107 related articles for article (PubMed ID: 19687151)
1. Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.
Thörn HA; Hedeland M; Bondesson U; Knutson L; Yasin M; Dickinson P; Lennernäs H
Drug Metab Dispos; 2009 Nov; 37(11):2186-96. PubMed ID: 19687151
[TBL] [Abstract][Full Text] [Related]
2. Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo.
Thörn HA; Sjögren E; Dickinson PA; Lennernäs H
Mol Pharm; 2012 Nov; 9(11):3034-45. PubMed ID: 23009633
[TBL] [Abstract][Full Text] [Related]
3. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism.
Tannergren C; Engman H; Knutson L; Hedeland M; Bondesson U; Lennernäs H
Clin Pharmacol Ther; 2004 Apr; 75(4):298-309. PubMed ID: 15060508
[TBL] [Abstract][Full Text] [Related]
4. Stereoselective first-pass metabolism of verapamil in the small intestine and liver in rats.
Hanada K; Ikemi Y; Kukita K; Mihara K; Ogata H
Drug Metab Dispos; 2008 Oct; 36(10):2037-42. PubMed ID: 18617604
[TBL] [Abstract][Full Text] [Related]
5. Input rate-dependent stereoselective pharmacokinetics. Experimental evidence in verapamil-infused isolated rat livers.
Mehvar R; Reynolds J
Drug Metab Dispos; 1995 Jun; 23(6):637-41. PubMed ID: 7587945
[TBL] [Abstract][Full Text] [Related]
6. In vivo investigation in pigs of intestinal absorption, hepatobiliary disposition, and metabolism of the 5α-reductase inhibitor finasteride and the effects of coadministered ketoconazole.
Lundahl A; Hedeland M; Bondesson U; Lennernäs H
Drug Metab Dispos; 2011 May; 39(5):847-57. PubMed ID: 21317368
[TBL] [Abstract][Full Text] [Related]
7. Simultaneous analysis of the enantiomers of verapamil and norverapamil in rat plasma by liquid chromatography-tandem mass spectrometry.
Mateus FH; Lepera JS; Marques MP; Boralli VB; Lanchote VL
J Pharm Biomed Anal; 2007 Dec; 45(5):762-8. PubMed ID: 17981422
[TBL] [Abstract][Full Text] [Related]
8. The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans.
Sandström R; Knutson TW; Knutson L; Jansson B; Lennernäs H
Br J Clin Pharmacol; 1999 Aug; 48(2):180-9. PubMed ID: 10417494
[TBL] [Abstract][Full Text] [Related]
9. Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4.
Ha PT; Sluyts I; Van Dyck S; Zhang J; Gilissen RA; Hoogmartens J; VanSchepdael A
J Chromatogr A; 2006 Jul; 1120(1-2):94-101. PubMed ID: 16376901
[TBL] [Abstract][Full Text] [Related]
10. Reversal of stereoselectivity in the hepatic availability of verapamil in isolated perfused rat livers. Role of protein binding.
Mehvar R; Reynolds J
Drug Metab Dispos; 1996 Oct; 24(10):1088-94. PubMed ID: 8894509
[TBL] [Abstract][Full Text] [Related]
11. Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys.
Ogasawara A; Kume T; Kazama E
Drug Metab Dispos; 2007 Mar; 35(3):410-8. PubMed ID: 17142564
[TBL] [Abstract][Full Text] [Related]
12. Differentiation of gut and hepatic first-pass loss of verapamil in intestinal and vascular access-ported (IVAP) rabbits.
Kunta JR; Lee SH; Perry BA; Lee YH; Sinko PJ
Drug Metab Dispos; 2004 Nov; 32(11):1293-8. PubMed ID: 15304428
[TBL] [Abstract][Full Text] [Related]
13. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Kharasch ED; Walker A; Hoffer C; Sheffels P
Clin Pharmacol Ther; 2004 Nov; 76(5):452-66. PubMed ID: 15536460
[TBL] [Abstract][Full Text] [Related]
14. Influence of N-hexane inhalation on the enantioselective pharmacokinetics and metabolism of verapamil in rats.
Mateus FH; Lepera JS; Marques MP; Boralli VB; Lanchote VL
Chirality; 2010 Jan; 22(1):29-34. PubMed ID: 19229957
[TBL] [Abstract][Full Text] [Related]
15. First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.
Petri N; Bergman E; Forsell P; Hedeland M; Bondesson U; Knutson L; Lennernäs H
Drug Metab Dispos; 2006 Jul; 34(7):1182-9. PubMed ID: 16621934
[TBL] [Abstract][Full Text] [Related]
16. Pharmacokinetic interaction between verapamil and metoprolol in the dog. Stereochemical aspects.
Murthy SS; Nelson WL; Shen DD; Power JM; Cahill CM; McLean AJ
Drug Metab Dispos; 1991; 19(6):1093-100. PubMed ID: 1687016
[TBL] [Abstract][Full Text] [Related]
17. Repeated oral rifampicin decreases the jejunal permeability of R/S-verapamil in rats.
Sandström R; Lennernäs H
Drug Metab Dispos; 1999 Aug; 27(8):951-5. PubMed ID: 10421625
[TBL] [Abstract][Full Text] [Related]
18. Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.
Ward KW; Stelman GJ; Morgan JA; Zeigler KS; Azzarano LM; Kehler JR; McSurdy-Freed JE; Proksch JW; Smith BR
Drug Metab Dispos; 2004 Feb; 32(2):172-7. PubMed ID: 14744938
[TBL] [Abstract][Full Text] [Related]
19. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human.
Wang J; Xia S; Xue W; Wang D; Sai Y; Liu L; Liu X
Eur J Pharm Sci; 2013 Nov; 50(3-4):290-302. PubMed ID: 23916407
[TBL] [Abstract][Full Text] [Related]
20. PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.
Yang QJ; Si L; Tang H; Sveigaard HH; Chow EC; Pang KS
Drug Metab Dispos; 2015 Apr; 43(4):631-45. PubMed ID: 25650380
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
