342 related articles for article (PubMed ID: 19632840)
1. Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.
Ando M; Sekino E; Haga Y; Moriya M; Ito M; Ito J; Iwaasa H; Ishihara A; Kanatani A; Ohtake N
Bioorg Med Chem Lett; 2009 Sep; 19(17):5186-90. PubMed ID: 19632840
[TBL] [Abstract][Full Text] [Related]
2. Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
Suzuki T; Kameda M; Ando M; Miyazoe H; Sekino E; Ito S; Masutani K; Kamijo K; Takezawa A; Moriya M; Ito M; Ito J; Nakase K; Matsushita H; Ishihara A; Takenaga N; Tokita S; Kanatani A; Sato N; Fukami T
Bioorg Med Chem Lett; 2009 Sep; 19(18):5339-45. PubMed ID: 19683441
[TBL] [Abstract][Full Text] [Related]
3. Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.
Kishino H; Moriya M; Sakuraba S; Sakamoto T; Takahashi H; Suzuki T; Moriya R; Ito M; Iwaasa H; Takenaga N; Ishihara A; Kanatani A; Sato N; Fukami T
Bioorg Med Chem Lett; 2009 Aug; 19(16):4589-93. PubMed ID: 19615899
[TBL] [Abstract][Full Text] [Related]
4. Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
Bioorg Med Chem Lett; 2008 Sep; 18(17):4859-63. PubMed ID: 18682323
[TBL] [Abstract][Full Text] [Related]
5. New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Cirauqui N; Ceras J; Galiano S; Pérez-Silanes S; Juanenea L; Rivera G; Aldana I; Monge A
Arzneimittelforschung; 2008; 58(11):585-91. PubMed ID: 19137910
[TBL] [Abstract][Full Text] [Related]
6. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
Suzuki T; Moriya M; Sakamoto T; Suga T; Kishino H; Takahashi H; Ishikawa M; Nagai K; Imai Y; Sekino E; Ito M; Iwaasa H; Ishihara A; Tokita S; Kanatani A; Sato N; Fukami T
Bioorg Med Chem Lett; 2009 Jun; 19(11):3072-7. PubMed ID: 19403308
[TBL] [Abstract][Full Text] [Related]
7. Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Sasmal PK; Sasmal S; Rao PT; Venkatesham B; Roshaiah M; Abbineni C; Khanna I; Jadhav VP; Suresh J; Talwar R; Muzeeb S; Receveur JM; Frimurer TM; Rist Ø; Elster L; Högberg T
Bioorg Med Chem Lett; 2010 Sep; 20(18):5443-8. PubMed ID: 20724156
[TBL] [Abstract][Full Text] [Related]
8. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
[TBL] [Abstract][Full Text] [Related]
9. Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
Guo T; Gu H; Hobbs DW; Busler DE; Rokosz LL
Bioorg Med Chem Lett; 2007 Mar; 17(6):1718-21. PubMed ID: 17251014
[TBL] [Abstract][Full Text] [Related]
10. 6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist.
Tavares FX; Al-Barazanji KA; Bishop MJ; Britt CS; Carlton DL; Cooper JP; Feldman PL; Garrido DM; Goetz AS; Grizzle MK; Hertzog DL; Ignar DM; Lang DG; McIntyre MS; Ott RJ; Peat AJ; Zhou HQ
J Med Chem; 2006 Nov; 49(24):7108-18. PubMed ID: 17125263
[TBL] [Abstract][Full Text] [Related]
11. Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.
Galiano S; Ceras J; Cirauqui N; Pérez S; Juanenea L; Rivera G; Aldana I; Monge A
Bioorg Med Chem; 2007 Jun; 15(11):3896-911. PubMed ID: 17407817
[TBL] [Abstract][Full Text] [Related]
12. A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
Clark DE; Higgs C; Wren SP; Dyke HJ; Wong M; Norman D; Lockey PM; Roach AG
J Med Chem; 2004 Jul; 47(16):3962-71. PubMed ID: 15267235
[TBL] [Abstract][Full Text] [Related]
13. An example of designed multiple ligands spanning protein classes: dual MCH-1R antagonists/DPPIV inhibitors.
Gattrell WT; Sambrook Smith CP; Smith AJ
Bioorg Med Chem Lett; 2012 Apr; 22(7):2464-9. PubMed ID: 22377519
[TBL] [Abstract][Full Text] [Related]
14. Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
Souers AJ; Gao J; Brune M; Bush E; Wodka D; Vasudevan A; Judd AS; Mulhern M; Brodjian S; Dayton B; Shapiro R; Hernandez LE; Marsh KC; Sham HL; Collins CA; Kym PR
J Med Chem; 2005 Mar; 48(5):1318-21. PubMed ID: 15743174
[TBL] [Abstract][Full Text] [Related]
15. Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.
Igawa H; Takahashi M; Kakegawa K; Kina A; Ikoma M; Aida J; Yasuma T; Kawata Y; Ashina S; Yamamoto S; Kundu M; Khamrai U; Hirabayashi H; Nakayama M; Nagisa Y; Kasai S; Maekawa T
J Med Chem; 2016 Feb; 59(3):1116-39. PubMed ID: 26736071
[TBL] [Abstract][Full Text] [Related]
16. Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
Vasudevan A; Souers AJ; Freeman JC; Verzal MK; Gao J; Mulhern MM; Wodka D; Lynch JK; Engstrom KM; Wagaw SH; Brodjian S; Dayton B; Falls DH; Bush E; Brune M; Shapiro RD; Marsh KC; Hernandez LE; Collins CA; Kym PR
Bioorg Med Chem Lett; 2005 Dec; 15(23):5293-7. PubMed ID: 16203136
[TBL] [Abstract][Full Text] [Related]
17. Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.
Ando M; Sato N; Nagase T; Nagai K; Ishikawa S; Takahashi H; Ohtake N; Ito J; Hirayama M; Mitobe Y; Iwaasa H; Gomori A; Matsushita H; Tadano K; Fujino N; Tanaka S; Ohe T; Ishihara A; Kanatani A; Fukami T
Bioorg Med Chem; 2009 Aug; 17(16):6106-22. PubMed ID: 19616955
[TBL] [Abstract][Full Text] [Related]
18. Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.
Igawa H; Takahashi M; Shirasaki M; Kakegawa K; Kina A; Ikoma M; Aida J; Yasuma T; Okuda S; Kawata Y; Noguchi T; Yamamoto S; Fujioka Y; Kundu M; Khamrai U; Nakayama M; Nagisa Y; Kasai S; Maekawa T
Bioorg Med Chem; 2016 Jun; 24(11):2486-2503. PubMed ID: 27112449
[TBL] [Abstract][Full Text] [Related]
19. Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Mihalic JT; Chen X; Fan P; Chen X; Fu Y; Liang L; Reed M; Tang L; Chen JL; Jaen J; Li L; Dai K
Bioorg Med Chem Lett; 2011 Dec; 21(23):7001-5. PubMed ID: 22019296
[TBL] [Abstract][Full Text] [Related]
20. Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists.
Haga Y; Mizutani S; Naya A; Kishino H; Iwaasa H; Ito M; Ito J; Moriya M; Sato N; Takenaga N; Ishihara A; Tokita S; Kanatani A; Ohtake N
Bioorg Med Chem; 2011 Jan; 19(2):883-93. PubMed ID: 21190859
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
