These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 19660030)

  • 1. Structural and biophysical characterization of XIAP BIR3 G306E mutant: insights in protein dynamics and application for fragment-based drug design.
    Moore CD; Wu H; Bolaños B; Bergqvist S; Brooun A; Pauly T; Nowlin D
    Chem Biol Drug Des; 2009 Sep; 74(3):212-23. PubMed ID: 19660030
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
    Mastrangelo E; Cossu F; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Drago C; Seneci P; Scolastico C; Rizzo V; Bolognesi M
    J Mol Biol; 2008 Dec; 384(3):673-89. PubMed ID: 18851976
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI.
    de Souza TL; Sanches D; Gonçalves RB; da RochaPita SS; Pascutti PG; Bianconi ML; de Almeida FC; Silva JL; de Oliveira AC
    Biophys Chem; 2010 Nov; 152(1-3):99-108. PubMed ID: 20843595
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
    Nikolovska-Coleska Z; Meagher JL; Jiang S; Kawamoto SA; Gao W; Yi H; Qin D; Roller PP; Stuckey JA; Wang S
    Anal Biochem; 2008 Mar; 374(1):87-98. PubMed ID: 18023397
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical basis for enhanced binding of peptide dimers to X-linked inhibitor of apoptosis protein.
    Splan KE; Allen JE; McLendon GL
    Biochemistry; 2007 Oct; 46(42):11938-44. PubMed ID: 17910418
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases.
    Abhari BA; Davoodi J
    J Mol Biol; 2008 Sep; 381(3):645-54. PubMed ID: 18619610
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
    Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
    J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
    Kulathila R; Vash B; Sage D; Cornell-Kennon S; Wright K; Koehn J; Stams T; Clark K; Price A
    Acta Crystallogr D Biol Crystallogr; 2009 Jan; 65(Pt 1):58-66. PubMed ID: 19153467
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics.
    Ling B; Dong L; Zhang R; Wang Z; Liu Y; Liu C
    J Mol Graph Model; 2010 Nov; 29(3):354-62. PubMed ID: 20980180
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.
    Sun H; Nikolovska-Coleska Z; Yang CY; Xu L; Tomita Y; Krajewski K; Roller PP; Wang S
    J Med Chem; 2004 Aug; 47(17):4147-50. PubMed ID: 15293984
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.
    Pfisterer PH; Shen C; Nikolovska-Coleska Z; Schyschka L; Schuster D; Rudy A; Wolber G; Vollmar AM; Rollinger JM; Stuppner H
    Bioorg Med Chem; 2011 Jan; 19(2):1002-9. PubMed ID: 21087868
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
    Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
    ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP-caspase interaction.
    Dudich E; Semenkova L; Dudich I; Denesyuk A; Tatulov E; Korpela T
    FEBS J; 2006 Aug; 273(16):3837-49. PubMed ID: 16869888
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
    Nikolovska-Coleska Z; Xu L; Hu Z; Tomita Y; Li P; Roller PP; Wang R; Fang X; Guo R; Zhang M; Lippman ME; Yang D; Wang S
    J Med Chem; 2004 May; 47(10):2430-40. PubMed ID: 15115387
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Non-peptidic small molecule inhibitors of XIAP.
    Park CM; Sun C; Olejniczak ET; Wilson AE; Meadows RP; Betz SF; Elmore SW; Fesik SW
    Bioorg Med Chem Lett; 2005 Feb; 15(3):771-5. PubMed ID: 15664855
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
    Sun H; Nikolovska-Coleska Z; Chen J; Yang CY; Tomita Y; Pan H; Yoshioka Y; Krajewski K; Roller PP; Wang S
    Bioorg Med Chem Lett; 2005 Feb; 15(3):793-7. PubMed ID: 15664859
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.
    Nikolovska-Coleska Z; Wang R; Fang X; Pan H; Tomita Y; Li P; Roller PP; Krajewski K; Saito NG; Stuckey JA; Wang S
    Anal Biochem; 2004 Sep; 332(2):261-73. PubMed ID: 15325294
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.
    Obiol-Pardo C; Granadino-Roldán JM; Rubio-Martinez J
    J Mol Recognit; 2008; 21(3):190-204. PubMed ID: 18438971
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs.
    Verhagen AM; Kratina TK; Hawkins CJ; Silke J; Ekert PG; Vaux DL
    Cell Death Differ; 2007 Feb; 14(2):348-57. PubMed ID: 16794601
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain.
    Orzáez M; Gortat A; Sancho M; Carbajo RJ; Pineda-Lucena A; Palacios-Rodríguez Y; Pérez-Payá E
    Apoptosis; 2011 May; 16(5):460-7. PubMed ID: 21340509
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.