BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 19632110)

  • 1. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
    Kim CY; Mahaney PE; McConnell O; Zhang Y; Manas E; Ho DM; Deecher DC; Trybulski EJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5029-32. PubMed ID: 19632110
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
    Mahaney PE; Kim CY; Coghlan RD; Cohn ST; Heffernan GD; Huselton CA; Terefenko EA; Vu AT; Zhang P; Burroughs KD; Cosmi SA; Bray JA; Johnston GH; Deecher DC; Trybulski EJ
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5807-10. PubMed ID: 19713106
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
    Wu D; Pontillo J; Ching B; Hudson S; Gao Y; Fleck BA; Gogas K; Wade WS
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4224-7. PubMed ID: 18550369
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
    Hudson S; Kiankarimi M; Eccles W; Dwight W; Mostofi YS; Genicot MJ; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4491-4. PubMed ID: 18672364
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
    Zhang S; Fernandez F; Hazeldine S; Deschamps J; Zhen J; Reith ME; Dutta AK
    J Med Chem; 2006 Jul; 49(14):4239-47. PubMed ID: 16821783
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.
    Mahaney PE; Vu AT; McComas CC; Zhang P; Nogle LM; Watts WL; Sarkahian A; Leventhal L; Sullivan NR; Uveges AJ; Trybulski EJ
    Bioorg Med Chem; 2006 Dec; 14(24):8455-66. PubMed ID: 16973367
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
    Fensome A; Goldberg J; McComas CC; Trybulski EJ; Woodworth RP; Deecher DC; Whiteside GT; Zhang P
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1555-8. PubMed ID: 20153188
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
    Park JE; Song C; Choi K; Sim T; Moon B; Roh EJ
    Bioorg Med Chem Lett; 2013 Oct; 23(20):5515-8. PubMed ID: 24012181
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
    Dounay AB; Barta NS; Campbell BM; Coleman C; Collantes EM; Denny L; Dutta S; Gray DL; Hou D; Iyer R; Maiti SN; Ortwine DF; Probert A; Stratman NC; Subedi R; Whisman T; Xu W; Zoski K
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1114-7. PubMed ID: 20031410
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
    O'Neill DJ; Adedoyin A; Alfinito PD; Bray JA; Cosmi S; Deecher DC; Fensome A; Harrison J; Leventhal L; Mann C; McComas CC; Sullivan NR; Spangler TB; Uveges AJ; Trybulski EJ; Whiteside GT; Zhang P
    J Med Chem; 2010 Jun; 53(11):4511-21. PubMed ID: 20462211
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake.
    Boot JR; Brace G; Delatour CL; Dezutter N; Fairhurst J; Findlay J; Gallagher PT; Hoes I; Mahadevan S; Mitchell SN; Rathmell RE; Richards SJ; Simmonds RG; Wallace L; Whatton MA
    Bioorg Med Chem Lett; 2004 Nov; 14(21):5395-9. PubMed ID: 15454233
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract.
    Zhao G; Jiang ZH; Zheng XW; Zang SY; Guo LH
    Pharmacol Biochem Behav; 2008 Sep; 90(3):363-71. PubMed ID: 18485464
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
    Zhou D; Harrison BL; Shah U; Andree TH; Hornby GA; Scerni R; Schechter LE; Smith DL; Sullivan KM; Mewshaw RE
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1338-41. PubMed ID: 16332439
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
    Vu AT; Cohn ST; Terefenko EA; Moore WJ; Zhang P; Mahaney PE; Trybulski EJ; Goljer I; Dooley R; Bray JA; Johnston GH; Leiter J; Deecher DC
    Bioorg Med Chem Lett; 2009 May; 19(9):2464-7. PubMed ID: 19329313
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
    Zhang P; Terefenko EA; Bray J; Deecher D; Fensome A; Harrison J; Kim C; Koury E; Mark L; McComas CC; Mugford CA; Trybulski EJ; Vu AT; Whiteside GT; Mahaney PE
    J Med Chem; 2009 Sep; 52(18):5703-11. PubMed ID: 19722525
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
    Lee KH; Park CE; Min KH; Shin YJ; Chung CM; Kim HH; Yoon HJ; Won-Kim ; Ryu EJ; Shin YJ; Nam HS; Cho JW; Lee HY
    Bioorg Med Chem Lett; 2010 Sep; 20(18):5567-71. PubMed ID: 20724153
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Caulis Sinomenii extracts activate DA/NE transporter and inhibit 5HT transporter.
    Zhao G; Bi C; Qin GW; Guo LH
    Exp Biol Med (Maywood); 2009 Aug; 234(8):976-85. PubMed ID: 19491370
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
    Mahaney PE; Gavrin LK; Trybulski EJ; Stack GP; Vu TA; Cohn ST; Ye F; Belardi JK; Santilli AA; Sabatucci JP; Leiter J; Johnston GH; Bray JA; Burroughs KD; Cosmi SA; Leventhal L; Koury EJ; Zhang Y; Mugford CA; Ho DM; Rosenzweig-Lipson SJ; Platt B; Smith VA; Deecher DC
    J Med Chem; 2008 Jul; 51(13):4038-49. PubMed ID: 18557608
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
    Zhou D; Zhou P; Evrard DA; Meagher K; Webb M; Harrison BL; Huryn DM; Golembieski J; Hornby GA; Schechter LE; Smith DL; Andree TH; Mewshaw RE
    Bioorg Med Chem; 2008 Jul; 16(14):6707-23. PubMed ID: 18571421
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
    Vu AT; Cohn ST; Zhang P; Kim CY; Mahaney PE; Bray JA; Johnston GH; Koury EJ; Cosmi SA; Deecher DC; Smith VA; Harrison JE; Leventhal L; Whiteside GT; Kennedy JD; Trybulski EJ
    J Med Chem; 2010 Mar; 53(5):2051-62. PubMed ID: 20131864
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.