These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
81 related articles for article (PubMed ID: 19631535)
1. Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand. Simeone JP; Braun MP; Leone JF; Lin P; DeVita RJ; Garcia-Calvo M; Bull HG; Lisnock J; Dean DC Bioorg Med Chem Lett; 2009 Sep; 19(17):5033-6. PubMed ID: 19631535 [TBL] [Abstract][Full Text] [Related]
2. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Garcia-Calvo M; Lisnock J; Bull HG; Hawes BE; Burnett DA; Braun MP; Crona JH; Davis HR; Dean DC; Detmers PA; Graziano MP; Hughes M; Macintyre DE; Ogawa A; O'neill KA; Iyer SP; Shevell DE; Smith MM; Tang YS; Makarewicz AM; Ujjainwalla F; Altmann SW; Chapman KT; Thornberry NA Proc Natl Acad Sci U S A; 2005 Jun; 102(23):8132-7. PubMed ID: 15928087 [TBL] [Abstract][Full Text] [Related]
3. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Ge L; Wang J; Qi W; Miao HH; Cao J; Qu YX; Li BL; Song BL Cell Metab; 2008 Jun; 7(6):508-19. PubMed ID: 18522832 [TBL] [Abstract][Full Text] [Related]
4. In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Hawes BE; O'neill KA; Yao X; Crona JH; Davis HR; Graziano MP; Altmann SW Mol Pharmacol; 2007 Jan; 71(1):19-29. PubMed ID: 17005902 [TBL] [Abstract][Full Text] [Related]
5. Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors. Frick W; Bauer-Schäfer A; Bauer J; Girbig F; Corsiero D; Heuer H; Kramer W Bioorg Med Chem; 2003 Apr; 11(8):1639-42. PubMed ID: 12659749 [TBL] [Abstract][Full Text] [Related]
6. Synthesis and in vitro evaluation of inhibitors of intestinal cholesterol absorption. Kvaernø L; Werder M; Hauser H; Carreira EM J Med Chem; 2005 Sep; 48(19):6035-53. PubMed ID: 16162006 [TBL] [Abstract][Full Text] [Related]
7. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Knöpfel M; Davies JP; Duong PT; Kvaernø L; Carreira EM; Phillips MC; Ioannou YA; Hauser H Biochim Biophys Acta; 2007 Sep; 1771(9):1140-7. PubMed ID: 17689140 [TBL] [Abstract][Full Text] [Related]
8. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Labonté ED; Howles PN; Granholm NA; Rojas JC; Davies JP; Ioannou YA; Hui DY Biochim Biophys Acta; 2007 Sep; 1771(9):1132-9. PubMed ID: 17442616 [TBL] [Abstract][Full Text] [Related]
9. Transporters as drug targets: discovery and development of NPC1L1 inhibitors. Betters JL; Yu L Clin Pharmacol Ther; 2010 Jan; 87(1):117-21. PubMed ID: 19907422 [TBL] [Abstract][Full Text] [Related]
10. NPC1L1: evolution from pharmacological target to physiological sterol transporter. Huff MW; Pollex RL; Hegele RA Arterioscler Thromb Vasc Biol; 2006 Nov; 26(11):2433-8. PubMed ID: 16973966 [TBL] [Abstract][Full Text] [Related]
11. A formal synthesis of ezetimibe via cycloaddition/rearrangement cascade reaction. Michalak M; Stodulski M; Stecko S; Mames A; Panfil I; Soluch M; Furman B; Chmielewski M J Org Chem; 2011 Aug; 76(16):6931-6. PubMed ID: 21744801 [TBL] [Abstract][Full Text] [Related]
12. An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach. Halleck M; Davis HR; Kirschmeier P; Levitan D; Snyder RD; Treinen K; Macdonald JS Toxicology; 2009 Apr; 258(2-3):116-30. PubMed ID: 19428931 [TBL] [Abstract][Full Text] [Related]
15. Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect. Karaki F; Ohgane K; Dodo K; Hashimoto Y Bioorg Med Chem; 2013 Sep; 21(17):5297-309. PubMed ID: 23830695 [TBL] [Abstract][Full Text] [Related]
16. Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. Chiba T; Sakurada T; Watanabe R; Yamaguchi K; Kimura Y; Kioka N; Kawagishi H; Matsuo M; Ueda K PLoS One; 2014; 9(12):e116162. PubMed ID: 25551765 [TBL] [Abstract][Full Text] [Related]
18. Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461. Dugar S; Clader JW; Chan TM; Davis H J Med Chem; 1995 Dec; 38(25):4875-7. PubMed ID: 8523398 [No Abstract] [Full Text] [Related]
19. Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions. Xu X; Fu R; Chen J; Chen S; Bai X Bioorg Med Chem Lett; 2007 Jan; 17(1):101-4. PubMed ID: 17049851 [TBL] [Abstract][Full Text] [Related]
20. Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake. Weinglass AB; Köhler MG; Nketiah EO; Liu J; Schmalhofer W; Thomas A; Williams B; Beers L; Smith L; Hafey M; Bleasby K; Leone J; Tang YS; Braun M; Ujjainwalla F; McCann ME; Kaczorowski GJ; Garcia ML Mol Pharmacol; 2008 Apr; 73(4):1072-84. PubMed ID: 18187582 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]