190 related articles for article (PubMed ID: 19637873)
1. Divergent modes of enzyme inhibition in a homologous structure-activity series.
Ferreira RS; Bryant C; Ang KK; McKerrow JH; Shoichet BK; Renslo AR
J Med Chem; 2009 Aug; 52(16):5005-8. PubMed ID: 19637873
[TBL] [Abstract][Full Text] [Related]
2. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.
Roush WR; Cheng J; Knapp-Reed B; Alvarez-Hernandez A; McKerrow JH; Hansell E; Engel JC
Bioorg Med Chem Lett; 2001 Oct; 11(20):2759-62. PubMed ID: 11591518
[TBL] [Abstract][Full Text] [Related]
3. Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach.
de Souza ML; de Oliveira Rezende Junior C; Ferreira RS; Espinoza Chávez RM; Ferreira LLG; Slafer BW; Magalhães LG; Krogh R; Oliva G; Cruz FC; Dias LC; Andricopulo AD
J Chem Inf Model; 2020 Feb; 60(2):1028-1041. PubMed ID: 31765144
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.
dos Santos Filho JM; Leite AC; de Oliveira BG; Moreira DR; Lima MS; Soares MB; Leite LF
Bioorg Med Chem; 2009 Sep; 17(18):6682-91. PubMed ID: 19683450
[TBL] [Abstract][Full Text] [Related]
5. Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.
Burtoloso AC; de Albuquerque S; Furber M; Gomes JC; Gonçalez C; Kenny PW; Leitão A; Montanari CA; Quilles JC; Ribeiro JF; Rocha JR
PLoS Negl Trop Dis; 2017 Feb; 11(2):e0005343. PubMed ID: 28222138
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
Du X; Guo C; Hansell E; Doyle PS; Caffrey CR; Holler TP; McKerrow JH; Cohen FE
J Med Chem; 2002 Jun; 45(13):2695-707. PubMed ID: 12061873
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.
Chen YT; Lira R; Hansell E; McKerrow JH; Roush WR
Bioorg Med Chem Lett; 2008 Nov; 18(22):5860-3. PubMed ID: 18585034
[TBL] [Abstract][Full Text] [Related]
8. Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.
Trossini GH; Malvezzi A; T-do Amaral A; Rangel-Yagui CO; Izidoro MA; Cezari MH; Juliano L; Chin CM; Menezes CM; Ferreira EI
J Enzyme Inhib Med Chem; 2010 Feb; 25(1):62-7. PubMed ID: 20030510
[TBL] [Abstract][Full Text] [Related]
9. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.
Scheidt KA; Roush WR; McKerrow JH; Selzer PM; Hansell E; Rosenthal PJ
Bioorg Med Chem; 1998 Dec; 6(12):2477-94. PubMed ID: 9925304
[TBL] [Abstract][Full Text] [Related]
10. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors.
Pauli I; Ferreira LG; de Souza ML; Oliva G; Ferreira RS; Dessoy MA; Slafer BW; Dias LC; Andricopulo AD
Future Med Chem; 2017 May; 9(7):641-657. PubMed ID: 28509592
[TBL] [Abstract][Full Text] [Related]
11. Novel cruzain inhibitors for the treatment of Chagas' disease.
Rogers KE; Keränen H; Durrant JD; Ratnam J; Doak A; Arkin MR; McCammon JA
Chem Biol Drug Des; 2012 Sep; 80(3):398-405. PubMed ID: 22613098
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Novel Inhibitors of Cruzain Cysteine Protease of
Prates JLB; Lopes JR; Chin CM; Ferreira EI; Dos Santos JL; Scarim CB
Curr Med Chem; 2024; 31(16):2285-2308. PubMed ID: 37888814
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Espíndola JW; Cardoso MV; Filho GB; Oliveira E Silva DA; Moreira DR; Bastos TM; Simone CA; Soares MB; Villela FS; Ferreira RS; Castro MC; Pereira VR; Murta SM; Sales Junior PA; Romanha AJ; Leite AC
Eur J Med Chem; 2015 Aug; 101():818-35. PubMed ID: 26231082
[TBL] [Abstract][Full Text] [Related]
15. Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Pereira GAN; da Silva EB; Braga SFP; Leite PG; Martins LC; Vieira RP; Soh WT; Villela FS; Costa FMR; Ray D; de Andrade SF; Brandstetter H; Oliveira RB; Caffrey CR; Machado FS; Ferreira RS
Eur J Med Chem; 2019 Oct; 179():765-778. PubMed ID: 31284086
[TBL] [Abstract][Full Text] [Related]
16. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.
Huang L; Brinen LS; Ellman JA
Bioorg Med Chem; 2003 Jan; 11(1):21-9. PubMed ID: 12467703
[TBL] [Abstract][Full Text] [Related]
17. Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases.
Silva LR; Guimarães AS; do Nascimento J; do Santos Nascimento IJ; da Silva EB; McKerrow JH; Cardoso SH; da Silva-Júnior EF
Bioorg Med Chem; 2021 Jul; 41():116213. PubMed ID: 33992862
[TBL] [Abstract][Full Text] [Related]
18. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Mott BT; Ferreira RS; Simeonov A; Jadhav A; Ang KK; Leister W; Shen M; Silveira JT; Doyle PS; Arkin MR; McKerrow JH; Inglese J; Austin CP; Thomas CJ; Shoichet BK; Maloney DJ
J Med Chem; 2010 Jan; 53(1):52-60. PubMed ID: 19908842
[TBL] [Abstract][Full Text] [Related]
19. Structure-Based Virtual Screening and In Vitro Evaluation of New
Herrera-Mayorga V; Lara-Ramírez EE; Chacón-Vargas KF; Aguirre-Alvarado C; Rodríguez-Páez L; Alcántara-Farfán V; Cordero-Martínez J; Nogueda-Torres B; Reyes-Espinosa F; Bocanegra-García V; Rivera G
Int J Mol Sci; 2019 Apr; 20(7):. PubMed ID: 30970549
[TBL] [Abstract][Full Text] [Related]
20. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Chenna BC; Li L; Mellott DM; Zhai X; Siqueira-Neto JL; Calvet Alvarez C; Bernatchez JA; Desormeaux E; Alvarez Hernandez E; Gomez J; McKerrow JH; Cruz-Reyes J; Meek TD
J Med Chem; 2020 Mar; 63(6):3298-3316. PubMed ID: 32125159
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
