237 related articles for article (PubMed ID: 19697956)
1. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Deweese JE; Guengerich FP; Burgin AB; Osheroff N
Biochemistry; 2009 Sep; 48(38):8940-7. PubMed ID: 19697956
[TBL] [Abstract][Full Text] [Related]
2. Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.
Deweese JE; Burch AM; Burgin AB; Osheroff N
Biochemistry; 2009 Mar; 48(9):1862-9. PubMed ID: 19222228
[TBL] [Abstract][Full Text] [Related]
3. Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.
Deweese JE; Burgin AB; Osheroff N
Nucleic Acids Res; 2008 Sep; 36(15):4883-93. PubMed ID: 18653531
[TBL] [Abstract][Full Text] [Related]
4. Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.
Dickey JS; Osheroff N
Biochemistry; 2005 Aug; 44(34):11546-54. PubMed ID: 16114891
[TBL] [Abstract][Full Text] [Related]
5. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Bender RP; Osheroff N
Chem Res Toxicol; 2007 Jun; 20(6):975-81. PubMed ID: 17516663
[TBL] [Abstract][Full Text] [Related]
6. Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ; Schwanz HA; Li G; McPherson SA; Turnbough CL; Kerns RJ; Osheroff N
ACS Chem Biol; 2013 Dec; 8(12):2660-8. PubMed ID: 24047414
[TBL] [Abstract][Full Text] [Related]
7. Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage.
Bromberg KD; Burgin AB; Osheroff N
Biochemistry; 2003 Apr; 42(12):3393-8. PubMed ID: 12653542
[TBL] [Abstract][Full Text] [Related]
8. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.
Lindsey RH; Pendleton M; Ashley RE; Mercer SL; Deweese JE; Osheroff N
Biochemistry; 2014 Oct; 53(41):6595-602. PubMed ID: 25280269
[TBL] [Abstract][Full Text] [Related]
9. Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.
Deweese JE; Burgin AB; Osheroff N
Biochemistry; 2008 Apr; 47(13):4129-40. PubMed ID: 18318502
[TBL] [Abstract][Full Text] [Related]
10. Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain.
McClendon AK; Gentry AC; Dickey JS; Brinch M; Bendsen S; Andersen AH; Osheroff N
Biochemistry; 2008 Dec; 47(50):13169-78. PubMed ID: 19053267
[TBL] [Abstract][Full Text] [Related]
11. The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA.
Gilroy KL; Austin CA
PLoS One; 2011 Feb; 6(2):e14693. PubMed ID: 21358820
[TBL] [Abstract][Full Text] [Related]
12. Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIalpha by selective mutagenesis.
Hammonds TR; Foster SR; Maxwell A
J Mol Biol; 2000 Jul; 300(3):481-91. PubMed ID: 10884345
[TBL] [Abstract][Full Text] [Related]
13. Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.
Deweese JE; Osheroff N
Biochemistry; 2009 Feb; 48(7):1439-41. PubMed ID: 19166355
[TBL] [Abstract][Full Text] [Related]
14. Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.
McClendon AK; Rodriguez AC; Osheroff N
J Biol Chem; 2005 Nov; 280(47):39337-45. PubMed ID: 16188892
[TBL] [Abstract][Full Text] [Related]
15. Assignment of functional amino acids around the active site of human DNA topoisomerase IIalpha.
Okada Y; Ito Y; Kikuchi A; Nimura Y; Yoshida S; Suzuki M
J Biol Chem; 2000 Aug; 275(32):24630-8. PubMed ID: 10807924
[TBL] [Abstract][Full Text] [Related]
16. DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.
Lee S; Jung SR; Heo K; Byl JA; Deweese JE; Osheroff N; Hohng S
Proc Natl Acad Sci U S A; 2012 Feb; 109(8):2925-30. PubMed ID: 22323612
[TBL] [Abstract][Full Text] [Related]
17. Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.
Kozuki T; Chikamori K; Surleac MD; Micluta MA; Petrescu AJ; Norris EJ; Elson P; Hoeltge GA; Grabowski DR; Porter ACG; Ganapathi RN; Ganapathi MK
Nucleic Acids Res; 2017 Jun; 45(10):5995-6010. PubMed ID: 28472494
[TBL] [Abstract][Full Text] [Related]
18. Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage.
West KL; Meczes EL; Thorn R; Turnbull RM; Marshall R; Austin CA
Biochemistry; 2000 Feb; 39(6):1223-33. PubMed ID: 10684600
[TBL] [Abstract][Full Text] [Related]
19. Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.
Seol Y; Gentry AC; Osheroff N; Neuman KC
J Biol Chem; 2013 May; 288(19):13695-703. PubMed ID: 23508957
[TBL] [Abstract][Full Text] [Related]
20. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.
Bender RP; Ham AJ; Osheroff N
Biochemistry; 2007 Mar; 46(10):2856-64. PubMed ID: 17298034
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]