These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 19686718)

  • 1. Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
    Guerrero MD; Aquino M; Bruno I; Riccio R; Terencio MC; Payá M
    Eur J Pharmacol; 2009 Oct; 620(1-3):112-9. PubMed ID: 19686718
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages.
    Xiao L; Ornatowska M; Zhao G; Cao H; Yu R; Deng J; Li Y; Zhao Q; Sadikot RT; Christman JW
    PLoS One; 2012; 7(11):e50244. PubMed ID: 23226252
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.
    Guerrero MD; Aquino M; Bruno I; Terencio MC; Paya M; Riccio R; Gomez-Paloma L
    J Med Chem; 2007 May; 50(9):2176-84. PubMed ID: 17407277
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Toward the discovery of new agents able to inhibit the expression of microsomal prostaglandin E synthase-1 enzyme as promising tools in drug development.
    De Simone R; Andrés RM; Aquino M; Bruno I; Guerrero MD; Terencio MC; Paya M; Riccio R
    Chem Biol Drug Des; 2010 Jul; 76(1):17-24. PubMed ID: 20492447
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
    Schaible AM; Traber H; Temml V; Noha SM; Filosa R; Peduto A; Weinigel C; Barz D; Schuster D; Werz O
    Biochem Pharmacol; 2013 Aug; 86(4):476-86. PubMed ID: 23623753
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
    Chan CC; Boyce S; Brideau C; Charleson S; Cromlish W; Ethier D; Evans J; Ford-Hutchinson AW; Forrest MJ; Gauthier JY; Gordon R; Gresser M; Guay J; Kargman S; Kennedy B; Leblanc Y; Leger S; Mancini J; O'Neill GP; Ouellet M; Patrick D; Percival MD; Perrier H; Prasit P; Rodger I
    J Pharmacol Exp Ther; 1999 Aug; 290(2):551-60. PubMed ID: 10411562
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.
    Li X; Afif H; Cheng S; Martel-Pelletier J; Pelletier JP; Ranger P; Fahmi H
    J Rheumatol; 2005 May; 32(5):887-95. PubMed ID: 15868626
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.
    Koeberle A; Werz O
    Biochem Pharmacol; 2015 Nov; 98(1):1-15. PubMed ID: 26123522
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils.
    Mosca M; Polentarutti N; Mangano G; Apicella C; Doni A; Mancini F; De Bortoli M; Coletta I; Polenzani L; Santoni G; Sironi M; Vecchi A; Mantovani A
    J Leukoc Biol; 2007 Aug; 82(2):320-6. PubMed ID: 17505022
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
    Mbalaviele G; Pauley AM; Shaffer AF; Zweifel BS; Mathialagan S; Mnich SJ; Nemirovskiy OV; Carter J; Gierse JK; Wang JL; Vazquez ML; Moore WM; Masferrer JL
    Biochem Pharmacol; 2010 May; 79(10):1445-54. PubMed ID: 20067770
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
    Koeberle A; Rossi A; Zettl H; Pergola C; Dehm F; Bauer J; Greiner C; Reckel S; Hoernig C; Northoff H; Bernhard F; Dötsch V; Sautebin L; Schubert-Zsilavecz M; Werz O
    J Pharmacol Exp Ther; 2010 Mar; 332(3):840-8. PubMed ID: 19934399
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
    Bruno A; Di Francesco L; Coletta I; Mangano G; Alisi MA; Polenzani L; Milanese C; Anzellotti P; Ricciotti E; Dovizio M; Di Francesco A; Tacconelli S; Capone ML; Patrignani P
    Biochem Pharmacol; 2010 Apr; 79(7):974-81. PubMed ID: 19925781
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.
    Kojima F; Naraba H; Miyamoto S; Beppu M; Aoki H; Kawai S
    Arthritis Res Ther; 2004; 6(4):R355-65. PubMed ID: 15225371
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Membrane prostaglandin E synthase-1: a novel therapeutic target.
    Samuelsson B; Morgenstern R; Jakobsson PJ
    Pharmacol Rev; 2007 Sep; 59(3):207-24. PubMed ID: 17878511
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.
    Frolov A; Yang L; Dong H; Hammock BD; Crofford LJ
    Prostaglandins Leukot Essent Fatty Acids; 2013 Oct; 89(5):351-8. PubMed ID: 24055573
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts.
    Kojima F; Naraba H; Sasaki Y; Beppu M; Aoki H; Kawai S
    Arthritis Rheum; 2003 Oct; 48(10):2819-28. PubMed ID: 14558087
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages.
    Ninomiya Y; Yasuda T; Kawamoto M; Yuge O; Okazaki Y
    J Steroid Biochem Mol Biol; 2007 Jan; 103(1):44-50. PubMed ID: 17049841
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
    Xu D; Rowland SE; Clark P; Giroux A; Côté B; Guiral S; Salem M; Ducharme Y; Friesen RW; Méthot N; Mancini J; Audoly L; Riendeau D
    J Pharmacol Exp Ther; 2008 Sep; 326(3):754-63. PubMed ID: 18524979
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
    Koeberle A; Haberl EM; Rossi A; Pergola C; Dehm F; Northoff H; Troschuetz R; Sautebin L; Werz O
    Bioorg Med Chem; 2009 Dec; 17(23):7924-32. PubMed ID: 19884011
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Prostaglandin E synthase in the pathophysiology of arthritis.
    Kojima F; Kato S; Kawai S
    Fundam Clin Pharmacol; 2005 Jun; 19(3):255-61. PubMed ID: 15910650
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.