BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

100 related articles for article (PubMed ID: 1967653)

  • 1. Analogues of carbamyl aspartate as inhibitors of dihydroorotase: preparation of boronic acid transition-state analogues and a zinc chelator carbamylhomocysteine.
    Kinder DH; Frank SK; Ames MM
    J Med Chem; 1990 Feb; 33(2):819-23. PubMed ID: 1967653
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of tetrahedral intermediate analogues as potential dihydroorotase inhibitors.
    Levenson CH; Meyer RB
    J Med Chem; 1984 Feb; 27(2):228-32. PubMed ID: 6141293
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mercaptan and dicarboxylate inhibitors of hamster dihydroorotase.
    Christopherson RI; Schmalzl KJ; Szabados E; Goodridge RJ; Harsanyi MC; Sant ME; Algar EM; Anderson JE; Armstrong A; Sharma SC
    Biochemistry; 1989 Jan; 28(2):463-70. PubMed ID: 2565732
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxic effects of dihydroorotase inhibitors upon human CCRF-CEM leukemia.
    Brooke J; Szabados E; Lyons SD; Goodridge RJ; Harsanyi MC; Poiner A; Christopherson RI
    Cancer Res; 1990 Dec; 50(24):7793-8. PubMed ID: 1979249
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of 6-azauridine on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells. Orotate inhibition of dihydroorotase and dihydroorotate dehydrogenase.
    Chen JJ; Jones ME
    J Biol Chem; 1979 Jun; 254(11):4908-14. PubMed ID: 35542
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).
    Peters GJ; Sharma SL; Laurensse E; Pinedo HM
    Invest New Drugs; 1987; 5(3):235-44. PubMed ID: 2822596
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum.
    Seymour KK; Lyons SD; Phillips L; Rieckmann KH; Christopherson RI
    Biochemistry; 1994 May; 33(17):5268-74. PubMed ID: 7909690
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.
    Lee M; Maher MJ; Guss JM
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2007 Mar; 63(Pt 3):154-61. PubMed ID: 17329804
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.
    Lee M; Chan CW; Graham SC; Christopherson RI; Guss JM; Maher MJ
    J Mol Biol; 2007 Jul; 370(5):812-25. PubMed ID: 17550785
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).
    Rice AJ; Lei H; Santarsiero BD; Lee H; Johnson ME
    Bioorg Med Chem; 2016 Oct; 24(19):4536-4543. PubMed ID: 27499369
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and enzymic evaluation of 4-mercapto-6-oxo-1, 4-azaphosphinane-2-carboxylic acid 4-oxide as an inhibitor of mammalian dihydroorotase.
    Manthey MK; Huang DT; Bubb WA; Christopherson RI
    J Med Chem; 1998 Nov; 41(23):4550-5. PubMed ID: 9804694
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Catalysis by hamster dihydroorotase: zinc binding, site-directed mutagenesis, and interaction with inhibitors.
    Williams NK; Manthey MK; Hambley TW; O'Donoghue SI; Keegan M; Chapman BE; Christopherson RI
    Biochemistry; 1995 Sep; 34(36):11344-52. PubMed ID: 7547862
    [TBL] [Abstract][Full Text] [Related]  

  • 13. cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1 H)-one , a potent inhibitor of mammalian dihydroorotase.
    Adams JL; Meek TD; Mong SM; Johnson RK; Metcalf BW
    J Med Chem; 1988 Jul; 31(7):1355-9. PubMed ID: 2898532
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic and structural analysis of mutant Escherichia coli dihydroorotases: a flexible loop stabilizes the transition state.
    Lee M; Maher MJ; Christopherson RI; Guss JM
    Biochemistry; 2007 Sep; 46(37):10538-50. PubMed ID: 17711307
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of Small Molecule Inhibitors against
    Rice AJ; Pesavento RP; Ren J; Youn I; Kwon Y; Ellepola K; Che CT; Johnson ME; Lee H
    Int J Mol Sci; 2021 Sep; 22(18):. PubMed ID: 34576147
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.
    Anderson MA; Cleland WW; Huang DT; Chan C; Shojaei M; Christopherson RI
    Biochemistry; 2006 Jun; 45(23):7132-9. PubMed ID: 16752903
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitors designed for the active site of dihydroorotase.
    Li Y; Raushel FM
    Bioorg Chem; 2005 Dec; 33(6):470-83. PubMed ID: 16213543
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allantoinase and dihydroorotase binding and inhibition by flavonols and the substrates of cyclic amidohydrolases.
    Peng WF; Huang CY
    Biochimie; 2014 Jun; 101():113-22. PubMed ID: 24418229
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism of the dihydroorotase reaction.
    Porter TN; Li Y; Raushel FM
    Biochemistry; 2004 Dec; 43(51):16285-92. PubMed ID: 15610022
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors.
    DeFrees SA; Sawick DP; Cunningham B; Heinstein PF; Morré DJ; Cassady JM
    Biochem Pharmacol; 1988 Oct; 37(20):3807-16. PubMed ID: 2847745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.