776 related articles for article (PubMed ID: 19635394)
1. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
Lin HC; Hsieh HM; Chen YH; Hu ML
Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
[TBL] [Abstract][Full Text] [Related]
2. S-Adenosylhomocysteine enhances DNA damage through increased β-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells.
Lin HC; Song TY; Hu ML
Toxicology; 2011 Dec; 290(2-3):342-9. PubMed ID: 22064374
[TBL] [Abstract][Full Text] [Related]
3. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
[TBL] [Abstract][Full Text] [Related]
4. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
[TBL] [Abstract][Full Text] [Related]
5. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
[TBL] [Abstract][Full Text] [Related]
6. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
[TBL] [Abstract][Full Text] [Related]
7. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
[TBL] [Abstract][Full Text] [Related]
8. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
Shimazawa M; Inokuchi Y; Okuno T; Nakajima Y; Sakaguchi G; Kato A; Oku H; Sugiyama T; Kudo T; Ikeda T; Takeda M; Hara H
J Neurochem; 2008 Oct; 107(1):279-90. PubMed ID: 18691390
[TBL] [Abstract][Full Text] [Related]
9. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
Mohmmad Abdul H; Sultana R; Keller JN; St Clair DK; Markesbery WR; Butterfield DA
J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
[TBL] [Abstract][Full Text] [Related]
10. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
[TBL] [Abstract][Full Text] [Related]
11. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
12. Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.
van Groen T; Kiliaan AJ; Kadish I
Neurobiol Dis; 2006 Sep; 23(3):653-62. PubMed ID: 16829076
[TBL] [Abstract][Full Text] [Related]
13. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B; Saftig P; Craessaerts K; Vanderstichele H; Guhde G; Annaert W; Von Figura K; Van Leuven F
Nature; 1998 Jan; 391(6665):387-90. PubMed ID: 9450754
[TBL] [Abstract][Full Text] [Related]
14. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
[TBL] [Abstract][Full Text] [Related]
15. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
[TBL] [Abstract][Full Text] [Related]
16. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
[TBL] [Abstract][Full Text] [Related]
17. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.
Wang PL; Niidome T; Akaike A; Kihara T; Sugimoto H
J Neurosci Res; 2009 Jul; 87(9):2105-14. PubMed ID: 19267423
[TBL] [Abstract][Full Text] [Related]
18. Temporal-spatial expression of presenilin 1 and the production of amyloid-beta after acute spinal cord injury in adult rat.
Kobayashi S; Sasaki T; Katayama T; Hasegawa T; Nagano A; Sato K
Neurochem Int; 2010 Feb; 56(3):387-93. PubMed ID: 19932144
[TBL] [Abstract][Full Text] [Related]
19. Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation.
Gallagher JJ; Minogue AM; Lynch MA
Neurodegener Dis; 2013; 11(1):33-41. PubMed ID: 22627185
[TBL] [Abstract][Full Text] [Related]
20. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]