443 related articles for article (PubMed ID: 19694467)
21. 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Jelley RA; Elliott J; Gibson KR; Harrison T; Beher D; Clarke EE; Lewis HD; Shearman M; Wrigley JD
Bioorg Med Chem Lett; 2006 Jul; 16(14):3839-42. PubMed ID: 16682202
[TBL] [Abstract][Full Text] [Related]
22. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
Zhu Y; Xiao K; Ma L; Xiong B; Fu Y; Yu H; Wang W; Wang X; Hu D; Peng H; Li J; Gong Q; Chai Q; Tang X; Zhang H; Li J; Shen J
Bioorg Med Chem; 2009 Feb; 17(4):1600-13. PubMed ID: 19162488
[TBL] [Abstract][Full Text] [Related]
23. [Secretases as therapeutic targets for the treatment of Alzheimer's disease].
Dejaegere T; de Strooper B
Verh K Acad Geneeskd Belg; 2004; 66(1):29-58; discussion 58-9. PubMed ID: 15074081
[TBL] [Abstract][Full Text] [Related]
24. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
25. Pore-forming scissors? A first structural glimpse of gamma-secretase.
Steiner H; Than M; Bode W; Haass C
Trends Biochem Sci; 2006 Sep; 31(9):491-3. PubMed ID: 16890442
[TBL] [Abstract][Full Text] [Related]
26. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
[TBL] [Abstract][Full Text] [Related]
27. Advances in gamma-secretase modulation.
Pissarnitski D
Curr Opin Drug Discov Devel; 2007 Jul; 10(4):392-402. PubMed ID: 17659480
[TBL] [Abstract][Full Text] [Related]
28. Progress toward the discovery and development of efficacious BACE inhibitors.
Durham TB; Shepherd TA
Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
[TBL] [Abstract][Full Text] [Related]
29. Alzheimer's disease sends the wrong signals--a perspective.
Neve RL
Amyloid; 2008 Mar; 15(1):1-4. PubMed ID: 18266116
[TBL] [Abstract][Full Text] [Related]
30. 2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
Pissarnitski DA; Asberom T; Bara TA; Buevich AV; Clader JW; Greenlee WJ; Guzik HS; Josien HB; Li W; McEwan M; McKittrick BA; Nechuta TL; Parker EM; Sinning L; Smith EM; Song L; Vaccaro HA; Voigt JH; Zhang L; Zhang Q; Zhao Z
Bioorg Med Chem Lett; 2007 Jan; 17(1):57-62. PubMed ID: 17055268
[TBL] [Abstract][Full Text] [Related]
31. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Cole DC; Stock JR; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jennings LD; Jin G; Lohse PA; Malamas MS; Manas ES; Moore WJ; O'Donnell MM; Olland AM; Robichaud AJ; Svenson K; Wu J; Wagner E; Bard J
Bioorg Med Chem Lett; 2008 Feb; 18(3):1063-6. PubMed ID: 18162398
[TBL] [Abstract][Full Text] [Related]
32. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo.
Elvang AB; Volbracht C; Pedersen LØ; Jensen KG; Karlsson JJ; Larsen SA; Mørk A; Stensbøl TB; Bastlund JF
J Neurochem; 2009 Sep; 110(5):1377-87. PubMed ID: 19519664
[TBL] [Abstract][Full Text] [Related]
33. Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase.
Middendorp O; Lüthi U; Hausch F; Barberis A
Biol Chem; 2004 Jun; 385(6):481-5. PubMed ID: 15255179
[TBL] [Abstract][Full Text] [Related]
34. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
[TBL] [Abstract][Full Text] [Related]
35. [Therapy of Alzheimer disease].
Kovács T
Neuropsychopharmacol Hung; 2009 Mar; 11(1):27-33. PubMed ID: 19731816
[TBL] [Abstract][Full Text] [Related]
36. Simple structure-based approach for predicting the activity of inhibitors of beta-secretase (BACE1) associated with Alzheimer's disease.
Nastase AF; Boyd DB
J Chem Inf Model; 2012 Dec; 52(12):3302-7. PubMed ID: 23198745
[TBL] [Abstract][Full Text] [Related]
37. Design of potent inhibitors of human beta-secretase. Part 2.
Freskos JN; Fobian YM; Benson TE; Moon JB; Bienkowski MJ; Brown DL; Emmons TL; Heintz R; Laborde A; McDonald JJ; Mischke BV; Molyneaux JM; Mullins PB; Bryan Prince D; Paddock DJ; Tomasselli AG; Winterrowd G
Bioorg Med Chem Lett; 2007 Jan; 17(1):78-81. PubMed ID: 17049233
[TBL] [Abstract][Full Text] [Related]
38. NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.
Baumann S; Höttecke N; Schubenel R; Baumann K; Schmidt B
Bioorg Med Chem Lett; 2009 Dec; 19(24):6986-90. PubMed ID: 19879754
[TBL] [Abstract][Full Text] [Related]
39. γ-Secretase inhibitors and modulators for Alzheimer's disease.
Wolfe MS
J Neurochem; 2012 Jan; 120 Suppl 1(Suppl 1):89-98. PubMed ID: 22122056
[TBL] [Abstract][Full Text] [Related]
40. Biomedicine. Avoiding collateral damage in Alzheimer's disease treatment.
Glabe C
Science; 2006 Oct; 314(5799):602-3. PubMed ID: 17068248
[No Abstract] [Full Text] [Related]
[Previous] [Next] [New Search]