These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

116 related articles for article (PubMed ID: 19683239)

  • 1. Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells.
    Maeda A; Yano T; Itoh Y; Kakumori M; Kubota T; Egashira N; Oishi R
    Atherosclerosis; 2010 Jan; 208(1):112-8. PubMed ID: 19683239
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.
    Blanco-Colio LM; Villa A; Ortego M; Hernández-Presa MA; Pascual A; Plaza JJ; Egido J
    Atherosclerosis; 2002 Mar; 161(1):17-26. PubMed ID: 11882313
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis.
    Nagashima T; Okazaki H; Yudoh K; Matsuno H; Minota S
    Arthritis Rheum; 2006 Feb; 54(2):579-86. PubMed ID: 16447234
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.
    Kubota T; Fujisaki K; Itoh Y; Yano T; Sendo T; Oishi R
    Biochem Pharmacol; 2004 Jun; 67(12):2175-86. PubMed ID: 15163549
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
    Lee MH; Cho YS; Han YM
    Stem Cells; 2007 Jul; 25(7):1654-63. PubMed ID: 17464088
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Statins suppress glucose-induced plasminogen activator inhibitor-1 expression by regulating RhoA and nuclear factor-κB activities in cardiac microvascular endothelial cells.
    Ni XQ; Zhu JH; Yao NH; Qian J; Yang XJ
    Exp Biol Med (Maywood); 2013 Jan; 238(1):37-46. PubMed ID: 23479762
    [TBL] [Abstract][Full Text] [Related]  

  • 7. HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.
    Narumiya H; Sasaki S; Kuwahara N; Irie H; Kusaba T; Kameyama H; Tamagaki K; Hatta T; Takeda K; Matsubara H
    Cardiovasc Res; 2004 Nov; 64(2):331-6. PubMed ID: 15485693
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells.
    Cafforio P; Dammacco F; Gernone A; Silvestris F
    Carcinogenesis; 2005 May; 26(5):883-91. PubMed ID: 15705602
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.
    Kusama T; Mukai M; Iwasaki T; Tatsuta M; Matsumoto Y; Akedo H; Nakamura H
    Cancer Res; 2001 Jun; 61(12):4885-91. PubMed ID: 11406567
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.
    Danesh FR; Sadeghi MM; Amro N; Philips C; Zeng L; Lin S; Sahai A; Kanwar YS
    Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8301-5. PubMed ID: 12048257
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.
    Itagaki M; Takaguri A; Kano S; Kaneta S; Ichihara K; Satoh K
    J Pharmacol Sci; 2009 Jan; 109(1):94-101. PubMed ID: 19129682
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression.
    Li R; Gan YH
    Int J Mol Sci; 2017 May; 18(5):. PubMed ID: 28481295
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation.
    Al-Haidari AA; Syk I; Thorlacius H
    Biochem Biophys Res Commun; 2014 Mar; 446(1):68-72. PubMed ID: 24582560
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism.
    Yoshida M; Sawada T; Ishii H; Gerszten RE; Rosenzweig A; Gimbrone MA; Yasukochi Y; Numano F
    Arterioscler Thromb Vasc Biol; 2001 Jul; 21(7):1165-71. PubMed ID: 11451746
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition.
    Serra N; Rosales R; Masana L; Vallvé JC
    PLoS One; 2015; 10(7):e0133875. PubMed ID: 26207907
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways.
    Chen JC; Huang KC; Lin WW
    Cell Signal; 2006 Jan; 18(1):32-9. PubMed ID: 16214041
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The role of geranylgeranylated proteins in human mesangial cell proliferation.
    Khwaja A; Sharpe CC; Noor M; Hendry BM
    Kidney Int; 2006 Oct; 70(7):1296-304. PubMed ID: 16929252
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.
    Kusama T; Mukai M; Ayaki M; Imamura F; Tatsuta M; Matsumoto Y; Nakamura H; Inoue M
    Int J Oncol; 2003 Oct; 23(4):1173-8. PubMed ID: 12964001
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling.
    Zhong WB; Liang YC; Wang CY; Chang TC; Lee WS
    Endocr Relat Cancer; 2005 Sep; 12(3):615-29. PubMed ID: 16172195
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study.
    Denoyelle C; Vasse M; Körner M; Mishal Z; Ganné F; Vannier JP; Soria J; Soria C
    Carcinogenesis; 2001 Aug; 22(8):1139-48. PubMed ID: 11470741
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.