225 related articles for article (PubMed ID: 19660467)
1. Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity.
Gao L; Chalupsky K; Stefani E; Cai H
J Mol Cell Cardiol; 2009 Dec; 47(6):752-60. PubMed ID: 19660467
[TBL] [Abstract][Full Text] [Related]
2. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice.
Siu KL; Miao XN; Cai H
PLoS One; 2014; 9(2):e88899. PubMed ID: 24558445
[TBL] [Abstract][Full Text] [Related]
3. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase.
Chalupsky K; Cai H
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):9056-61. PubMed ID: 15941833
[TBL] [Abstract][Full Text] [Related]
4. Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress.
Li H; Li Q; Zhang Y; Liu W; Gu B; Narumi T; Siu KL; Youn JY; Liu P; Yang X; Cai H
Hypertension; 2019 Jan; 73(1):179-189. PubMed ID: 30571557
[TBL] [Abstract][Full Text] [Related]
5. Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.
Chalupsky K; Kračun D; Kanchev I; Bertram K; Görlach A
Antioxid Redox Signal; 2015 Nov; 23(14):1076-91. PubMed ID: 26414244
[TBL] [Abstract][Full Text] [Related]
6. Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.
Whitsett J; Rangel Filho A; Sethumadhavan S; Celinska J; Widlansky M; Vasquez-Vivar J
Free Radic Biol Med; 2013 Oct; 63():143-50. PubMed ID: 23707606
[TBL] [Abstract][Full Text] [Related]
7. Characterization of folate-dependent enzymes and indices of folate status in laying hens supplemented with folic acid or 5-methyltetrahydrofolate.
Tactacan GB; Jing M; Thiessen S; Rodriguez-Lecompte JC; O'Connor DL; Guenter W; House JD
Poult Sci; 2010 Apr; 89(4):688-96. PubMed ID: 20308400
[TBL] [Abstract][Full Text] [Related]
8. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid.
Gao L; Siu KL; Chalupsky K; Nguyen A; Chen P; Weintraub NL; Galis Z; Cai H
Hypertension; 2012 Jan; 59(1):158-66. PubMed ID: 22083158
[TBL] [Abstract][Full Text] [Related]
9. Investigation on inhibitory effect of folic acid on methotrexate-induced epithelial-mesenchymal transition focusing on dihydrofolate reductase.
Kawami M; Honda N; Hara T; Yumoto R; Takano M
Drug Metab Pharmacokinet; 2019 Dec; 34(6):396-399. PubMed ID: 31601464
[TBL] [Abstract][Full Text] [Related]
10. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice.
Oak JH; Cai H
Diabetes; 2007 Jan; 56(1):118-26. PubMed ID: 17192473
[TBL] [Abstract][Full Text] [Related]
11. Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.
Cai Z; Lu Q; Ding Y; Wang Q; Xiao L; Song P; Zou MH
Arterioscler Thromb Vasc Biol; 2015 Nov; 35(11):2366-73. PubMed ID: 26381869
[TBL] [Abstract][Full Text] [Related]
12. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.
Huang K; Wang Y; Siu KL; Zhang Y; Cai H
Redox Biol; 2021 Jan; 38():101757. PubMed ID: 33126053
[TBL] [Abstract][Full Text] [Related]
13. Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk.
Zhao W; Yao M; Zhang Y; Xiong D; Dai G; Zhang J; Cao Y; Li H
Microvasc Res; 2022 Jul; 142():104348. PubMed ID: 35245516
[TBL] [Abstract][Full Text] [Related]
14. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
Pietrzik K; Bailey L; Shane B
Clin Pharmacokinet; 2010 Aug; 49(8):535-48. PubMed ID: 20608755
[TBL] [Abstract][Full Text] [Related]
15. eNOS Uncoupling: A Therapeutic Target For Ischemic Foot of Diabetic Rat.
Gao L; Yu A; Liu J; Ma L; Li J
Exp Clin Endocrinol Diabetes; 2019 May; 127(5):303-310. PubMed ID: 29390203
[TBL] [Abstract][Full Text] [Related]
16. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
Crabtree MJ; Tatham AL; Hale AB; Alp NJ; Channon KM
J Biol Chem; 2009 Oct; 284(41):28128-28136. PubMed ID: 19666465
[TBL] [Abstract][Full Text] [Related]
17. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.
Sugiyama T; Levy BD; Michel T
J Biol Chem; 2009 May; 284(19):12691-700. PubMed ID: 19286667
[TBL] [Abstract][Full Text] [Related]
18. Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.
Sánchez-del-Campo L; Chazarra S; Montenegro MF; Cabezas-Herrera J; Rodríguez-López JN
J Cell Biochem; 2010 Aug; 110(6):1399-409. PubMed ID: 20564235
[TBL] [Abstract][Full Text] [Related]
19. NOX isoforms in the development of abdominal aortic aneurysm.
Siu KL; Li Q; Zhang Y; Guo J; Youn JY; Du J; Cai H
Redox Biol; 2017 Apr; 11():118-125. PubMed ID: 27912196
[TBL] [Abstract][Full Text] [Related]
20. Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols.
Kao TT; Wang KC; Chang WN; Lin CY; Chen BH; Wu HL; Shi GY; Tsai JN; Fu TF
Drug Metab Dispos; 2008 Mar; 36(3):508-16. PubMed ID: 18056255
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]