BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

222 related articles for article (PubMed ID: 19682598)

  • 1. Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors.
    Xu X; Yang G; Zhang H; Prestwich GD
    Prostaglandins Other Lipid Mediat; 2009 Sep; 89(3-4):140-6. PubMed ID: 19682598
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.
    Zhang H; Xu X; Gajewiak J; Tsukahara R; Fujiwara Y; Liu J; Fells JI; Perygin D; Parrill AL; Tigyi G; Prestwich GD
    Cancer Res; 2009 Jul; 69(13):5441-9. PubMed ID: 19509223
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model.
    Xu X; Prestwich GD
    Cancer; 2010 Apr; 116(7):1739-50. PubMed ID: 20143443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
    Gupte R; Patil R; Liu J; Wang Y; Lee SC; Fujiwara Y; Fells J; Bolen AL; Emmons-Thompson K; Yates CR; Siddam A; Panupinthu N; Pham TC; Baker DL; Parrill AL; Mills GB; Tigyi G; Miller DD
    ChemMedChem; 2011 May; 6(5):922-35. PubMed ID: 21465666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
    Cui P; Tomsig JL; McCalmont WF; Lee S; Becker CJ; Lynch KR; Macdonald TL
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1634-40. PubMed ID: 17257836
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Therapeutic potential of autotaxin/lysophospholipase d inhibitors.
    Federico L; Pamuklar Z; Smyth SS; Morris AJ
    Curr Drug Targets; 2008 Aug; 9(8):698-708. PubMed ID: 18691016
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells.
    Gaetano CG; Samadi N; Tomsig JL; Macdonald TL; Lynch KR; Brindley DN
    Mol Carcinog; 2009 Sep; 48(9):801-9. PubMed ID: 19204929
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX).
    East JE; Kennedy AJ; Tomsig JL; De Leon AR; Lynch KR; Macdonald TL
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7132-6. PubMed ID: 20951039
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.
    Gierse J; Thorarensen A; Beltey K; Bradshaw-Pierce E; Cortes-Burgos L; Hall T; Johnston A; Murphy M; Nemirovskiy O; Ogawa S; Pegg L; Pelc M; Prinsen M; Schnute M; Wendling J; Wene S; Weinberg R; Wittwer A; Zweifel B; Masferrer J
    J Pharmacol Exp Ther; 2010 Jul; 334(1):310-7. PubMed ID: 20392816
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.
    Saunders LP; Cao W; Chang WC; Albright RA; Braddock DT; De La Cruz EM
    J Biol Chem; 2011 Aug; 286(34):30130-41. PubMed ID: 21719699
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
    van Meeteren LA; Brinkmann V; Saulnier-Blache JS; Lynch KR; Moolenaar WH
    Cancer Lett; 2008 Aug; 266(2):203-8. PubMed ID: 18378389
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid.
    Gajewiak J; Tsukahara R; Fujiwara Y; Tigyi G; Prestwich GD
    Org Lett; 2008 Mar; 10(6):1111-4. PubMed ID: 18284246
    [TBL] [Abstract][Full Text] [Related]  

  • 13. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
    Ferry G; Moulharat N; Pradère JP; Desos P; Try A; Genton A; Giganti A; Beucher-Gaudin M; Lonchampt M; Bertrand M; Saulnier-Blache JS; Tucker GC; Cordi A; Boutin JA
    J Pharmacol Exp Ther; 2008 Dec; 327(3):809-19. PubMed ID: 18755937
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Autotaxin and lipid signaling pathways as anticancer targets.
    Braddock DT
    Curr Opin Investig Drugs; 2010 Jun; 11(6):629-37. PubMed ID: 20496257
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ATX-LPA receptor axis in inflammation and cancer.
    Liu S; Murph M; Panupinthu N; Mills GB
    Cell Cycle; 2009 Nov; 8(22):3695-701. PubMed ID: 19855166
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
    Altman MK; Gopal V; Jia W; Yu S; Hall H; Mills GB; McGinnis AC; Bartlett MG; Jiang G; Madan D; Prestwich GD; Xu Y; Davies MA; Murph MM
    Mol Cancer; 2010 Jun; 9():140. PubMed ID: 20529378
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Autotaxin inhibition: challenges and progress toward novel anti-cancer agents.
    Parrill AL; Baker DL
    Anticancer Agents Med Chem; 2008 Dec; 8(8):917-23. PubMed ID: 19075574
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.
    David M; Wannecq E; Descotes F; Jansen S; Deux B; Ribeiro J; Serre CM; Grès S; Bendriss-Vermare N; Bollen M; Saez S; Aoki J; Saulnier-Blache JS; Clézardin P; Peyruchaud O
    PLoS One; 2010 Mar; 5(3):e9741. PubMed ID: 20305819
    [TBL] [Abstract][Full Text] [Related]  

  • 19. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors.
    Cui P; McCalmont WF; Tomsig JL; Lynch KR; Macdonald TL
    Bioorg Med Chem; 2008 Mar; 16(5):2212-25. PubMed ID: 18082408
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Virtual screening approaches for the identification of non-lipid autotaxin inhibitors.
    Parrill AL; Echols U; Nguyen T; Pham TC; Hoeglund A; Baker DL
    Bioorg Med Chem; 2008 Feb; 16(4):1784-95. PubMed ID: 18036821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.