman EB
Biochemistry; 2007 May; 46(19):5687-96. PubMed ID: 17441692
[TBL] [Abstract][Full Text] [Related]
11. Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation.
Diskin R; Lebendiker M; Engelberg D; Livnah O
J Mol Biol; 2007 Jan; 365(1):66-76. PubMed ID: 17059827
[TBL] [Abstract][Full Text] [Related]
12. Computational sampling of a cryptic drug binding site in a protein receptor: explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase.
Frembgen-Kesner T; Elcock AH
J Mol Biol; 2006 May; 359(1):202-14. PubMed ID: 16616932
[TBL] [Abstract][Full Text] [Related]
13. Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Xing L; Shieh HS; Selness SR; Devraj RV; Walker JK; Devadas B; Hope HR; Compton RP; Schindler JF; Hirsch JL; Benson AG; Kurumbail RG; Stegeman RA; Williams JM; Broadus RM; Walden Z; Monahan JB
Biochemistry; 2009 Jul; 48(27):6402-11. PubMed ID: 19496616
[TBL] [Abstract][Full Text] [Related]
14. Dissection of the recognition properties of p38 MAP kinase. Determination of the binding mode of a new pyridinyl-heterocycle inhibitor family.
Soliva R; Gelpí JL; Almansa C; Virgili M; Orozco M
J Med Chem; 2007 Jan; 50(2):283-93. PubMed ID: 17228870
[TBL] [Abstract][Full Text] [Related]
15. Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Wurz RP; Pettus LH; Henkle B; Sherman L; Plant M; Miner K; McBride HJ; Wong LM; Saris CJ; Lee MR; Chmait S; Mohr C; Hsieh F; Tasker AS
Bioorg Med Chem Lett; 2010 Mar; 20(5):1680-4. PubMed ID: 20138761
[TBL] [Abstract][Full Text] [Related]
16. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
Simard JR; Getlik M; Grütter C; Pawar V; Wulfert S; Rabiller M; Rauh D
J Am Chem Soc; 2009 Sep; 131(37):13286-96. PubMed ID: 19572644
[TBL] [Abstract][Full Text] [Related]
17. X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
Azevedo R; van Zeeland M; Raaijmakers H; Kazemier B; de Vlieg J; Oubrie A
Acta Crystallogr D Biol Crystallogr; 2012 Aug; 68(Pt 8):1041-50. PubMed ID: 22868770
[TBL] [Abstract][Full Text] [Related]
18. A novel lipid binding site formed by the MAP kinase insert in p38 alpha.
Diskin R; Engelberg D; Livnah O
J Mol Biol; 2008 Jan; 375(1):70-9. PubMed ID: 17999933
[TBL] [Abstract][Full Text] [Related]
19. [The cellular location and significance of p38alpha/beta isoforms in the lumbar spinal cord of the bone cancer pain rats].
Dong H; Tian YK; Xiang HB; Tian XB; Jin XG
Zhonghua Yi Xue Za Zhi; 2007 Jan; 87(1):53-7. PubMed ID: 17403314
[TBL] [Abstract][Full Text] [Related]
20. Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β.
Melamed Kadosh D; Beenstock J; Engelberg D; Admon A
Int J Mol Sci; 2023 Aug; 24(15):. PubMed ID: 37569817
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
